Proprieti

i
caracteristi
Nr.
crt.

DCI (denumire generic)

I. Insuline cu aciune rapid (analogi)

1. Soluie injectabil de insulin lispro
2. Soluie injectabil de insulin aspart
3. Soluie injectabil de insulin glulisine

II. Insuline cu aciune scurt

4. Soluie injectabil de insulin uman

5.

Soluie injectabil de insulin uman ADN recombinant

6.

Soluie injectabil de insulin uman regular

III. Insuline cu aciune intermediar

7. Suspensie injectabil de protamin insulin

Debut

Timp pn
la
conc. max.

Timp max.
de aciune

Cartu 3 ml pt. pen

Cartu 3 ml pt.pen
Flacon 10 ml
Dispozitiv preumplut 3 ml
Cartu 3 ml pt. pen

100 UI/ml
100 UI/ml
100 UI/ml
100 UI/ml
100 UI/ml

161600
252000
12000
78000
78000

210080
312000
15600
93000
93000

Flacon 5 ml
Dispozitiv preumplut 3 ml
Cartu 3 ml pt. pen
Flacon 10 ml
Dispozitiv preumplut 3 ml
Cartu 3 ml pt. pen
Flacon 10 ml
Cartu 3 ml pt. pen

100 UI/ml
100 UI/ml
100 UI/ml
100 UI/ml
100 UI/ml
100 UI/ml
100 UI/ml
100 UI/ml

54000
87490
78000
72000
132000
840000
48000
300000

66000
105000
93600
86400
156000
1008000
57600
360000

Flacon 5 ml
Dispozitiv preumplut 3 ml
Cartu 3 ml pt.pen
Dispozitiv preumplut 3 ml
Cartu 3 ml pentru pen
Flacon 10 ml
Cartu 3 ml pt. pen

100 UI/ml
100 UI/ml
100 UI/ml
100 UI/ml
100 UI/ml
100 UI/ml
100 UI/ml

65260
49400
48000
60000
360000
32400
144000

78320
59280
57600
72000
432000
38400
172800

Flacon 10 ml
Dispozitiv preumplut 3 ml
Cartu 3 ml pt. pen
14-20 ore
Dispozitiv preumplut 3 ml
Cartu 3 ml pt. pen
dependent de doza

100 UI/ml
100 UI/ml
100 UI/ml
100 UI/ml
100 UI/ml

60000
180000
240000
300000
150000

78000
240000
312000
390000
185000

30 min.

1-4 ore

7-9 ore

30 min.

1,5-3,5 ore

7-8 ore

0-30 min.

2-4 ore

12 ore

1 or

3-4 ore

11-20 ore

8.

Suspensie injectabil de izofan insulin uman ADN recombinant

1,5 ore

4-12 ore

24 ore

9.

Suspensie injectabil de izofan insulin

1-2 ore

4-10 ore

18-20 ore

platou 24 ore

11. Soluie injectabil de insulin detemir

6-8 ore

Necesar
minim U.T.
pentru 2008

2-5 ore
3-5 ore
6 ore

15 min.
30-70 min.
10-20 min.
1-3 ore
10-20 min. 60-90 min.

IV. Insuline cu aciune lung

10. Soluie injectabil de insulin glargine - analog lent

Forma farmaceutic

Necesar minim U.T.

Conc. pe U.T.
pentru 2007

V. Insuline bifazice
Suspensie injectabil bifazic de izofan insulin 25% insulin dizolvat i
12. 75% protamin insulin

30-60 min.

2-4 ore

12-19 ore

Flacon 5 ml
Dispozitiv preumplut 3 ml
Cartu 3 m pt. penl

100 UI/ml
100 UI/ml
100 UI/ml

90000
141050
131300

108000
169260
157560

Suspensie injectabil bifazic de izofan insulin 50% insulin dizolvat i

13. 50% protamin insulin

30 min.

1,5-4 ore

12-16 ore

Flacon 5 ml
Dispozitiv preumplut 3 ml
Cartu 3 ml pt. pen

100 UI/ml
100 UI/ml
100 UI/ml

0
24000
24000

28800
28800

Suspensie injectabil bifazic de insulin uman ADN recombinant 20%

14. insulin solubil i 80% izofan insulin

30 min.

