ROLE OF BIOINFORMATICS IN

MEDICAL LABORATORY
BY
UBA CHIDINMA BLESSING
MLS/14/903
SUPERVISOR: DR. ELEDO BENJAMIN ONYEMA
CO-ORDINATOR: REV. SR. ARVIN NWAKULITE
OUTLINE
 Introduction to Bioinformatics
 Scope of Bioinformatics
 Goals and Aims of Bioinformatics
 Bioinformatics in Medical Laboratory
Science
 Conclusion
 References
INTRODUCTION TO BIOINFORMATICS
Bioinformatics is an interdisciplinary field that
develops methods and software tools for
understanding biological data combining biology,
computer science, information engineering,
mathematics and statistics. Specifically, they are
defined as follows:
 Informatics: the study of the structure,
behavior, and interactions of natural and
engineered computational systems.
 Bioinformatics: the application of computer
technology to the management of biological
information.
SCOPE OF BIOINFORMATICS
Bioinformatics is one
element of a broader
transformation of biology
into a computational
science. Required skills
include;
 data management,
 statistics,
 computer programming,
and
 data visualization
Figure 1: Bioinformatics and its branches
Source: (Gygi et als,1999)
GOALS AND AIMS OF BIOINFORMATICS
 Increase in the understanding
of biological processes using
computer programs that enable
efficient access to, use and
management of, various types
of information
 Development of new algorithms
and statistical measures that
assess relationships among
members of large data sets.
 Use of algorithms and
techniques to solve formal and
practical problems arising from
biological data
Figure 2: Illustrating bioinformatics
(Jeffery, 1999.)
BIOINFORMATICS IN MEDICAL LABORATORY SCIENCE
 In experimental molecular biology, bioinformatics
techniques such as image and signal processing allow
extraction of useful results from large amounts of raw
data.
 In the field of genetics, it aids in sequencing and
annotating genomes and their observed mutations
(Sim, et al., 2012).
 In molecular biology, it aids in the comparison of
genetic and genomic data (Wong, K. C. 2016).
 In structural biology, it aids in the simulation and
modeling of DNA, RNA, proteins (Kmiecik, et al 2016)
as well as biomolecular interactions.
CONCLUSION
It can be concluded from this paper that the basic aims
of bioinformatics in medical laboratory science covers
three main areas;
 First is the storage of the biological data organized in
form of a database.
 Second is to develop tools and resources that aid in
the analysis of data.
 Third and most importantly is to exploit these
computational tools to analyze the biological data
and interpret the results in a biologically meaningful
manner.
REFERENCES
Gygi, S.P., Rist, B., Gerber, S.A., Turecek, F., Gelb, M.H., and
Aebersold, R. (1999). Quantitative analysis of complex protein
mixtures using isotope-coded affinity tags. National
Biotechnology. 17:994-999.
Jeffery, C.J., (1999). Moonlighting proteins. TIBS. 24:8-11.
Kmiecik, S.; Gront, D.; Kolinski, M.; Wieteska, L.; Dawid, A. E.;
Kolinski, A. (2016). "Coarse-Grained Protein Models and Their
Applications". Chemical Reviews. 116 (14): 7898–936.
Sim, A. Y. L.; Minary, P.; Levitt, M. (2012). "Modeling nucleic
acids". Current Opinion in Structural Biology. 22 (3): 273–278.
doi:10.1016/j.sbi.2012.03.012. PMC 4028509. PMID 22538125.
Wong, K. C. (2016). Computational Biology and Bioinformatics:
Gene Regulation. CRC Press/Taylor & Francis Group. ISBN
9781498724975
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YOU
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LISTENING.