Mumtaz Ahmad, Maryam Jahangir, Muhammad Ali Shahiman Department of Urology & Renal Transplantation, Benazir Bhutto Hospital, Rawalpindi Medical University, Rawalpindi Abstract Aims & objectives • The aim of this study is to compare the safety of tubeless versus totally tubeless PCNL in terms of important postoperative clinical parameters. Materials & methods • A total of 80 patients who were candidates for PCNL with no comorbid were randomized into two groups. • 40 patients underwent tubeless PCNL in whom a 4.8fr DJ stent was placed at the end of the procedure . • 40 patients underwent totally tubeless in whom a 5fr open ended ureteric catheter was placed and kept for 24 hours. • Postoperative fever, flank pain, hematuria, urinary leakage and any infection requiring additional antibiotic coverage were recorded on a well-structured proforma for each patient. Results • From January 2017 to October 2017 80 patients who underwent PCNL were divided into two groups tubeless PCNL (n=40) and totally tubeless PCNL (n=40). • Mean age, mean BMI and mean stone size was comparable among two groups . • The mean operative time was 42.3 minutes in tubeless group versus 32.3 minutes in totally tubeless group. Results • Postoperative hematoma/urinoma was not observed in any group. • Regarding the postoperative pain , mean visual analogue score was 3 In the tubeless versus mean 1.8 in the totally tubeless group. • Postoperative fever was observed in 20% of patients with DJ-Stent versus 12.5% with totally tubeless PCNL Results • Mild hematuria was observed in 7.5% of tubeless group versus 2.5% of the totally tubeless group . • Average rise in TLC was 4300/cmm in tubeless versus 2700/cmm in the totally tubeless group. • Infections required additional antibiotics was 7.5 versus 5 in the tubeless & totally tubeless group. • Soakage was not found in any case of tubeless group, however it was observed in 5% of patients with totally tubeless PCNL Conclusion • In our study totally tubeless PCNL when compared to the Tubeless PCNL was associated with less operative time, less postoperative pain, fever, hematuria, infection. • However, tubeless PCNL had a less postoperative leakage and soakage of dressing probably due to improvrd renal drainage. • In our opinion totally tubeless PCNL is an excellent and importantly a safe modification of the conventional procedure and should be employed in routine.