Hormon Paratiroid

dr. Muniroh, Sp.PK

Departemen Patologi Klinik

FK UIN Syarif Hidayatullah
Jakarta
Anatomi

• Terletak didaerah leher,

dibelakang kelenjar tiroid
• Berjumlah 4 buah :
2 kelenjar paratiroid superior
2 kelenjar paratiroid inferior
 Berat : 40 mg

Guyton AC, Hall JE. Textbook of medical physiology. 8th ed. Phyladelphia,2008.p.978-90
• Secara histologi terdiri dari
:
Chief cell → Terbanyak
sekresi PTH
Oxyphil cell →

Guyton AC, Hall JE. Textbook of medical physiology. 8th ed. Phyladelphia,2008.p.978-90
 BIOKIMIA
 Sintesis di ribosom dalam
• BM : 9500
bentuk preprohormon, rantai
• Smaller compounds with as few as 34 amino
polipeptida terdiri dari 115 acids
asam amino • adjacent to the N terminus of the molecule have
also
 Dipecah menjadi prohormon • been isolated from the parathyroid glands that
( 90 asam amino) → PTH (84 exhibit
• full PTH activity. In fact, because the kidneys
asam amino) di Aparatus rapidly
golgi → Secretory granule • remove the whole 84-amino acid hormone
within
 BM : 9200 Da • minutes but fail to remove many of the
 Dibersihkan oleh hati dan fragments for
• hours, a large share of the hormonal activity is
ginjal caused
• by the fragments.

Guyton AC, Hall JE. Textbook of medical physiology. 8th ed. Phyladelphia,2008.p.978-90
STRUKTUR

• Bagian N terminal yeng terdiri

dari 34 asam amino → full PTH
activity

• C-terminal fragment

Guyton AC, Hall JE. Textbook of medical physiology. 8th ed. Phyladelphia,2008.p.978-90
Guyton AC, Hall JE. Textbook of medical physiology. 8th ed. Phyladelphia,2008.p.978-90
MAKNA KLINIS

Hipoparatiroid
 Absorbsi Ca intestinal ↓  AbsorbsiHiperparatiroid
Ca intestinal ↑
 Resorpsi Ca di tulang ↓  Resorpsi Ca di tulang ↑
 Reabsorbsi Ca ginjal ↓  Reabsorbsi Ca ginjal ↑
↓ ↓
Kadar Ca ↓/hipokalsemia Kadar Ca ↑ /hiperkalsemia
↓ ↓
Tetani, CNS excited Depresi CNS, QT interval pada
jantung ↓, konstipasi, kontraksi
dinding otot GIT ↓

Guyton AC, Hall JE. Textbook of medical physiology. 8th ed. Phyladelphia,2008.p.978-90
KASUS Karsinoma
tiroid papiler
Nn.ASP,
27 tahun

Laboratorium

 Elektrolit
 Hasil laboratorium

Interpretasikan hasil laboratorium diatas !

Hipokalsemia

Pemeriksaan laboratorium apa yang saudara sarankan !

1. Pemeriksaan hormon paratiroid

2. Pemeriksaan albumin

Jika didapatkan hasil pemeriksaan hormon paratiroid 3 pg/mL

(N: 10-60 pg/mL) dan albumin 4 g/dL ( N: 3.5 – 5.2 g/dL).
Apa interpretasi saudara pada kasus diatas ?
Hipoparatiroid