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of blood vessels: Arteries (and arterioles) carry blood away from the heart Capillaries where nutrient and gas exchange occur Veins (and venules) carry blood toward the heart.
Blood vessels
The Arteries
Arteries and arterioles take blood away
from the heart. The largest artery is the aorta. The middle layer of an artery wall consists of smooth muscle that can constrict to regulate blood flow and blood pressure. Arterioles can constrict or dilate, changing blood pressure.
The Capillaries
Capillaries have walls only one cell thick to allow
exchange of gases and nutrients with tissue fluid. Capillary beds are present in all regions of the body but not all capillary beds are open at the same time. Contraction of a sphincter muscle closes off a bed and blood can flow through an arteriovenous shunt that bypasses the capillary bed.
The Veins
Venules drain blood from capillaries,
then join to form veins that take blood to the heart. Veins have much less smooth muscle and connective tissue than arteries. Veins often have valves that prevent the backward flow of blood when closed. Veins carry about 70% of the bodys blood and act as a reservoir during hemorrhage.
circuits: 1) Pulmonary circuit which circulates blood through the lungs, and 2) Systemic circuit which circulates blood to the rest of the body. 3) Both circuits are vital to homeostasis.
pulmonary trunk from the right ventricle which branches into two pulmonary arteries that take oxygen-poor blood to the lungs. In the lungs, oxygen diffuses into the blood, and carbon dioxide diffuses out of the blood to be expelled by the lungs. Four pulmonary veins return oxygen-rich blood to the left atrium.
carrying O2-rich blood from the left ventricle. The aorta branches with an artery going to each specific organ. Generally, an artery divides into arterioles and capillaries which then lead to venules.
has the same name as the artery that delivered blood to the organ. In the adult systemic circuit, arteries carry blood that is relatively high in oxygen and relatively low in carbon dioxide, and veins carry blood that is relatively low in oxygen and relatively high in carbon dioxide. This is the reverse of the pulmonary circuit.
Blood Flow
The beating of the heart is necessary to
homeostasis because it creates pressure that propels blood in arteries and the arterioles. Arterioles lead to the capillaries where nutrient and gas exchange with tissue fluid takes place.
heart accounts for the flow of blood in the arteries. Systolic pressure is high when the heart expels the blood. Diastolic pressure occurs when the heart ventricles are relaxing. Both pressures decrease with distance from the left ventricle because blood enters more and more arterioles and arteries.
because there are more capillaries than arterioles. This allows time for substances to be exchanged between the blood and tissues.
Venous blood flow is dependent upon: skeletal muscle contraction, presence of valves in veins, and respiratory movements. Compression of veins causes blood to move forward past a valve that then prevents it from returning backward.
Venous blood flow is dependent upon: skeletal muscle contraction, presence of valves in veins, and respiratory movements. Compression of veins causes blood to move forward past a valve that then prevents it from returning backward.
that occur with breathing also assist in the return of blood. Varicose veins develop when the valves of veins become weak. Hemorrhoids (piles) are due to varicose veins in the rectum. Phlebitis is inflammation of a vein and can lead to a blood clot and possible death if the clot is dislodged and is carried to a pulmonary vessel.
pressure of around 90 mmHg This helps push the blood from the arteries into the capillaries
In the capillaries, oxygen transfers from the
mmHg
Maximum systolic pressure is typically 110-
120 mmHg
Race Orientals > Westerns ? dietry factors, or weather. Sleep due to venous return. Pregnancy due to metabolism.
BP depends on:
More cells
Regulation of ABP:
Maintaining B.P. is important to ensure a steady blood
oblongata:
1. Vasomotor Center (V.M.C.), or (pressor area): Sympathetic fibers. 2. Cardiac Inhibitory Center (C.I.C.), or (depressor area): Parasympathetic fibers (vagus).
Regulation of ABP
(continued)
Concerned by controlling CO (SV, HR), & PR. Concerned mainly by regulating the blood volume.
Regulation of CO:
A fast acting mechanism. CO regulation depends on the regulation of:
a. Stroke volume, & b. Heart rate
Regulation Of COP
COP = SV X HR
HR : Sympatic /parasympatic SV : Venous return, Contractility
Baroreceptors
How does the body know that there has been a fall in blood pressure?
Baroreceptors on the aorta and carotid artery
respond to falls in BP
The medulla sends signals along the sympathetic nerves to the arterioles and heart, increasing SVR and cardiac output
1. Baroreceptors reflex:
Baroreceptors are receptors found in carotid sinus & aortic arch. Are stimulated by changes in BP.
BP + Baroreceptors
= V.M.C
= Sympathetic Vasodilatation & TPR
++ C.I.C
+ Parasympathetic Slowing of SA node ( HR) & CO
2. Chemoreceptors reflex:
Chemoreceptors are receptors found in carotid &
aortic bodies. Are stimulated by chemical changes in blood mainly hypoxia ( O2), hypercapnia ( CO2), & pH changes.
Haemorrhage
BP
Hypoxia
++ V.M.C
+ Adrenal medulla + Sympathetic Vasoconstriction & TPR
+ Chemoreceptors
= C.I.C
= Parasympathetic
HR
3. Pulmonary receptors:
Lung inflation vasoconstriction.
4. Hormonal Agents:
NA vasoconstriction. A vasoconstriction (except in sk. ms.). Angiotensin II vasoconstriction. Vasopressin vasoconstriction.
1. Renin-Angiotensin System:
Most important mechanism for Na+ retention in order to maintain the blood volume. Any drop of renal blood flow &/or Na+, will stimulate volume receptors found in juxtaglomerular apparatus of the kidneys to secrete Renin which will act on the Angiotensin System leading to production of aldosterone.
Renin-Angiotensin System:
renal blood flow &/or Na+ ++ Juxtaglomerular apparatus of kidneys (considered volume receptors) Renin Angiotensinogen Angiotensin I
(Lungs) Converting enzymes
Angiotensin III
(powerful vasoconstrictor)
Angiotensin II
Corticosterone