Writing Problem and Hypothesis

Statements for Medical Research(13)

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Setting of work proposal :
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Work problem :
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Quantitative specification of problem :

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Importance of problem :
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Project need : ,
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Work objective : ?
Methodology to achieve objective
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Anticipated results :
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Contribution to field :
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Measuring physiological signals plays an important role in
medical or clinical studies, as evidenced by numerous electrophysiological
studies attempting to acquire various physiological signals emitted from pain in
order to develop adequate monitoring and recording systems.
Despite the abundance of electrophysiological investigations in this area, no
objective and precise method is available to evaluate pain in clinical practice.
(NOTE : Add 3 -4 sentences that describe characteristics of the problem or
statistics that reflect its severity) For instance, conventionally
adopted electrophysiolgical systems have only a single channel, thus
expending considerable time. The ability to use multi-channel recording
systems would not only save experimental time, but also detect the
reproducibility of the recordings without delay. The inability to
construct a standardized, multi-channel system makes it impossible to
compensate for the lack of current-source-density (CSD) analysis obtained
from stimulations, without which, makes it extremely difficult to understand the
distribution of touch or pain responses. Therefore, a multi-
channel microelectrode incorporated with a customized multi-channel recording
amplifier must be analyzed to record multi-channel evoked potentials and
quantitatively evaluate clinical pain.
()
A multi-channel microelectrode incorporated with a
customized multi-channel recording amplifier can be analyzed to record
multi-channel evoked potentials and quantitatively evaluate clinical pain.
To do so, glass microelectrodes can be used to record
cerebral evoked potentials caused by electrical or mechanical stimuli.
The responsive centers can then be identified via current-source-
density (CSD) analyses. Next, a concentration can be made of sixteen
channels in one system, which consists of amplifiers and filers capable
of preventing too many falling heads. As anticipated, the
multi-channel microelectrode incorporated with a customized multi-
channel recording amplifier can markedly reduce the time required to
perform electrophysiological experiments and reproduce experiments.
While adequate monitoring and recording systems can
build up public confidence in the reliability of laboratory results, further
clinical trials of this systems can increase diagnosis efficiency and
detect diseases in their early stages for immediate treatment. (NOTE :
Add 2-4 sentences that describe more thoroughly how the proposed
method contributes to a particular field or sector)
()
Coronary artery angiography (CAG) can not divide the severity
of left main coronary artery (LMCA) with plaque or fibrous lesion, making
impossible an appropriate and immediate treatment strategy and necessitating
an alternative means of determining the severity of a lesion to prescribe such a
strategy. In practice, CAG displays coronary arteries by combining an x-ray
intensity of 100~150 kVp and 10 mAs, making it further impossible to acquire
the images of plaque and fibrous lesion with a low intensity X-ray and
explaining why the severity of the lesion is often underestimated. For
overcoming this problem, although scanning these images with intra-vessel
ultrasound (IVUS) is a feasible alternative, how to define an accurate stenosis
rate when calculating the cross-section area ratio is problematic. (NOTE : Add
3-4 sentences that describe characteristics of the problem or statistics that
reflect its severity) The reference is defined as the LMCA with
IVUS scanning. The clinical criteria value of a normal vessel cross-section area
(CSA) is defined as the percentage confident area (Mean lumen area minus 2*
standard deviation) Although the control group can be defined
as the LMCA with CAG, whether it is normal can not be determined by
comparing their CSA results. Consequently, a precise treatment strategy can
not be devised without comparing the criteria value and the abnormal value.
Therefore, the ratio of the plaque and fibrous lesion to CSA must
be determined to enable medical personnel to assess the severity of a lesion.
()
The ratio of the plaque and fibrous lesion to CSA can be
determined to enable medical personnel to assess the severity of a
lesion. To do so, severity of a lesion can be
determined based on the melanized value of the x-ray penetrating
various density materials. The vessel lumen can then be directly
scanned using IVUS and, in doing so, not only divide different stenosis
rates but also display the anatomy three-dimensionally. As
anticipated, analysis results can verify the effectiveness of IVUS
scanning in providing a safe and accurate means of diagnosing
patients, enabling medical personnel to prescribe accurate treatment
based on IVUS results. In contrast with CAG, IVUS is a
safe, immediate and precise diagnosis method that can not only
facilitate an evaluation of lesions in the LMCA, but also enable
cardiologists to effectively treat patients and, ultimately lower the
mortality rate of CAD patients and medical expenses. (NOTE : Add 2-
4 sentences that describe more thoroughly how the proposed method
contributes to a particular field or sector)
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