SINTEZA INSULINEI

HOMEOSTAZIA GLUCOZEI
Diabetul zaharat - diagnostic

 Semnele clasice (poliurie, polidipsie,polifagie,

scadere in greutate) si o glicemie ≥ 200mg/dl
(in orice moment al zilei)
 Glicemie a jeun ≥ 126mg/dl, repetata de cel
putin 2 ori, sugereaza, de asemenea, diabetul
zaharat
 TTGO – glicemia la 2h≥200mg/dl

 HbA1c ≥ 6.7% - e sugestiva pt DZ

Caracteristicile DZ
Caracteristici Diabet zaharat tip1 Diabet zaharat tip 2

Varsta Copii, adolescenti Adulti, varstnici

Debutul Acut (cel mai frecvent) silentios

Scaderea in greutate frecventa inconstanta

cetoacidoza frecventa inconstanta

Insulinemia Scazuta sau abenta Normala sau crescuta

Istoric familial de DZ rar frecvent

Asociere HLA DR3, DR4 -

 Markeri de urmarire a DZ

 Glicemia, TTGO
 Lipide si lipoproteine (CT, TG, HDL-C, LDL-C,
apoA, apoB)
 HbA1

 Albuminuria

 Corpi cetonici

 Autoanticorpi