2-8 ore

24 ore

Cartu 3 m pt. penl

100 UI/ml

12000

19000

Suspensie injectabil bifazic de insulin uman ADN recombinant 30%

15. insulin solubil i 70% izofan insulin

30 min.

2-8 ore

24 ore

Suspensie injectabil bifazic de insulin uman ADN recombinant 40%

16. insulin solubil i 60% izofan insulin

Dispozitiv preumplut 3 ml
Cartu 3 ml pt pen

100 UI/ml
100 UI/ml

202200
1251900

242640
1502280

30 min.

2-8 ore

24 ore

Cartu 3 m pt. penl

100 UI/ml

48000

57600

Suspensie injectabil de insulin aspart bifazic cu eliberare dual 30%

17. insulin aspart i 70% insulin aspart protaminat

10-20 min.

1-4 ore

24 ore

Dispozitiv preumplut 3 ml

100 UI/ml

271700

353200

Suspensie injectabil bifazic de 30% insulin regular i 70% izofan

18. insulin cristalin

30-60 min.

2-12 ore

22 ore

Flacon 10 ml

100 UI/ml

60000

72000

Cartu 3 ml pt pen

100 UI/ml

600000

720000

Suspensie injectabil bifazic de insulin lispro 25% insulin lispro i 75%

19. suspensie de protamin a insulinei lispro
Suspensie injectabil bifazic de insulin lispro 50% insulin lispro i 50%
20. suspensie de protamin a insulinei lispro
VI. Glucagon
21. Glucagon

15 min.

30-70 min.

15 ore

Cartu 3 ml pt. pen

100 UI/ml

156000

202800

15 min.

30-70 min.

15 ore

Cartu 3 ml pt. pen

100 UI/ml

36000

44400

1 mg

12000

18000

iv. 1 min.
im. 5/15 min.

5-20 min.
10-40 min.

Flacon 1 ml

Proprieti i caracteristici
farmacodinamice (conform ANM)

Nr.
crt.

COD ATC

DCI

GRUPA I. Insuline cu aciune rapid (analogi)

1
A10AB04 INSULINUM LISPRO
2
A10AB05 INSULINUM ASPART
3
A10AB06 INSULINUM GLULIZINA
A10AB06 INSULINUM GLULIZINA
A10AB06 INSULINUM GLULIZINA
GRUPA II. Insuline cu aciune scurt
4
A10AB01 INSULINUM UMANE
A10AB01 INSULINUM UMANE
A10AB01 INSULINUM UMANE
5

A10AB01
A10AB01
A10AB01

INSULINUM UMANE
INSULINUM UMANE
INSULINUM UMANE

A10AB01
A10AB01

INSULINUM UMANE
INSULINUM UMANE

FORMA FARMACEUTICA

Soluie injectabil de insulin lispro

Soluie injectabil de insulin aspart
Soluie injectabil de insulin glulisine

Proprieti i
caracteristici
farmacodina
mice
(conform
Timp pn la
ANM)
conc. max.

Forma farmaceutic

Conc. pe
U.T.

CONSUM
2006

NECESAR
MINIM

Necesar U.T. Necesar U.T.

pentru 2007 pentru 2008

Valoare
maxim
estimat (lei)

Timp max.
de aciune

15 min.
10-20 min.
10-20 min.

30-70 min.
1-3 ore
60-90 min.

2-5 ore
3-5 ore
6 ore

Cartu 3 ml pt. pen 2

Cartu 3 ml pt.pen 1
Flacon 10 ml
Dispozitiv preumplut 3 ml
Cartu 3 ml pt. pen 3

100 UI/ml
100 UI/ml
100 UI/ml
100 UI/ml
100 UI/ml

124,315
183,998
0
0
0

62,158
91,999
1,320
8,800
16,500

178,000
277,000
13,200
88,000
165,000

255,000
390,000
19,000
145,000
270,000

Soluie injectabil de insulin uman

30 min.

1-4 ore

7-9 ore

Flacon 5 ml
Dispozitiv preumplut 3 ml
Cartu 3 ml pt. pen 3

100 UI/ml
100 UI/ml
100 UI/ml

35,798
67,211
49,893

17,899
33,606
24,947

60,000
97,000
80,000

Soluie injectabil de insulin uman

ADN recombinant

30 min.

