INTRODUCTION:-

 Infection occur frequently in the neonate,

causing illness . There are several reasons
for the neonate to get infection like the
variety of organisms usually present in the
uterus during gestation, in the cervix and
vagina during delivery, and in the
environment of hospital and community
DEFINITION:-
- Neonatal infection are
infection of the neonate
acquired during prenatal
development or in the first
four weeks of life(neonatal
period.)
- Neonatal infection may
be contracted by mother to
child transmission, in the
birth canal during
childbirth, or contracted
after birth.
RISK FACTORS:-
 Rapture of membranes > 18 hours
 Maternal intrapartum fever > 100.4 F
 LBW < 2500 g
 Prematurity < 37 weeks
 Chorioamnionitis
 Repeated vaginal examination in labor
 Mother with gr.B bita haemolytic
steptococcal infection (GBS)
 Male infants
MODE / SITE OF INFECTION:-
INFECTION

ANTENTAL POSTNATAL

INTRANATAL
1) ANTENATAL :
 - Transplacental
 - amnionitis
2) INTRANATAL:-
 Aspiration of infected liquor or meconium following rupture of
membrane or repeated internal examination.
 While the fetus is passing through the infected birth passage ;
 A) eyes are infected – opthalmia neonatrum or
 B) oral thrush with candida albicans .
 Improper asepsis while caring the umbilical cord.
3) POSTNATAL :-
- Nosocomial infections :- transmission due to human contact.., cross
infection , infection through …
SIGN & SYMPTOMS:-
DIAGNOSIS

 LAB TEST:  IMAGING STUDIES:

CBC X- ray
Platelet count Renal ultrasound
Blood culture
Urine culture
C- reactive protein
PREVENTION:-
 Avoiding unnecessary separation of the newborn from
the mother e.g.. baby unit
 Hand-washing before delivering and handling the infant
 Good basic hygiene and cleanliness during delivery
 Appropriate umbilical cord care
 Appropriate eye care
 Give prophylactic antibiotics only to neonates with
documented risk factors for infection.
 Give IM or IV ampicillin and gentamicin for at least 2
days and reassess; continue treatment only if there are
signs of sepsis (or a positive blood culture).
TREATMENT:-

 ANTIBIOTIC THERAPY:-
- Ampiclinie – 150mg/kg/every 12 hr
Gentamicin – 3-4 mg/kg/every 24 hours
In a severely ill patient, cefotaxime or
ceftazidime is also added.
Supportive care
Management of complication like…
A) Mechanical ventilation for RDS
B) Dopamine for hypotension
c) Anticonvulsant for seizure
d) Sodium bicarbonate for metabolic acidosis
e) Immunotherapy with hyper immune
globulins
THANK YOU