Cerinte studiu individual

Alctuiti un referat de 4-10 pagini care s cuprind:

1. 2. 3. 4. 5. mecanismele moleculare implicate in functionarea medicamentului i penetrana polimorfismului / mutaie biomarkerului aplicatii clinice ale medicamentului evaluarea cost-beneficiu raporturi de ncercare comercializate biomarker (dac exist); gsii companie de marketing de testare, precum i interpretarea a rezultatelor testelor (de exemplu, cum sunt rezultatele folosite pentru ghidarea in terapie, i pe ce dovezi) Bibliografie conform formatului:
Lorena Aranbacia Carcamo, 2006. Studying the Localization Surface, Stability And Endocytosis of Neurotransmitter Receptors by Antibody Labeling and Biotinylation Approaches from The dinamyc Synapse Molecular methods in Ionotropic Receptors Biology. Taylor & Francis Goup (http://www.ncbi.nlm.nih.gov/books/NBK2552/) P. James, 1997. "Protein identification in the post-genome era: the rapid rise of proteomics.". Quarterly reviews of biophysics 30 (4): 279331.

Fiecare student va avea un medicament din lista. Termen de predare material 20. 12. 2012 Vor fi predate in format electronic la eful de grup (acesta va trece materialul pe un CD (doc, docx) pe care-l va preda cadrului didactic) Parola pentru platform curs este PGX2012 http://ovidiusfarma.freehostia.com/biologie/ Va rog s v crea i cont nou! Aici vor fi introduse si adresele de unde pute i consulta bibliografie pentru curs i aplicaia pentru evaluare.

Titular curs Sl.Dr. Schrder Verginica

Pharmacogenomic Biomarkers in Drug Labels Drug 1. Abacavir3 2. 3. Arsenic Trioxide5 4. Atomoxetine6 5. Atorvastatin7 6. Azathioprine8 7. 8. Brentuximab Vedotin10 9. 10. 11. 12. 13. 14. Busulfan11 Capecitabine12 Carbamazepine13 Carisoprodol14 Carvedilol15 Celecoxib16 Oncology Oncology Oncology Neurology Musculoskeletal Cardiovascular Analgesics CD30 Ph Chromosome DPD HLA-B*1502 CYP2C9 CYP2D6 CYP2C9 Rheumatology TPMT Metabolic and Endocrinology LDL receptor Psychiatry CYP2D6 Oncology PML/RAR Antivirals HLA-B*5701 Therapeutic Area Biomarker Label Sections Boxed Warning, Contradindications, Warnings and Precautions, Patient Counseling Information Clinical Pharmacology Boxed Warning, Clinical Pharmacology, Indications and Usage, Warnings Dosage and Administration, Warnings and Precautions, Drug Interactions, Clinical Pharmacology Indications and Usage, Dosage and Administration, Warnings and Precautions, Clinical Pharmacology, Clinical Studies Dosage and Administration, Warnings and Precautions, Drug Interactions, Adverse Reactions, Clinical Pharmacology Clinical Pharmacology Indications and Usage, Description, Clinical Pharmacology Clinical Studies Contraindications, Precautions, Patient Information Boxed Warning, Warnings and Precautions Clinical Pharmacology, Special Populations Drug Interactions, Clinical Pharmacology Dosage and Administration, Drug Interactions, Use in Specific Populations, Clinical

Aripiprazole4

Psychiatry

CYP2D6

Boceprevir9

Antivirals

IL28B

Drug 15. Cetuximab (1)17 16. 17. 18. 19. 20. 21. 22. Clobazam24 23. 24. 25. Clopidogrel27 26. 27. Codeine29 28. Crizotinib30 29. Dapsone31 30. Dasatinib32 31. 32. 33. 34. 35. 36. 37. 38. 39. 40. 41. 42. 43. Desipramine33 Desloratadine and Pseudoephedrine34 Dexlansoprazole (1)35 Dexlansoprazole (2)36 Dextromethorphan and Quinidine37 Diazepam38 Doxepin39 Clomiphene25 Clomipramine26

Therapeutic Area

Biomarker

Oncology

EGFR

Cetuximab (2)18 Cevimeline19 Chlordiazepoxide and Amitriptyline20 Chloroquine21 Citalopram (1)22 Citalopram (2)23

Oncology Dermatology and Dental Psychiatry Antiinfectives Psychiatry Psychiatry Neurology