1,5-3,5 ore

7-8 ore

Flacon 10 ml
Dispozitiv preumplut 3 ml
Cartu 3 ml pt. pen 1

100 UI/ml
100 UI/ml
100 UI/ml

50,729
99,284
552,076

25,365
49,642
276,038

Soluie injectabil de insulin uman

regular

0-30 min.

2-4 ore

12 ore

Flacon 10 ml
Cartu 3 ml pt. pen 2

100 UI/ml
100 UI/ml

28,331
211,058

1 or

3-4 ore

11-20 ore

Flacon 5 ml
Dispozitiv preumplut 3 ml
Cartu 3 ml pt.pen 3

100 UI/ml
100 UI/ml
100 UI/ml

Suspensie injectabil de izofan insulin

uman ADN recombinant

1,5 ore

4-12 ore

24 ore

Suspensie injectabil de izofan insulin

1-2 ore

4-10 ore

18-20 ore

Dispozitiv preumplut 3 ml
Cartu 3 ml pentru pen 1
Flacon 10 ml
Cartu 3 ml pt. pen 2

80,000
127,000
114,000

11,331,610
21,877,600
3,676,596
9,120,552
16,495,200
0
0
3,910,480
5,233,088
3,940,528

113,316.10
218,776.00
36,765.96
91,205.52
164,952.00
0.00
0.00
39,104.80
52,330.88
39,405.28

79,000
145,000
924,000

105,000
189,000
1,220,000

6,132,720
8,217,068
38,917,888

61,327.20
82,170.68
389,178.88

14,166
105,529

44,000
330,000

70,000
436,000

4,937,340
12,781,476
0
0

49,373.40
127,814.76
0.00
0.00

50,198
37,767
34,053

25,099
18,884
17,027

72,000
55,000
53,000

95,000
72,000
70,000

4,663,308
2,579,624
2,873,526

46,633.08
25,796.24
28,735.26

100 UI/ml
100 UI/ml
100 UI/ml
100 UI/ml

42,251
254,400
22,562
101,498

21,126
127,200
11,281
50,749

66,000
396,000
36,000
159,000

87,000
523,000
47,000
210,000

3,764,106
16,681,688
3,594,730
6,157,134
0
0

37,641.06
166,816.88
35,947.30
61,571.34
0.00
0.00

Flacon 10 ml
Dispozitiv preumplut 3 ml
Cartu 3 ml pt. pen 3
Dispozitiv preumplut 3 ml
Cartu 3 ml pt. pen 1

100 UI/ml
100 UI/ml
100 UI/ml
100 UI/ml
100 UI/ml

33,442
137,155
184,587
0
0

16,721
68,578
92,294
19,800
27,500

52,800
210,000
280,000
198,000
275,000

90,000
320,000
420,000
303,000
400,000

20,670,300
24,939,680
33,964,000
22,760,430
28,784,700
0
0

206,703.00
249,396.80
339,640.00
227,604.30
287,847.00
0.00
0.00

GRUPA III. Insuline cu aciune intermediar

7

A10AC01
A10AC01
A10AC01

INSULINE UMANE
INSULINE UMANE
INSULINE UMANE

A10AC01
A10AC01
A10AC01
A10AC01

INSULINE UMANE
INSULINE UMANE
INSULINE UMANE
INSULINE UMANE

Suspensie injectabil de protamin

insulin

GRUPAIV. Insuline cu aciune lung

10

11

A10AE04
A10AE04
A10AE04
A10AE05
A10AE05

INSULINUM GLARGINE
INSULINUM GLARGINE
INSULINUM GLARGINE
INSULINUM DETEMIR
INSULINUM DETEMIR

Soluie injectabil de insulin glargine analog lent

platou 24 ore

Soluie injectabil de insulin detemir

6-8 ore
14-20 ore
dependent de doza

GRUPA V. Insuline bifazice

12

A10AD01
A10AD01
A10AD01

INSULINE UMANE
INSULINE UMANE
INSULINE UMANE

13

A10AD01
A10AD01
A10AD01

INSULINE UMANE
INSULINE UMANE
INSULINE UMANE

14

A10AD01

INSULINE UMANE

15

A10AD01

INSULINE UMANE

Garanie de
participare
(lei)

Suspensie injectabil bifazic de izofan

insulin 25% insulin dizolvat i 75%
protamin insulin

30-60 min.

