Different types of smart nanogel for

targeted delivery // Journal of Science:

Advanced Materials and Devices


David Asmaryan mst1738

Karampet Giavasian mst1795

Georgios Ntagkinis mst1798
 Overview

Introduction

Single stimuli responsive nanogels

Dual stimuli responsive nanogels

Core-shell nanogels

Functionalised nanogels

Degradable nanogels

Photo-sensitive nanogels

Conclusion and future perspective

References
 Introduction

Nanotechnology

Smart Materials Nanogels Biology

 Single stimuli responsive nanogels

pH responsive Magnetic field

Temperature responsive
responsive
Dual stimuli responsive nanogels

Temperature and pH pH and magnetic field

responsive responsive
 Core-Shell nanogels

Activated
Cross-linked NIPAM C11H10O4 Core-Shell Tumour Temperature Drug
nanogel nanogel Release
Polymerisation Acidic pH levels
Mechanism
 Functionalised nanogels

Interior group
Cross-linked ATR Polymerisation Functionalisedand chain end editing Novel
nanogel with biotin,pyrene nanogel Featuring biotin,pyrene Biomaterials
and peptides peptides and GRGDS
 Degradable nanogels

Regular nanogel
mode of action

+

Multi-stimuli action


Biocompatibile and non-immunogenic


Flexible circulation to targeted area
 Photo-sensitive nanogels

Photo-sensitive
nanogel

UV or IR irradiation,
depending on Regulated
compounds used pH sensitivity
for desired action

Enduring
and complete
drug release
 Conclusion and future perspective


Wide array of functions possible with novel nanogels


Extended list of combined stimuli nanogels in the future


Issues to be addressed: Untimely delivery of drug while reducing
chemical agents and remote control release
 References

Quereshi M.A, Khatoon F., (2019), Different types of smart nanogel
for targeted delivery, Journal of Science: Advanced Materials and
Devices, Volume 4, Issue 2 pp.201-212 in
https://www.sciencedirect.com/journal/journal-of-science-advanced-
materials-and-devices/vol/4/issue/2 (Accessed in 12/11/2019)