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Hemostasis
By: Tom Anthony A. Tonguia, RMT
Historical background of hemostasis
• Today
• PT (Prothrombin time)
• APTT (Activated Partial Thromboplastin Time)
• Used to assess the activity of the reactants involved in the coagulation
mechanism
Overview of hemostasis
Events Comments
Step 1 Vasoconstriction
Step 2 Platelet Adhesion
Step 3 Platelet Aggregation
Step 4 Fibrin-Platelet Plug Formation
Step 5 Fibrin Stabilization
Role of coagulation in hemostasis
• Hypocoagulation
• Hemophilia is a well-known example of an inherited hypocoagulable
disorder.
• Patients with hemophilia have a defective coagulation mechanism that is
unable to form adequate clots, resulting in excessive bleeding from cuts.
• Hypercoagulation (thrombosis)
• Associated with the inappropriate formation of thrombi in the vasculature
that occludes normal blood flow.
• It is caused by a defect in or lack the fibrinolytic system.