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C O C O C O C O C O
(H C OH)n H C OH H C OH H C OH H C OH
CH2OH CH2OH H C OH H C OH H C OH
D and L Enantiomers.
Epimers.
Optical activity
1- D & L isomers (enantiomers)
Ribose Deoxyribose
Monosaccharides
Physiological Importance
• Hexoses of Physiologic importance:
Glucose .
Fructose
Galactose .
D-glucose
Common names: •
glucose, grape sugar, dextrose •
Natural Source: •
Fruits,,cereal starch hydrolysis, sugar •
hydrolysis, corn syrup and honey. •
Importance: •
the sugar of the body, the principal one used by the •
tissue.
Building block for: disaccharides (such as sucrose, •
lactose and maltose) and polysaccharides (starch,
cellulose and glycogen) converted to ribose and
deoxyribose for DNA and RNA synthesis.
D-galactose
Natural Source: •
None for free form •
Formed by hydrolysis of lactose (milk sugar). •
Importance: converted to glucose, and used for •
the synthesis of Milk.
enter in cellular membranes of brain & •
nervous system.
Deficiency diseases: •
Galactosemia: •
Enzyme to metabolize galactose missing and •
levels build in blood cause mental retardation,
cataracts and cirrhosis.
D-fructose
Common names: •
Levulose and fruit sugar •
Natural Source: •
Fruit juice and honey •
Hydrolysis of cane and beat sugar •
Importance: converted to glucose in liver, •
source of energy for spermatozoa
Due to sweetness, used as sweetener. •
Monosaccharides derivative
1-Amino sugar (replacement of one hydroxyl group •
by amino group e.g, glucose amine (in glycoprotein
and glycolipid and glycosaminoglycan a
heteropolysaccharide erythromicine(antibiotic)
2- Phosphate ester in metabolism. •
. •
Disaccharides
Maltose
Disaccharides
Sucrose
Sucrose: table sugar, found in cane and beat •
sugar
composed of glucose and fructose through •
an α-(1,2)b-glycosidic bond.
give Glucose + fructose by sucrase •
enzyme(invertase) because the product of its
hydrolysis (known as invert sugar) invert
optical activity from dextro to levorotatory.
Disaccharides
Sucrose
Disaccharides
Lactose
Lactose: Milk sugar , is found exclusively in
the milk of mammals and consists of
galactose and glucose in a β-(1,4) glycosidic
bond
give Glucose + galactose by lactase enzyme •
Disaccharides
Lactose
Lactose Intolerance
Symptoms •
Bloating, abdominal discomfort, and •
diarrhea
Causes •
Lactase deficiency •
Oligosacchrides •
Usually not found free but in the form of •
glycoprotein and glycolipid.few e,g
maltotriose and raffinose.
Sucrose: prevalent in Lactose: is found
sugar cane and exclusively in the
sugar beets, is milk of mammals and
composed of
consists of galactose
glucose and fructose
through an α-(1,2)b- and glucose in a β-
glycosidic bond. (1,4) glycosidic bond
Maltose: the major degradation
product of starch, is composed
of 2 glucose monomers in an α-
(1,4) glycosidic bond.
Classification of polysaccharide •