Probiotics for Health

Our Private Garden Tract

Meeting of

The Japanese College of IV Therapy

Tokyo, Japan February 2009

Bradford S. Weeks, MD
www.weeksmd.com

*Slides with (SFO)

are from my friend Stephen Olmstead, M.D.*

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The Intestinal Microbiota Organ (SFO)

10 meters long (average adult) Weighs 1.5 Kg

Metabolic activity rivals liver

Regulates Immune function Digests foods

Creates vitamins
Modulates acid-base
Human Colon air contrast barium enema
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The Human Intestinal Microbiota (SFO)

Our best guess

100 trillion microorganisms

10 x number human cells >100 x number human genes

>1000 genera
>500 cultured species Dominated by 2 divisions

Firmicutes and Bacteroidetes

99% anaerobic?
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Louis Pasteur Germs cause disease

Prof. Antoine Bchamp The Terrain rules.

Gaston Naessens The Somotid pleomorphism www.whale.to/cancer/naessens.html

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Naessens: The Somatid cycle

Bacteria become yeast which in turn become bacteria etc. The environment created the germs.

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Germ Theory vs. Terrain

Pasteur on his death bed: Le terrain, cest tout. The Terrain is all.

Why cows?
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Why no cows?

Germ Theory vs. Terrain

Pasteur:
Germs are present, immutable, responsible for disease.

Rx: anti-biotics and vaccines

Bchamp : Germs are pleomorphic and their presence or absence

depends upon the environment, the terrain. Rx: change the terrain

Bernard

the role of "milieu" or environment changes the mix of microorganisms as the body moves from alkaline pH to acidic pH.

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References and Further Reading

Ethel Douglas: Bechamp or Pasteur (later published as Pasteur Exposed) http://www.healthresearchbooks.com/pages/book_detail.php?pid=1102 R B Perason: The Dream and Lie of Louis Pasteur http://www.sumeria.net/dream.html The Lost History of Medicine http://www.mnwelldir.org/docs/terrain/lost_history_of_medicine.htm

Breaking the Vicious Cycle Elaine Gottschall

Sick and Tired? Robert Young

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How big is the surface area of the GI tract?

imagine flattening out all the villi to account for that surface areas
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The surface area of the GI tract = size of a tennis court?

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Same number of intestinal villi as blades of grass?

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Bigger!
The Football Field Within
Per Dr. Stephen Olmstead, M.D.

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Where is my GI tract?
It is OUTSIDE the human body. All the microorganisms live outside of us. If they entered within us, into out blood stream or tissues = death .
Probiotics and antibiotics function outside the human body.
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The Doughnut Metaphor

Man as doughnut. The hole is our intestinal lumen.

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Doughnut Metaphor
Things can pass through man and things pass through doughnuts.

But remember: The finger is never inside the doughnut.

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The most dangerous daily task!

Eating!
What would happen if you IVd the food you ate this morning for breakfast? Phlebitis? Or Anaphylaxis and death!
Eating food requires chewing, digestive enzymes and a pro-biotically balanced gastro-intestinal tract to de-animate it, reduce it to common nutritional currency

and render it safe for absorption .

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Self- vs Non Self

You are what you eat (if digestion is weak).
Frank Purdue
Chicken

Football player
Beef

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Where is your immune system

It wraps around your gut like an insulating blanket and addresses anything that leaks through threatening to enter your privated blood stream.

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Dysbiosis
Altered gut flora intoxicates all organ systems.
Leaky gut syndrome leads to these illnesses: 1) Chronic 2) Degenerative 3) Occult 4) Debilitating

Auto-immune cross reactivity:

1) Anklyosing Spondylitis and Proteus mirabilis 2) Guillain-Barr and Campylobacter jejuni
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Cross Reactivity and Dysbiosis

Cross-reactivity between the rheumatoid arthritisassociated motif EQKRAA and structurally related sequences found in Proteus mirabilis. Infection and immunity 1999;67(6):2769-75.
Tiwana H; Wilson C; Alvarez A; Abuknesha R; Bansal S; Ebringer A

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History of Probiotics
10,000 BC fermented beverages (mead)

3,000 BC yogurt
Hippocrates (460-370 BCE) Sour milk for GI disorders Pliny the Elder (23-79 CE) Natto Fermented soy Health benefits of sour milk All native cultures eat a raw or fermented food

Kombucha tea
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Probiotics Clinical Applications (SFO)

The dependence of the intestinal microbes on the food makes it possible to adopt measures to modify the flora in our bodies and replace the harmful microbes with useful microbes.

