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Violation during
alcohol smoking Drug abuse
pregnancy
Caused
Preterm Labor
Preterm and Psychobiological
Over-activation Fluctuation Stimulation
Maternal stress, • Sympathis nervous • Sympathetic system hypothalamic-
depression, anxiety • Vascular contraction • Imunne system pituitary-adrenal
• Neurpendocrine system • Cardiovascular system axis(HPA)
Released
Stimulate fetal
Increased levels of • Cortisol Increased allostatic
hormonal activity
placental CRH • Corticotrophim-releasing load
prematurely hormone
Sterr reactivity
Mother Chronic
•Race/athn city stress
Stress realited
pregnancy
Health risk behaviors medical
condiions
Allostatic load
measure
Stressors
Chronic stressors
Production of
Increase of CAPs Preterm Labor
estrogens
Consequence
long-term
Prenatal death neurological Exorbitant costs
disorders
Respiratory,
Immune
gastrointestinal Cerebral palsy
problems
and renal problem
Mental
retardation
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