Peritonitis

PRESENTAN :
FAUZAN AKBAR YUSYAHADI| 12100118191

Preceptor :
Liza Nursanty, dr., Sp.B., FinaCS., M.Kes.
definition

 Inflammation of the visceral and

parietal peritoneum, is most often
but not always infectious in origin,
resulting from perforation of a
hollow viscus. The inflammation can
be localized or diffuse.
epidemiology

 The incidence of peritonitis in America in 2011 was

about 750 thousand / year. Every hour there are
25 patients suffering from shock and 1 in 3 patients
shock ends with death.
 In 2008, in Indonesia about 7% of the population /
about 179,000 people suffered peritonitis.
Common causes: perforation appendicitis,
perforation of abdominal typhus, viscous hollow
organ trauma.
Risk factor

 Peritoneal dialysis. Peritonitis is common among

people undergoing peritoneal dialysis therapy.
 Other medical conditions. The following medical
conditions increase your risk of developing
peritonitis: cirrhosis, appendicitis, Crohn's disease,
stomach ulcers, diverticulitis and pancreatitis.
 History of peritonitis. Once you've had peritonitis,
your risk of developing it again is higher than it is
for someone who has never had peritonitis.
classification

 Primary Peritonitis
 Primary peritonitis occurs when
microbes invade the normally sterile
confines of the peritoneal cavity via
hematogenous dissemination from a
distant source of infection or direct
inoculation.
 This process is more common among
patients who retain large amounts of
peritoneal fluid due to ascites, and in
those individuals who are being treated
for renal failure via peritoneal dialysis.
 Secondary Peritonitis
Secondary peritonitis occurs subsequent to
contamination of the peritoneal cavity due to
perforation or severe inflammation and infection of
an intra-abdominal organ.
Examples include appendicitis, perforation of any
portion of the gastrointestinal tract, or diverticulitis.
 Tertiary (persistent) peritonitis.
 Patients in whom standard therapy fails then
develop an intra-abdominal abscess, leakage from
a GI anastomosis leading to postoperative
peritonitis
 Even with effective antimicrobial agent therapy, this
disease process is associated with mortality rates in
excess of 50%.
Clinical features
Hypotension
and tachycardia
Acute abdominal pain and tenderness
Fever
Locationof the pain depends on the underlying cause
and whether the inflammation is localized or generalized.
Rigidity of abdominal wall
Absent of bowel sound
Sign of dehydration
Leukocytosis at laboratory findings
Plain abdominal film may show dilation of large and small bowel
with edema of the bowel wall. Free air under the diaphragm is
associated
with a perforated viscus.
Diagnosis

The diagnosis is established based on

Identification of risk factors
Physical examination that reveals diffuse
tenderness and guarding without localized findings
Absence of pneumoperitoneum on an imaging
study
The presence of more than 100 WBCs/mL (100,000
WBCs/mm3), and microbes with a single morphology
(or double) on Gram’s stain performed on fluid
obtained via paracentesis.
Management

1. Hemodynamic Resuscitation
Aggressive fluid resuscitation to treat intravascular fluid depletion
should be instituted. Fluid administration requires frequent
monitoring of blood pressure, pulse, urine output, blood gases,
hemoglobin and hematocrit, electrolytes, and renal function.

2.Antibiotic therapy
The first line of empiric treatment is with a third-generation
cephalosporin because the majority of cases are caused by
aerobic gram-negative microbes such as E. coli, although Gram
stain and culture results should be used to guide therapy.
Management

 Satisfactory outcomes are achieved with 12 to 24 hours of

therapy for penetrating gastrointestinal trauma in the
absence of extensive contamination
 3 to 5 days of therapy for perforated or gangrenous
appendicitis
 5 to 7 days of therapy for treatment of peritoneal due to a
perforated viscus with moderate degrees of
contamination
 7 to 14 days of therapy to adjunctively treat extensive
peritonitis or that occurring in the immunosuppressed host.

Complete assurance that infection has been eradicated :

 The absence of an elevated white blood cell (WBC) count
 Lack of band forms of PMNs on peripheral smear
 Lack of fever (<100.5°F)
Empirical antibiotic therapy
Management
3. Nutrition
In general, patients with peritonitis develop some degree of gut
dysfunction (eg, ileus) after exploration. Enteral nutrition has been
found to have fewer complications in patients who are severely ill.
Nutritional demands increase during sepsis, with caloric
requirements of 25-35 kcal/kg/d.

4.Surgical – Laparotomy
Operative treatment of peritonitis has three main goals:
- To eliminate the source of contamination
- To reduce the bacterial inoculum
- To prevent recurrent or persistent sepsis
Preoperative Preparation
Volume resuscitation and the prevention of secondary organ
system dysfunction are of the utmost importance in the
treatment of patients with intra-abdominal infections.
Depending on the severity of the disease, placement of Foley
catheters may be indicated to monitor urine output.
Any existing serum electrolyte disturbances and coagulation
abnormalities should be corrected to the extent possible before
any intervention.
Empiric, broad-spectrum, systemic antibiotic therapy should be
initiated as soon as the diagnosis of intra-abdominal infection is
suspected, and therapy should subsequently be tailored
according to the underlying disease process and the culture
results.
Because patients with peritonitis often have severe abdominal
pain, adequate analgesia with parenteral narcotic agents
should be provided as soon as possible.
In the setting of significant nausea, vomiting, or abdominal
distention caused by obstruction or ileus, nasogastric
decompression should be instituted as soon as possible.
In patients with evidence of septic shock or altered mental
status, intubation and ventilator support should be considered at
an early stage to prevent further decompensation.
Complication

Left untreated, peritonitis can extend beyond

peritoneum, where it may cause:
 A bloodstream infection (bacteremia).
 An infection throughout your body (sepsis). Sepsis
is a rapidly progressing, life-threatening condition
that can cause shock and organ failure.
Prognosis

• Mortality rates are <10% for

uncomplicated peritonitis
• Mortality rates are >40% have been
reported for elderly people, those with
underlying illness, and when peritonitis
has been present for >48h
Terima kasih
Daftar pustaka

 Seymour I. Schwartz, MD., F.A.C.S. Schwartz’s,

Principles of Surgery. 9th Edition. McGraw-Hill. 2010.
 Skipworth, R.J.E., 2007. Acute abdomen :
peritonitis. , pp.1–4.
 T. R. Harrison, MD. Harrison’s, Principles of Interna
Medicine. 19th edition. McGraw-Hill. 2015
 Szeto, CC., Piraino, B., Arteaga, JD. ISPD Peritonitis
Recommendation : 2016 update on prevention
and treatment. 2016
 Longo, D.L ., Fauci, A.S. Harrison’s
Gastroenterology and Hepatology. McGraw-Hill.
2010