potensi obat ANTIDEPRESAN

yang bersumber dari ALGA

(revisi)

Galih Widi Sudiro

Pembimbing : Prof.Dr.Sumi Hudiyono PWS

LATAR BELAKANG
DEPRESI
-350.000.000 penderita
-penyebab disabilitas no.2
-“tren” penyakit masa depan
Neurotransmitter monoamine

GABA Nor-
Serotonin Dopamin
adrenalin
 Reseptor
Produksi

Re-uptake
 Kerja obat antidepresan
 Suplemen nutrisi
 Anti-oksidan
 Agonis neurotransmitter
 Agonis reseptor
 Re-uptake inhibitor Reseptor
Produksi

Re-uptake
Antidepresan Efek
konvensional samping

Ketergantungan

Ggn vaskular

Ggn psikomotor
 Aman
Alami

Alga
PROSEDUR PENELITIAN
Ekstraksi

Uji
toksisitas • Fluoxetin
Control • Imipramin
• dll

Ujicoba
hewan
• FST
• TST
Test
• OFT
Reverse • L/D ET

analysis
<Dari kiri atas, searah
jarum jam> :

-Forced Swim Test

-Tail Suspension Test
-Open Field Test
-Light/Dark Exploration
ALGA & ANTIDEPRESAN
Ilya Wang dkk,
2017
Sargassum horneri  β sitosterol

 Agonis serotonin & noradrenalin

 10-30 mg/kgBB
Forced Swim Test result
Tail Suspension Test result
Sargassum ilicifolium ekstrak kloroform
& ekstrak etanol

 Agonis GABA, serotonin, NA

 400-600mg/kgBB (ekstrak kloroform)
 400mg/kgBB (ekstrak etanol)
 Solieria filiformis lectin

 Agonis reseptor dopamin

 3-9 mg/kgBB
Forced Swim Test result
Tail Suspension Test result
Referensi
 Abreu TM, Monteiro VS, Martins ABS, Teles FB, Rivanor RLdC,
Mota EF, Macedo DS, de Vasconcelos SMM, Honorio Junior
JER, Benevides NMB. 2017. Involvement of the dopaminergic
systemin the antidepressant-like effect of the lectin isolated from
the red marine alga Solieria filiformis in mice. International
Journal of Biological Macromolecules (2018) 111 : 534-541.
 Grosso C, Valentao P, Ferreres F, Andrade PB. 2014. Bioactive
Marine Drugs and Marine Biomaterials for Brain Diseases.
Marine Drugs (2014), 12, 2539-2589; doi:10.3390/md12052539.
 Wang I, Jaiswal Y, Williams L. 2017. Marine Algae as a Source
of Prevention and Relief in Those with Depression and
Dementia. World Journal of Pharmacy and Pharmaceutical
Sciences vol 6, issue 8, 26-38.
 Yende SR, Harle UN. 2013. Antidepressant-like effect of
Sargassum ilicifolium in mice model of depression. Adv.
Pharmacol. Toxicol. 14(3) 2013, 7-13.
 Yende SR, Harle UN, Ittadwar AM. 2016. Anxiolytic activity of
marine microalgae Sargassum ilicifolium and Padina
tetrastomatica in mice. International Journal of Pharmacy and
Pharmaceutical Sciences vol.8, issue 5.
 Yin Y, Liu X, Liu J, Cai E, Zhao Y, Li H, Zhang L, Li P, Gao Y.
2017. The effect of beta-sitosterol and its derivatives on
depression by the modification of 5-HT, DA and GABA-ergic
systems in mice. Royal Society of Chemistry Advances 2018,
8, 671.
 Zhao D, Zheng L, Qi L, Wang S, Guan L, Xia Y, Cai J. 2016.
Structural Features and Potent Antidepressant Effects of Total
Sterols and β-sitosterol Extracted from Sargassum horneri.
Marine Drugs 2016, 14, 123; doi:10.3390/md14070123
 Zhen XH, Quan YC, Jiang HY, Wen ZS, Qu YL, Guan LP.
2015. Fucosterol, a sterol extracted from Sargassum
fusiforme, shows antidepressant and anticonvulsant effects.
Eur J Pharmacol 768:131-8
Terima kasih