KRAS CYP2D6 CYP2D6 G6PD CYP2C19 CYP2D6 CYP2C19

Label Sections Pharmacology Indications and Usage, Warnings and Precautions, Description, Clinical Pharmacology, Clinical Studies Indications and Usage, Clinical Pharmacology, Clinical Studies Drug Interactions Precautions Precautions Drug Interactions, Warnings Drug Interactions Clinical Pharmacology, Dosage and Administration, Use in Specific Populations Precautions Drug Interactions Boxed Warning, Dosage and Administration, Warnings and Precautions, Drug Interactions, Clinical Pharmacology Drug Interactions, Clinical Pharmacology Warnings and Precautions, Use in Specific Populations, Clinical Pharmacology Indications and Usage, Warnings and Precautions, Adverse Reactions, Clinical Pharmacology, Clinical Studies Indications and Usage, Precautions, Adverse Reactions, Patient Counseling Information Indications and Usage, Clinical Studies, Patient Counseling Information Drug Interactions Clinical Pharmacology Clinical Pharmacology, Drug Interactions Clinical Pharmacology Clinical Pharmacology, Warnings and Precautions Drug Interactions, Clinical Pharmacology Precautions Precautions, Drug Interactions Clinical Pharmacology Drug Interactions, Clinical Pharmacology Contraindications, Warnings Warnings, Precautions, Clinical Pharmacology Drug Interactions, Clinical Pharmacology

Reproductive and Urologic Rh genotype Psychiatry CYP2D6

Cardiovascular

CYP2C19

Clozapine28

Psychiatry Analgesics

CYP2D6 CYP2D6

Oncology

ALK

Dermatology and Dental

G6PD

Oncology Psychiatry Allergy Gastroenterology Gastroenterology Neurology Psychiatry Psychiatry

Ph Chromosome CYP2D6 CYP2D6 CYP2C19 CYP1A2 CYP2D6 CYP2C19 CYP2D6 CYP2C19 EGFR CYP2C19 DPD CYP2D6 CYP2D6

Drospirenone and Ethinyl Reproductive Estradiol40 Erlotinib41 Esomeprazole42 Fluorouracil43 Fluoxetine44 Fluoxetine and Olanzapine45 Oncology Gastroenterology Dermatology and Dental Psychiatry Psychiatry

Drug 44. 45. 46. 47. 48. 49. 50. 51. 52. Iloperidone54 Flurbiprofen46 Fluvoxamine (1)47 Fluvoxamine (2)48 Fluvoxamine (3)49 Fulvestrant50 Galantamine51 Gefitinib (1)52 Gefitinib (2)53

Therapeutic Area Rheumatology Psychiatry Psychiatry Psychiatry Oncology Neurology Oncology Oncology CYP2C9 CYP2C9

Biomarker

Label Sections Clinical Pharmacology, Special Populations Drug Interactions Drug Interactions Drug Interactions Indications and Usage, Patient Counseling Information Special Populations Drug Interactions Clinical Pharmacology Clinical Pharmacology, Dosage and Administration, Drug Interactions, Specific Populations, Warnings and Precautions Indications and Usage, Dosage and Administration Clinical Pharmacology, Clinical Studies Indications and Usage, Dosage and Administration, Clinical Pharmacology, Clinical Studies Indications and Usage, Dosage and Administration, Clincal Studies Indications and Usage, Dosage and Administration, Clinical Studies Drug Interactions Dosage and Administration, Warnings, Clinical Pharmacology Clinical Pharmacology Indications and Usage, Clinical Pharmacology, Patient Counseling Information Boxed Warning, Indications and Usage Indications and Usage, Warnings and Precautions, Clinical Pharmacology, Clinical Studies, Patient Counseling Information Dosage and Administration, Contraindications, Precautions, Adverse Reactions, Clinical Pharmacology Precautions, Clinical Pharmacology Drug Interactions Drug Interactions Clinical Pharmacology, Special Populations, Precautions, Warnings Drug Interactions Drug Interactions, Clinical Pharmacology Indications and Usage, Patient Counseling Information Warnings and Precautions, Clinical Pharmacology

CYP2C19 CYP2D6 ER receptor CYP2D6 CYP2D6 EGFR

Psychiatry

CYP2D6

53. Imatinib (1)55 54. Imatinib (2)56 55. Imatinib (3)57 56. Imatinib (4)58 57. 58. Irinotecan60 59. 60. Lapatinib62 61. 62. Maraviroc64 63. Mercaptopurine65 64. 65. 66. 67. Mivacurium69 68. 69. 70. 71. Nefazodone70 Nelfinavir71 Nilotinib (1)72 Nilotinib (2)73 Musculoskeletal Psychiatry Antivirals Oncology Oncology Cholinesterase gene CYP2D6 CYP2C19 Ph Chromosome UGT1A1 Oncology TPMT Antivirals CCR5 Lenalidomide63 Oncology Hematology Her2/neu 5q Chromosome Isosorbide and Hydralazine61 Oncology Cardiovascular UGT1A1 NAT1; NAT2 Imipramine59 Oncology Psychiatry FIP1L1-PDGFR CYP2D6 Oncology PDGFR Oncology Ph Chromosome Oncology C-Kit

