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Description
Radiopharmaceuticals used in cancer treatment are small, simple substances, containing a radioactive isotope or form of an element. They are targeted to specific areas of the body where cancer is present. Radiation emitted from the isotope kills cancer cells. These isotopes have short half-lives, meaning that most of the radiation is gone within a few days or weeks.
Application of radiopharmaceuticals
Treatment of disease: (therapeutic radiopharmaceuticals)
Chromic phosphate P32 for lung, ovarian, uterine, and prostate cancers Sodium iodide I 131 for thyroid cancer Samarium Sm 153 for cancerous bone tissue Sodium phosphate P 32 for cancerous bone tissue and other types of cancers Stronium chloride Sr 89 for cancerous bone tissue
Chromic phosphate P 32 is a suspension that is delivered through a catheter, or tube, inserted into the sac surrounding the lungs, or into the abdominal or pelvic cavities. The usual dosage is 15-20 millicuries for abdominal administration and 10 millicuries for administration to the lung sac. Chromic phosphate P 32 also may be injected into the ovaries or prostate. Sodium Iodide I 131 is taken by mouth as a capsule or a solution. The usual dose for treating thyroid cancer is 30-200 millicuries, depending on age and body size. Doses may be repeated. Treatment usually requires two to three days of hospitalization. For this therapy to be effective there must be high levels of thyroid-stimulating hormone (TSH, or thyrotropin) in the blood. This hormone can be injected prior to treatment.
radiopharmaceuticals.
Precautions After Treatment With Radiopharmaceuticals Strontium-89, samarium Sm 153 lexidronam, and large total doses of sodium iodide I 131 may temporarily lower the
It is important to drink plenty of liquids and to urinate often after treatment with sodium iodide I 131. This flushes the radioiodide from the body. To reduce the risk of contaminating the environment or other people, the following procedures should be followed for 4896 hours after treatment is sodium iodide I 131: avoiding the handling of another person's eating utensils, etc.
I131 THERAPY PROCEDURES Minor therapies of I131 are single doses of 30 mCi or less. Major therapies of I131 are single doses greater than 30 mCi.
Handling Instructions
All I 131 should be opened under a fume hood prior to administration to a patient to allow for escape of vapor in the vial. The activity of each dosage shall be measured in a dose calibrator and verified to be within 10% of the prescribed dose. Since the exposure rate on the outside of the lead pig and shipping box may be quite high, adequate precautions must be taken when transporting sources.
Major Therapies Patients receiving major therapeutic doses of I131 must be admitted to the hospital. The patient must have a private room and bath. The room must also be approved by the Radiation Safety Office, taking into consideration areas adjacent to, above, and below where radiation levels must be within certain limits. Before the dose is administered, the room must be prepared by
Radiation Safety.
This involves covering the floor with plastic or absorbent paper and covering various articles the patient may touch such as
Patient rooms used for major therapies may not be released for use by other patients until documented surveys by Radiation Safety staff demonstrate that there is no removable contamination in excess of 200 dpm/100 cm2.
Therapeutic procedures can usually be divided into two classes: Treatment with sealed sources, which are mechanically inserted. Treatment with solutions.
Sealed sources are encapsulated and therefore the risk of contamination is very small Ex. Radiopharmaceutical Iodine-125 seeds, used to treat prostate cancer. Ex of radiopharmaceutical solutions, Iodine-131, Strontium-89
scanning).
2- Radionuclide generators.
3-Non-radioactive components (kits) for the preparation
Radiopharmaceutical products include inorganic compounds, organic compounds, peptides, proteins, monoclonal antibodies and fragments and oligonucleotides labeled with radionuclide
There are three units related to radiation: ( R) the roentgen for exposure Is the amount of x or radiation that produces ionization of one electrostatic unit of either positive or negative charge per cubic centimeter of air at 0 C and 760 mmHg.
The basic unit for quantifying radioactivity (i.e. describes the rate at which the nuclei decay).
Curie (Ci):
A unit of radioactivity. A curie is defined as 3.7 x 1010 disintegrations per second. In 1980, The new basic unit for quantifying radioactivity. Becquerel (Bq):
Generator, Radionuclide:
is separated from
Half-Life (Tl/2):
A unique characteristic of a radionuclide, defined by the time during which an initial activity of a radionuclide is reduced to one half. It is related to the decay constant () by tl/2 = 0.693/.
Hot Cell
A lead shielded total containment cabinets providing an environment of different classes. Ionization Chamber: A gas-fi1led instrument used to measure radioactivity or exposure in terms of ion pairs produced in gas by radiations. Isotopes: Nuclides having the same atomic number, that is, the same number of protons in the nucleus, but different number of neutrons. Examples are 14C 6 and 12C6 .
Labeled Compound:
Radionuclide Purity:
The fraction of the total radioactivity in the form of the stated radionuclide. Any extraneous radioactivity such as 99Mo in
99mTc-radiopharmaceuticals
is an impurity.
Radiopharmaceutical:
Sievert (Sv):
The unit of absorbed dose equivalent and equal to 100 rem.
Standard operating procedure (SOP): An authorized written procedure giving instructions for
environmental control; sampling and inspection). Certain SOPs may be used to supplement product-specific master and
Target Material A chemical substance which is bombarded with nuclear particles to produce a desired radionuclide.
Tracer A radionuclide or a compound labeled with a radionuclide that may be used to follow its distribution or course through
Services
Biological Safety Chemical Safety EHOS Fire safety Chemical Safety
Fire safety
Radiation safety
Biological Safety
Radiation safety
EHOS
The
regulatory
procedures
necessary
to
control
radiopharmaceutical products are in large part determined by the source of these products and methods of manufacture. Manufacturing procedures within the scope of these guidelines include: The manufacturing of radiopharmaceuticals in centralized radiopharmacies. The manufacturing of radiopharmaceuticals in nuclear and institutes and industrial manufacturers. The manufacturing of radiopharmaceuticals in positron emission tomography (PET) centers.
Introduction Radiopharmacys prime responsibility is the preparation of high quality, radioactive, medicinal products for use in diagnosis and therapy. Our products are Medicines and are made under the terms of a Department of Health Manufacturing Specials license. Our manufacturing facility in Medical Physics is an aseptic suite designed