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• 10-15% predisposition
• BRCA1,BRCA2 and Lynch syndrome have an increased
life time risk of epithelial ovarian cancer
• Most common hereditary cancer is breast ovarian
cancer syndrome (BRCA) – 90%
– Mutation ins BRCA1 (80% ) and BRCA2 in 15 %
• Lynch syndrome is hereditary non polyposis colorectal
cancer
– Associated with endometrial cancer
• There are adenocarcinomas
• Present in later stages with exception of Lynch
syndrome
Preventing ovarian cancer
Screening
• TVUSS and CA125 measurement shows no
improvement in survival in women with
familial predisposition
– BRCA mutation carrier status develop rapidly and
present in later stage before dxed by screen