George M. Savva, Ph.D., Stephen B. Wharton, F.R.C.Path.

,
Paul G. Ince, M.D., Gillian Forster, B.Sc., Fiona E. Matthews,
Ph.D., and Carol Brayne, M.D., for the Medical Research
Council Cognitive Function and Ageing Study

Revewer by
Bambang Daru Irwanto
1613010006
To explore the effect of age on the relationship between the
classic neuropathological features of dementia and the clinical
manifestation of dementia in a population-based cohort of the
elderly.
 2500 person (randomly)  Age 64 or older
 From 5 urban and rural centers in England and Wales
 Cohort Follow up The analysis
243 person
diagnosed
after 2 years. presented
with
 Follow up
again 6 years
after the first
here was
based on 456 dementia
follow up. The brains Neuropatholo
donated up to
entire
gical Using CERAD protocol for
research was July 2004
Alzeimer’s disease
asses 10years assesment
after baseline
Interview 1. Neuropatological lesion :
Phase ( MMSE a. diffuse plaque, neuritic
& GMS-
Population AGECAT )
plaque, neurofibrillary
selection ( tangles
2500 person
age /…. 183 2. Cortical atrophy
person 3. Vascular pathological
diagnose feature and Lewy body

d witout
dementia Staistical
analys with
logistic
regression
 In this report there are relationship between the clinical
manifestations of dementia and underlying neuropathological
findings varies with age within this population-based cohort
of brain donors.
 Research in Alzheimer’s disease is focused mainly on younger
old persons, whereas studies involving very old persons
report attenuated relationships between the pathological
features of Alzheimer’s disease and dementia.
 The association between the pathological features of
Alzheimer’s disease and dementia is stronger in younger old
persons than in older old persons. Age must be taken into
account when assessing the likely effect of interventions
against dementia on the population.
 The article does not explain criteria diagnosis for Alzheimer’s
disease.
 The article does not explain about CERAD Protocol and GMS-AGECAT

Strength
The result from this research was relate to their aim