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PREPARED BY:
ASHOK THAKKAR
Mail id: ashokmba2000@yahoo.co.in
Population
REJECT
Null Hypothesis
X 20
ASHOK THAKKAR© 2002 Prentice-Hall, Inc. Chap 9-11
Reason for Rejecting H0
Sampling Distribution of X
It is unlikely that ... Therefore,
we would get a we reject the
sample mean of null hypothesis
this value ... that m = 50.
20 = 50 X
If H0 is true
ASHOK THAKKAR© 2002 Prentice-Hall, Inc. Chap 9-12
Components of Biostatistics
Biostatistics
Statistical
Descriptive
Inference
Rejection 0
Regions
H0: 3
H1: > 3
0
/2
H0: 3
H1: 3
0
Assumptions
Population is normally distributed
If not normal, requires large samples
Null hypothesis has or sign only
Z test statistic
X X X
Z
X / n
0 Z 0 Z
Z Must Be Significantly Small values of Z don’t
Below 0 to reject H0 contradict H0
Don’t Reject H0 !
ASHOK THAKKAR© 2002 Prentice-Hall, Inc. Chap 9-35
Example: One Tail Test
Q. Does an average box of
cereal contain more than
368 grams of cereal? A
random sample of 25
boxes showed X = 372.5.
The company has 368 gm.
specified to be 15 grams.
Test at the 0.05 level. H0: 368
H1: > 368
Reject
= 0.05
0 1.645
Z
1.50
Test Statistic 1.50 is in the Do Not Reject Region
ASHOK THAKKAR© 2002 Prentice-Hall, Inc. Chap 9-40
Example: Two-Tail Test
Q. Does an average box
of cereal contain 368
grams of cereal? A
random sample of 25
boxes showed X =
372.5. The company 368 gm.
has specified to be
15 grams. Test at the H0: 368
0.05 level.
H1: 368
Reject Reject
= 0.05
0 1.50 1.96
Z
Test Statistic 1.50 is in the Do Not Reject Region
ASHOK THAKKAR© 2002 Prentice-Hall, Inc. Chap 9-43
Connection to
Confidence Intervals
For X 372.5, 15 and n 25,
the 95% confidence interval is:
372.5 1.96 15 / 25 372.5 1.96 15 / 25
or
366.62 378.38
If this interval contains the hypothesized mean (368),
we do not reject the null hypothesis.
It does. Do not reject.
ASHOK THAKKAR© 2002 Prentice-Hall, Inc. Chap 9-44
What is a t Test?
Commonly Used
Definition: Comparing
two means to see if
they are significantly
different from each
other
Technical Definition:
Any statistical test that
uses the t family of
distributions
One sample
compare with population
Unpaired
compare with control
Paired
same subjects: pre-post
Z-test
large samples >30
ASHOK THAKKAR© 2002 Prentice-Hall, Inc. Chap 9-49
Compare Means (or medians)Example:
Compare blood presures of two or more groups, or
compare BP of one group with a theoretical value.
1 Group:
1. One Sample t test
2. Wilcoxon rank sum test
2 Groups:
1. Unpaired t test
2. Paired t test
3. Mann-Whitney t test
4. Welch’s corrected t test
5. Wilcoxon matched pairs test
ASHOK THAKKAR© 2002 Prentice-Hall, Inc. Chap 9-50
3-26 Groups:
1. One-way ANOVA
2. Repeated measures ANOVA
3. Kruskal-Wallis test
4. Friedman test
(All with post tests) Raw data Average data
Mean, SD, & NAverage data Mean, SEM, & N
between you…means,
who is meaner?
ASHOK THAKKAR© 2002 Prentice-Hall, Inc. Chap 9-52
Statistical Analysis
control treatment
group group
mean mean
Is there a difference?
ASHOK THAKKAR© 2002 Prentice-Hall, Inc. Chap 9-53
Slide downloaded from the Internet
What does difference mean?
The mean difference
medium is the same for all
variability three cases
high
variability
low
variability
medium
variability
high
variability