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Mesoderm cells become epithelial and are arranged around a small lumen
Dorsomedial Muscle cells Dermatome Ventrolateral Muscle cells Lateral somitic frontier Intra embryonic cavity
Neural tube
sclerotome
Dorsal aorta
Cells in the ventral and medial walls of the somite lose their epithelial characteristics and migrate around the neural tube and notochord, and some move into the parietal layer of lateral plate mesoderm. Collectively, these cells constitute the sclerotome. Cells at the dorsomedial (DML) and ventrolateral (VLL) region of the somite from muscles cell precursors. Cells from both regions migrate ventral to the dermatome to form the dermomyotome. VLL cells also migrate into the parietal layer of lateral plate mesoderm across the lateral somitic frontier (green line). In combination, somitic cells and leteral plate mesoderm cells constitue the abaxial mesodermal domain, while the primaxial mesodermal domain only contains somitic cells (paraxial mesoderm)
Dermatome Sclerotome
Togather, dermatome cells and the muscle cells that associate with them from the dermomytome.
The dermomyotome begins to differentiate, myotome cells contribute to primaxial muscles, and dermatome cellsform the dermis of the back.
Back (epaxial ) Muscle Dorsal primary ramus Ventral primary ramus Body wall muscles Extensor muscle of limb Hypaxial muscles
Cross section through half the embryo showing innervation to developing musculature. Epaxial (true back muscle) are innervated by dorsal (posterior) primary rami. Hypaxial muscle (limb and body wall ) are innervated by ventral (anterior) primary rami.
Poland sequence. The pectoralis minor and part of the pectoralis major muscles are missing on the patient s left side. Note displacement of the nipple and areola.
Posterior view
Forelimbs with their dermatome segments indicated. (From Moore, KL and Dalley,AF. Clinically Oriented Anatomy,5th ed.
Thoracic myotomes Mesenchymal Condensation Of limb bud Limb axis epithelial ridge Eye
Musclature in the head and neck derived from somitomeres and myotomes that form from the occipital region caudally in a 7- week embryo.
Endoderm
Transverse section through an embryo of approximately 19 days. Intercellular clefts are visible in the lateral plate mesoderm.
Section through an embryo of approximately 20 days. The lateral plate is divided into somatic and visceral mesoderm layers that line the intraembryonic cavity. Tissue bordering the intraembryonic cavity differentiates into membranes.
Amniotic cavity
Parietal mesoderm
Amniotic cavity
Surface ectoderm
The intraembryonic cavity is about to lose contact with the extraembryonic cavity.
Surface ectoderm
Dorsal mesentery
Viseral mesoderm
Gut
Parietal mesoderm
At the end of the fourth week, splanchnic mesoderm layers are continuous with somatic layers as a double-layered membrane, the dorsal mesentery. Dorsal mesentery extends from the caudal limit of the foregut to the end of the hindgut.
Endoderm Ectoderm
allantois
17 days Midsagittal sections of embryos at various stages of development showing cephalocaudal folding and its effects upon position of the heart, septum transversum, yolk sac, and amnion. Note that, as folding progresses, the open ing of the gut tube into the yolk sac narrows until it forms a thin connection, the vitelline (yolk sac)duct, between the midgut and the yolk sac
Hindgut foregut
Heart tube
Pericardial cavity
22 days.
Oropharyngeal membrane
Cloacal membrane
Heart tube
Septum transversum
24 days
Lung bud
Remnant of the Oropharyngeal membrane Allantois Septum transversum Vitelline duct Yolk sac
Pharyngeal gut Lung bud Stomodeum Liver Gallbladder Vitelline duct Allantois Primitive Intestinal loop Hindgut Stomach
Pancreas
Cloaca
Pharyngeal pouches, epithelial lining of the lung buds and trachea, liver, gallbladder, and pancreas.
Pharyngeal Pouches
Heart bulge
The urinary bladder is derived from the cloaca and, at this stage of development, is in open connection with the allantois.
Ectopia cordis. The heart lies outside the thorax, and there is cleft in the thoracic.
Gastroschisis. Intestine have herniated through the abdominal wall to the right of the umbilicus, the most common location for this defect.
Blandder
Scrotum
Bladder exstrophy. Cloure in the pelvic region has failed. In males, the defect usually a split in the dorsum of the penis, a defect called epispadius.
Cloacal exstrophy. A larger closure defect in which most of the pelvic region has failed to close, leaving the bladder, part of the rectum, and the anal canal expesed.
Amnion
Abdominal wall
Intestinal loops
Umbilical cord
Example of omphaloceles, a defect that occurs when loops of bowel, that normally herniate into the umbilical cord during the 6th to 10th week of gestation (physiological umbilical herniation), fail to return to the bodycavity.
A. Drawing showing loops of herniated bowel within the umbilical cord that have failed to return to the
abdominal cavity. The bowel is covered by amnion because this membrane normally reflects onto umbilical cord
Infant with an omphalocele. The defect is associated with other major malformations and chromosome abnormalities.
Drawing showing the ventral view of an embryo at 24 days gestation. The gut tube is closing, the anterior and posterior intestinal portals are visible, and the heart lies in the primitive pleuropericardial cavity, which is partially separated from the abdominal cavity by the septum transversum.
Liver cords
Body wall
Cloaca Portion of an embryo at approximately 5 weeks with parts of the body wall and septum transversum removed to show the pericardioperitoneal canals. Note the size and thickness of the septum transversum and liver cords penetrating the septum
Growth of the lung buds into the pericardioperitoneal canals. Note the pleuropericardial folds.
A. Transformation of the pericardioperitoneal canals into the pleural cavities and formation of the pleuropericardial membrane. Note the pleuropericardial folds containing the common cardinal vein and phrenic nerve. Mesenchyme of the body wall splits into the pleuropericardial membrane and definitive body wall. B. The thorax after fusion of the pleuropericardial folds with each other and with the root of the lungs. Note the position of the phrenic nerve, now in the fibrous pericardium. The right common cardinal vein has developed into the superior vena cave.
Septum Transversum
Development of Diaphragm
Aorta
Pleuroperitoneal folds fuse with the septum transversum and mesentery of the esophagus in the seventh week, separating the thoracic cavity from the abdominal cavity.
Pleuroperitoneal membrane
Muscular ingrowth from body wall Septum transversum Transverse section at the fourth month of development. An additional rim derived from the body wall forms the most peripheral part of the diaphragm.
Aortic hiatus Absence of pleuroperitoneal membrane Abdominal surface of the diaphragm showing a large defect of the pleuroperitoneal membrane
Left lung
Colon
Diaphragm Stomach
Hernia of the intestinal loops and part of the stomach into the left pleural cavity. The heart and mediastinum are frequently pushed to the right, and the left lung is compressed.
Radiograph of a newborn with a large defect in the left side of the diaphragm. Abdominal viscera have entered the thorax through the defect.