CURING AGING

Burz Ana, Cherecheș Milena, Condrat Alice, Lăpușan Bianca, Suciu Titus
Cls a X-a A
 Our focus

✤ Health is one of the most important elements of life

✤ The human race has reached the maximum lifespan in history

✤ Unexpected turn: we spend a large amount of time in pain due to

ageing

✤ lifesnap.io is an association of scientists that is interested in optimising

healthspan
Mitochondrial DNA engineering
✤ Mitochondria: cellular organelle that is
responsible of producing energy used by the cell
to perform all their functions ✤ the main dysfunctions
associated with
✤ In this process, the organelle accidentally
produces toxic molecules called reactive oxygen mitochondrial mutations
species that interact with DNA causing changes are Parkinson and
in gene composition
muscular diseases
✤ The final result is an abnormal cell that affects ✤ Scientists are looking for
the whole system
methods of creating gene
backups located in the
nucleus(where they are
much safer)
Senescent cells
✤ Cells undergo mitosis, process which
affects chromosomal ends called telomers
✤ Concomitant with telomere deterioration,
apoptosis occurs (programmed cell death)
✤ Senescent cells do not follow the normal
pathway, transforming themselves into
abnormal ones
✤ A great number of senescent cells is associated with
age and a number of health issues, such as diabetes
and kidney failure

✤ A way of combating this problem is by injecting a

protein that is not present in “zombie”cells, thus not
affecting normal ones
NAD+
✤ NAD+ is a coenzyme responsible of general cell well being , as well as DNA reparation

✤ With age, NAD+ intracellular concentration decreases, as we have half of it at the age of
50 in comparison with 20

✤ This coenzyme deficiency causes skin cancer, Alzheimer’s, cardiovascular and multiple
sclerosis

✤ Its conformation enables it to pass the membrane, so it cannot be ingested as a pill

✤ Scientist discovered a chemical compound able to enter the cell, and transform itself into
NAD+

✤ NASA developed interest in this research, as it benefits astronauts with its ability to
repair DNA damaged by cosmic radiation

✤ In conclusion, NAD+ represents a strong candidate, as it may be the first anti-aging pill
 Stem cells
✤ Stem cells are totipotent,
meaning that they ensure a flow
of young cells with the ability to
differentiate into any type
✤ Their number declines with age,
causing a number of dysfunctions

✤ Scientists have taken stem cells from embryos

and injected them in adult mice brains (in the
hypothalamus=regulates a number of bodily
functions)

✤ they discovered that the cells reinvigorated

neurons by secreting micro RNAs, a chemical
compound that regulates metabolism
Conclusion

✤ In conclusion there isn’t only one miracle cure of

aging

✤ We need a number of different therapies in order

to fix this

✤ Major methods: mitochondrial DNA engineering,

killing senescent cells, DNA reparation with
NAD+ and regulating metabolism with stem cells

✤ If you want to become part of a community that

actively supports such an important research, you
can fund these ideas on lifespan.io

✤ Grow old and healthy with us!