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  • Gerty Radnitz Cori

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    Gerty Radnitz Cori (1896 - 1957) was the first woman and married couple to be awarded The Nobel Prize in Physiology or Medicine. She was afflicted by the rare disease of Myelofibrosis - a debilitating disease of the bone marrow that slowly reduces production of RBC. She worked through her illness that lasted a decade before she succumbed to the illness in 1957 at the age of 61.

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    Gerty Radnitz Cori (1896 - 1957) was the first woman and married couple to be awarded The Nobel Prize in Physiology or Medicine. She was afflicted by the rare disease of Myelofibrosis - a debilitating disease of the bone marrow that slowly reduces production of RBC. She worked through her illness that lasted a decade before she succumbed to the illness in 1957 at the age of 61.

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    Attribution Non-Commercial (BY-NC)
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    128 vizualizări11 pagini

    Gerty Radnitz Cori

    Încărcat de

    api-3714421
    Gerty Radnitz Cori (1896 - 1957) was the first woman and married couple to be awarded The Nobel Prize in Physiology or Medicine. She was afflicted by the rare disease of Myelofibrosis - a debilitating disease of the bone marrow that slowly reduces production of RBC. She worked through her illness that lasted a decade before she succumbed to the illness in 1957 at the age of 61.

    Drepturi de autor:

    Attribution Non-Commercial (BY-NC)
    Descărcați ca PPT, PDF, TXT sau citiți online pe Scribd
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    din 11

    Gerty Radnitz Cori

    1896 - 1957

    The Nobel Prize in Physiology or


    Medicine 1947

    Picture taken from:


    http://nobelprize.org/nobel_prizes/medicine/laureates/1947/cori-gt-bio.html
    Brief Profile
    • Born in Prague and later became an
    American citizen
    • Nobel Laureate in Physiology or Medicine
    (1947)
    • For the discovery of the course of catalytic
    conversion of glycogen
    • The Cori Crater on the moon was named in
    memory of her work
    Inspiration
    • First American woman and married couple
    to be awarded the Nobel Prize
    • At the Washington Universty School of
    Medicine, her husband, Dr Carl Cori was
    the Chairperson of the Dept. of
    Pharmacology whilst she was a mere
    research assistant
    Inspiration
    • Faced immense prejudice against her
    gender
    • Husband, Dr Cori received many job offers
    but was adamant that his wife be given a
    job offer as well
    • “Find Me A Cure” – sentence that would
    later spark a undying passion to study
    Glucose metabolism
    Inspiration
    • Afflicted by the rare disease of
    Myelofibrosis – A debilitating disease of
    the bone marrow that slowly reduces
    production of RBC
    • She worked through her illness that lasted a
    decade before she succumbed to the illness
    in 1957 at the age of 61
    Gerty Cori’s Work…

    Studies on carbohydrate metabolism


    (whole animals  tissue extracts & isolated
    enzymes)
    1936 – Isolation of glucose-1-phosphate

    (Cori ester)
     discovered role of glycogen phosphorylase
    enzyme
     involved in conversion of glucose to glycogen
     Isolation & purification of enzymes involved in glycogen-
    cori ester reaction
     roles of enzymes determined

     1939 – Enzymatic synthesis of glycogen in vitro

     Studies on effect of hormones on hexokinase enzyme


     observed pituitary extracts inhibiting
    hexokinase & insulin cancels out the
    inhibition
    Influence on Current Knowledge…
     Cori Cycle

     Evidence of inter-conversion
    between muscle glycogen
    & blood glucose led to
    formulation of Cori cycle

     Hormonal influence of
    carbohydrate metabolism

     Discovery of hormones regulating glycogen


    metabolism has allowed us to understand the
    metabolism fully
     Biochemical basis to develop treatment for diabetes
    Challenges faced:
    1. Early Education
    • Home-schooled, Girls’ finishing school
    2. World War I
    • Anti-Semitism in Europe
    3. Discrimination in America
    • Finding a job, “Nepotism” rules
    • 13 years research associate (WW II irony)
    4. Health
    • Diagnosed with anemia – before
    Stockholm
    Inspiration for Other Females
    • First American woman to win Nobel Prize
    • Was marginalized in non-tenure track
    research positions at token salaries
    • Never stopped pursuing her lifelong interest
    despite gender discrimination and nepotism
    • Voracious reader, focused, hard-driving and
    tireless worker
    • Sympathetic to other women in research
    References
    • Cori, C.F. & Cori, G.T. (1947).Biography: Gerty Cori
    http://nobelprize.org/nobel_prizes/medicine/laureates/1947/cori-gt-bio.html
    • Cori, Carl; and Cori, Gerty. (2006). In Encyclopædia Britannica. Retrieved
    September 9, 2006, from Encyclopædia Britannica Premium Service:
    http://www.britannica.com/eb/article-9026290
    • http://www.squaldrina.com/links/medicine/corithe.htm
    • http://www.greatwomen.org/women.php?action=viewone&id=44
    • Nobel Prize Women in Science: Their Lives, Struggles, and Momentous
    Discoveries, Second Edition (1993)
    Joseph Henry Press (JHP)
    • Available at: http://darwin.nap.edu/books/0309072700/html/91.html

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