Pathogenesis of COPD

Name
Institution
 Points To Be Discussed In The
Presentation
Mechanism of action of inflammation
Role smoking plays in the pathogenesis
of COPD
Number of smokers who develop COPD
Conclusion
Introduction
 The patient is suffering from COPD
 Smokinghas been associated with being key cause
of COPD but the patient does not smoke
 The major cause can be associated to chronic
inflammation
 COPD is characterised by inflammation of the
airways, pulmonary parenchyma and pulmonary
vasculature
Mechanism Of Action Of Inflammation

 Inflammation leads to;

narrowing and fibrosis of the airways
hypersecretion of mucus in the bronchial tree
Deterioration of the vascular system
destruction of the parenchyma
 oxidative stress and other processes
follow thus participating in the
development of the disease
Role Smoking Play In Pathogenesis Of COPD

It activates
macrophages
It leads to increased
oxidative stress
Number Of Smokers Who Develop COPD

 Few smokers develop COPD despite being

cited as being responsible for increased
pulmonary inflammatory response in COPD
 However, only very few smokers develop
COPD
 The reasons are still unkown
Conclusion

 Chronic inflammation is the leading cause

of COPD
 Smokinghas been found to initially being
the cause of inflammation which lead to
COPD
 Evidenceshows very few smokers develop
COPD for reasons not known
References

 Agustí, A., & Hogg, J. C. (2019). Update on the pathogenesis of chronic obstructive pulmonary
disease. New England Journal of Medicine, 381(13), 1248-1256.
 Hogg, J. C., Paré, P. D., & Hackett, T. L. (2017). The contribution of small airway obstruction to
the pathogenesis of chronic obstructive pulmonary disease. Physiological reviews, 97(2), 529-552.
 Shi, J., Li, F., Luo, M., Wei, J., & Liu, X. (2017). Distinct roles of Wnt/β-catenin signaling in the
pathogenesis of chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. Mediators
of inflammation, 2017.
 Vogelmeier, C. F., Criner, G. J., Martinez, F. J., Anzueto, A., Barnes, P. J., Bourbeau, J., ... &
Frith, P. (2017). Global strategy for the diagnosis, management, and prevention of chronic
obstructive lung disease 2017 report. GOLD executive summary. American journal of respiratory and
critical care medicine, 195(5), 557-582.
 Wang, L., Hao, K., Yang, T., & Wang, C. (2017). Role of the lung microbiome in the pathogenesis of
chronic obstructive pulmonary disease. Chinese medical journal, 130(17), 2107.
 Zhai, T., Li, S., Hu, W., Li, D., & Leng, S. (2018). Potential micronutrients and phytochemicals
against the pathogenesis of chronic obstructive pulmonary disease and lung cancer. Nutrients,
10(7), 813.