ROGER DAVID KORNBERG

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College Class XI-G "HCC"
 Roger David Kornberg (born April 24 1947) is an
American biochemist and professor of biology at
Stanford University School of Medicine.
 Kornberg received the Nobel Prize for Chemistry in
2006 for his studies of the process by which genetic
information from DNA is copied to RNA, "the
molecular basis of eukaryotic transcripts.“
 Kornberg was born in St. Louis, Missouri, the eldest of
three sons biochemist Arthur Kornberg, who won the
Nobel Prize, and Sylvy Ruth (Levy), who was also a
biochemist. He won licensee in chemistry from
Harvard University in 1967 and Ph.D. in physical
chemistry from Stanford in 1972.


Kornberg and his father, Arthur
 Kornberg became a fellow postdoctoral research at the
Laboratory of Molecular Biology in Cambridge,
England and then an assistant professor of biological
chemistry at Harvard Medical School in 1976, before
moving to his current position as professor of
structural biology at Stanford Medical School in 1978.
 Discoveries:
 Kornberg and his research group  The structure of a
have made several fundamental
discoveries concerning the phospholipid:
mechanism and regulation of
eukaryotic cell transcripts. He
found "flip-flop" and lateral
spreading phospholipid bilayer
membranes. In 1970, Kornberg
discovered the nucleosome as the
basic protein complex
chromosomal .In both the
nucleosome, Kornberg found
that about 200 bp of DNA are
wrapped around a histone
protein octamer.
 Kornberg has made a breakthrough that consists in
sending signals that the regulatory gene called
Mediator.
   As noted by the Nobel Prize committee, "the great
complexity of eukaryotic organisms is actually enabled
the smooth interaction between tissue-specific
substances, enhancers in the DNA and mediator."
 The discovery of Mediator is therefore a true milestone
in understanding the process of transcription.
 At the same time, what Kornberg watched
these biochemical studies of the transcription
process, he devoted two decades to the
development of methods to visualize the
atomic structure of RNA polymerase protein
and its associated components.
 He recently extended these studies to obtain
structural images of RNA polymerase
associated with accessory proteins. Through
these studies, Kornberg has created a true
picture of how transcription works at a
molecular level to another.
 Personal life:
 Kornberg has two younger brothers: Thomas B.
Kornberg (b. 1948), a biochemist who characterized
and purified DNA and Kenneth Andrew Kornberg
(n.1950) an architect specializing in the design of
biomedical and biotechnology laboratories and
buildings.
 Lorch Yahli is married teacher with whom he has three
children, two boys and a girl: Guy, Gil and Maya

Thank you!