The Prolongation of Life 1907 Eli Metchnikoff Nobel laureate 1908

1848-1916
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Starve the Yeast over 3 days.

Lactobacillus Benefits (SFO)

Digest & metabolize proteins & carbohydrates Synthesize B vitamins & vitamin K Catabolize bile salts Enhance innate & acquired immunity Inhibit proinflammatory mediators Antimicrobial activities against array of pathogens:Pseudomonas, E. coli, Staph. aureus, Salmonella, Shigella, Candida & H. pylori Reduces GI concentrations of carcinogenic enzymes Antagonizes rotavirus & C. difficile Suppresses enterohemorrhagic E. coli internalization Inhibits EHEC intestinal cell adherence & invasion Decreases production of inflammatory mediators Supports intestinal barrier function Reduces translocation of gut flora

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Bifidobacterium Characteristics (SFO)

Gram-positive, non-sporulating rods or Y-shaped Strictly anaerobic & fastidious All metabolize lactose Ferment non-digestible oligosaccharides Synthesize B vitamins & vitamin K Enhance innate & acquired immunity

Inhibit proinflammatory mediators Inhibit pathogens via organic acids & H2O2 Inhibits enterotoxigenic E. coli receptor binding & translocation Inhibits Clostridium proliferation Enhances GI sIgA response to dietary antigens Modulates cytokine response to respiratory antigens

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Probioic Deficiency Syndrome (PDS)

Etiology:
Non-breast fed infants Breast fed infants from dysbiotic mothers People taking antibotics early and often People who dont eat real and raw and fermented foods People eating dairy (antacid effect) Some elderly people (loss of digestive forces)

Clinical Signs and Symtoms:

Bloating Gas , burping, flatulence GERD (gastro esophageal reflux disease) Obesity Insomnia Depression Poly-inflammatory diseases Yeast over growth Diarrhea or constipation

Saccharomyces boulardii (SFO)

Non-pathogenic yeast Heat & pH resistant Transient GI species Active ingredient in medicinal teas Increases brush border enzyme activities Secretes leucine aminopeptidase; supports against dietary protein allergies Increases short-chain fatty acid concentrations Increases intestinal sIgA; crypt cell Ig receptors Protease that inhibits C. difficle toxins A & B Antogonizes Gram (-), Candida & Entamoeba hystolytica
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Probiotic Dosing
May need to start low , go slow

(SFO)

Acid stable technology - 50-90% viability Unprotected probiotics - 10% viability Doses in the millions CFU - may not be beneficial Trend is for 100s of billion CFU 109-11 CFU tolerated by immunosuppressed patients 110 billion CFU/Kg tolerated by infants

Products available with 850 billion CFU/dose

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Probiotic Dosing (SFO)

With or without food?

Stomach pH:

fasting: 1.5

with food: 2 3
Transit time: 30 min 1 hr

Take your probiotics with food.

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Probiotics & Antibiotics

Antibiotics from Latin meaning: against life Yes. They do save lives. But the ancients taught

All illness begins in the gut.

Antibiotics cause dysbiosis (disorder biology) in gut. Antibiotics create chronic and acute illnesses.

Probiotics do not interfere with antibiotics if taken 2 hrs

before or after the antibiotic dose
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Probiotics - Documented Uses (SFO)

Antibiotic-associated diarrhea
C. difficile-associated diarrhea Community acquired diarrhea

Travelers diarrhea
Inflammatory bowel disease Irritable bowel disease Vaginal dysbiosis Urinary tract infections Allergies, atopic dermatitis, eczema Lactose intolerance Hyperlipidemia

Summary and Recommendation

1. All disease begins in the gut.

2. We (cells with our DNA) are outnumbered 10:1

3. When I reach for sugar (saki, dessert, ) it may not be me, but rather the yeast which needs to be fed their

diet of choice: fast burning carbohydrates!

4. When high-quality probiotics are used, far ranging benefits accrue in all physiological systems; 5. Not all probiotics are good quality - so buy the best! 6. Treat the gut first , the rest is less complicated.

Hes got guts.

means

He has courage

not,

He is obese!

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THE END I thank you again for your kind attention and invite any questions.
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Please feel free to EMAIL ME with questions or comments.

MD@WEEKSMD.COM 360-341-2303
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