Metoprolol66 Modafinil (1)67 Modafinil (2)68

Cardiovascular Psychiatry Psychiatry

CYP2D6 CYP2C19 CYP2D6

Drug 72. 73. Panitumumab (1)75 74. 75. 76. 77. 78. 79. Pimozide81 80. Prasugrel82 81. Pravastatin83 82. 83. 84. 85. 86. 87. 88. 89. 90. Propafenone84 Propranolol85 Protriptyline86 Quinidine87 Rabeprazole88 Rasburicase89 Panitumumab (2)76 Pantoprazole77 Paroxetine78 Peginterferon alfa-2b79 Perphenazine80 Nortriptyline74

Therapeutic Area Psychiatry Oncology Oncology Gastroenterology Psychiatry Antivirals Psychiatry Psychiatry

Biomarker CYP2D6 EGFR KRAS CYP2C19 CYP2D6 IL28B CYP2D6 CYP2D6

Label Sections Drug Interactions Indications and Usage, Warnings and Precautions, Clinical Pharmacology, Clinical Studies Indications and Usage, Clinical Pharmacology, Clinical Studies Clinical Pharmacology, Drug Interactions, Special Populations Clinical Pharmacology, Drug Interactions Clinical Pharmacology Clinical Pharmacology, Drug Interactions Warnings, Precautions, Contraindications, Dosage and Administration Use in Specific Populations, Clinical Pharmacology, Clinical Studies Clinical Studies Clinical Pharmacology Precautions, Drug Interactions, Clinical Pharmacology Precautions Precautions Drug Interactions, Clinical Pharmacology Boxed Warning, Contraindications Adverse Reactions, Clinical Pharmacology Drug Interactions, Clinical Pharmacology Indications and Usage, Description, Clinical Pharmacology Indications and Usage, Dosage and Administration, Nutritional Management Indications and Usage, Precautions, Medication Guide Clinical Pharmacology Drug Interactions Dosage and Administration, Warnings, Clinical Pharmacology Dosage and Administration, Precautions, Warnings Precautions, Warnings, Contraindications Clinical Studies Clinical Pharmacology Clinical Pharmacology Clinical Pharmacology, Drug Interactions, Warnings and Precautions Indications and Usage, Clinical

Cardiovascular

CYP2C19 Genotype E2/E2 and Fredrickson Type III dysbetalipoproteinemia CYP2D6 CYP2D6 CYP2D6 CYP2D6 CYP2C19 G6PD NAT1; NAT2 CYP2D6 UCD (NAGS; CPS; ASS; OTC; ASL; ARG) UCD (NAGS; CPS; ASS; OTC; ASL; ARG) ER receptor IL28B CYP2D6 CYP2D6 TPMT CYP2D6 CYP2C19 CYP2D6 CYP2D6

Cardiovascular Cardiovascular Cardiovascular Psychiatry Antiarrhythmics Gastroenterology Oncology

Rifampin, Isoniazid, and Antiinfectives Pyrazinamide90 Risperidone91 Sodium Phenylacetate and Sodium Benzoate92 Psychiatry Gastroenterology

91. Sodium Phenylbutyrate93 Gastroenterology 92. 93. 94. 95. Tetrabenazine97 96. 97. 98. 99. 100. 101. Tolterodine103 102. Tositumomab104 Thioguanine98 Thioridazine99 Ticagrelor100 Timolol101 Tiotropium102 Neurology Oncology Psychiatry Cardiovascular Opththalmology Pulmonary Tamoxifen94 Telaprevir95 Terbinafine96 Oncology Antivirals Antifungals

Reproductive and Urologic CYP2D6 Oncology CD20 antigen

Drug 103. Tramadol and Acetaminophen105 104. Trastuzumab106 105. 106. 107. 108. Vemurafenib110 109. 110. 111. Warfarin (1)113 112. Warfarin (2)114 Tretinoin107 Trimipramine108 Valproic Acid109

Therapeutic Area Analgesics Oncology Dermatology and Dental Psychiatry Psychiatry

Biomarker CYP2D6 Her2/neu PML/RAR CYP2D6 UCD (NAGS; CPS; ASS; OTC; ASL; ARG) BRAF

Label Sections Pharmacology Clinical Pharmacology Indications and Usage, Precautions, Clinical Pharmacology Boxed Warning, Dosage and Administration, Precautions Drug Interactions Contraindications, Precautions, Adverse Reactions Indications and Usage, Warning and Precautions, Clinical Pharmacology, Clinical Studies, Patient Counseling Information Drug Interactions Clinical Pharmacology, Drug Interactions Dosage and Administration, Precautions, Clinical Pharmacology Dosage and Administration, Precautions, Clinical Pharmacology

Oncology

Venlafaxine111 Voriconazole112

Psychiatry Antifungals Hematology

CYP2D6 CYP2C19 CYP2C9

Hematology

VKORC1