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menyebabkan maur.
Ia menyebabkan iritasi pada kulit, membran
mukosa serta menyebabkan rasa terbakar di dalam
mulut dan gaster.
Ia juga boleh menyebabkan pengulseran setempat.
Kesan utama termasuklah edema pulmonari
akibat alveolitis, kegagalan ginjal, nekrosis hepar
dan seterusnya fibrosis paru-paru yang progresif
serta kegagalan pernafasan.
DEFINISI
N,N'-dimethyl-4,4'-bipyridinium dichloride
Paraquat (dipyridylium) is a highly toxic weed &
grass killer ~ Herbicide
Poisoning : swallowing or breathing in Paraquat
Cause lung damage & inflammation mucosa
lining of GIT
Diagnosis of paraquat poisoning
1. History of paraquat ingestion – from
patients or other observers
2. Evidence of paraquat ingestion (suicide
note, empty container, residue,odour or
colour).
3. Clinical signs, especially with intractable
vomiting, or inflammation or ulceration of
mucous membranes (which occurs several
hours following ingestion)
CIRI-CIRI KLINIKAL
IRRITASI KULIT DAN MEMBRAN MUKOSA
PERUBAHAN PADA BENTUK MORPHOLOGI KUKU
EPISTAXIS
KECEDERAAN COMEAL
LAKRIMASI
ULSER BIBIR
TANDA KEBAKARAN DAN ULSERASI PADA LIDAH
SERTA FARINKS
ULCERASI OESOPHAGEAL
PERFORASI OESOPHAGEAL
OEDEMA PULMONARI
KEGAGALAN JANTUNG
KEGAGALAN GINJAL
KEGAGALAN HEPAR
KONVULSI
MAUT
PAIN AND SWELLING OF THE MOUTH AND
THROAT
NAUSEA, VOMITING, ABDOMINAL PAIN, AND
DIARRHEA
DIFFICULTY BREATHING
SEIZURES
SHOCK
SHORTNESS OF BREATH
CIRI-CIRI KLINIKAL
Effects within several days to several weeks:
Liver failure
Kidney failure
Heart failure
Lung scarring
CIRI-CIRI KLINIKAL
Mild or subacute poisoning:
<20 – 30 mg paraquat ion/kg body weight.
- Asymptomatic or vomiting and diarrhoea.
- Renal and hepatic lesions are minimal or absent.
- An initial decrease of the pulmonary diffusion capacity
may be present.
- Complete recovery would be expected.
CIRI-CIRI KLINIKAL
Moderate to severe acute poisoning:
>20 – 30 but <40 – 50 mg paraquat ion/kg body weight.
- immediate: vomiting.
- hours: diarrhoea, abdominal pain, mouth and throat
ulceration.
- one to four days: renal failure, hepatic impairment,
hypotension and tachycardia.
- one to two weeks: cough, haemoptysis, pleural effusion,
pulmonary
Survival is possible, but in the majority of cases death occurs
within 2 – 3 weeks from pulmonary failure.
CIRI-CIRI KLINIKAL
Fulminant: >40 – 55 mg/kg mg paraquat ion/kg body
weight.
- immediate: vomiting
- hours to days: diarrhoea, abdominal pain, renal
and hepatic failure, gastrointestinal ulceration,
pancreatitis, toxic myocarditis, refractory
hypotension, coma, convulsions.