2-4 ore

12-19 ore

Flacon 5 ml
Dispozitiv preumplut 3 ml
Cartu 3 m pt. pen 3

100 UI/ml
100 UI/ml
100 UI/ml

67,947
108,431
101,040

33,974
54,216
50,520

100,000
160,000
145,000

131,000
204,805
195,000

6,452,292
8,522,565
6,906,080

64,522.92
85,225.65
69,060.80

Suspensie injectabil bifazic de izofan

insulin 50% insulin dizolvat i 50%
protamin insulin

30 min.

1,5-4 ore

12-16 ore

Flacon 5 ml
Dispozitiv preumplut 3 ml
Cartu 3 ml pt. pen 3

100 UI/ml
100 UI/ml
100 UI/ml

2,000
12,011
18,747

500
6,006
9,374

5,000
20,000
27,000

8,000
35,000
35,000

351,000
1,284,910
1,259,344

3,510.00
12,849.10
12,593.44

30 min.

2-8 ore

24 ore

Cartu 3 m pt. pen 1

100 UI/ml

3,742

1,871

6,000

9,600

283,172

2,831.72

30 min.

2-8 ore

24 ore

Dispozitiv preumplut 3 ml

100 UI/ml

155,520

77,760

250,000

300,000

13,531,100

135,311.00

Suspensie injectabil bifazic de insulin

uman ADN recombinant 20% insulin
solubil i 80% izofan insulin
Suspensie injectabil bifazic de insulin
uman ADN recombinant 30% insulin
solubil i 70% izofan insulin

Proprieti i caracteristici
farmacodinamice (conform ANM)

Nr.
crt.

COD ATC

A10AD01

DCI

FORMA FARMACEUTICA

Proprieti i
caracteristici
farmacodina
mice
(conform
Timp pn la
ANM)
conc. max.

Suspensie injectabil bifazic de insulin

uman ADN recombinant 40% insulin
solubil i 60% izofan insulin
Suspensie injectabil de insulin aspart
bifazic cu eliberare dual 30% insulin
aspart i 70% insulin aspart
protaminat
Suspensie injectabil bifazic de 30%
insulin regular i 70% izofan insulin
cristalin

NECESAR
MINIM

Necesar U.T. Necesar U.T.

pentru 2007 pentru 2008

Valoare
maxim
estimat (lei)
Cartu 3 ml pt pen 1

100 UI/ml

962,667

481,334

1,380,000

1,820,000

58,086,400

580,864.00

24 ore

Cartu 3 m pt. pen 1

100 UI/ml

21,824

10,912

35,500

60,000

1,733,516

17,335.16

10-20 min.

1-4 ore

24 ore

Dispozitiv preumplut 3 ml

100 UI/ml

208,876

104,438

300,000

430,000

23,944,000

239,440.00

30-60 min.

2-12 ore

22 ore

Flacon 10 ml

100 UI/ml

42,240

21,120

66,000

87,000

6,626,430

66,264.30

Cartu 3 ml pt pen 2

100 UI/ml

386,291

193,146

640,000

872,000

25,229,232

252,292.32

15 ore

Cartu 3 ml pt. pen 2

100 UI/ml

119,771

59,886

172,000

246,000

11,394,680

113,946.80

15 ore

Cartu 3 ml pt. pen 2

100 UI/ml

4,000

40,000

57,000

2,224,986
0
0

22,249.86
0.00
0.00

1 mg

2,180

1,090

12,000

18,000

2,132,100
487,967,180.50

21,321.00
4,879,671.80

17

A10AD05

INSULINUM ASPART

18

A10AD01

INSULINE UMANE

A10AD01

INSULINE UMANE

A10AD04

INSULINUM LISPRO

Suspensie injectabil bifazic de insulin

lispro 25% insulin lispro i 75%
suspensie de protamin a insulinei lispro

15 min.

30-70 min.

INSULINUM LISPRO

Suspensie injectabil bifazic de insulin

lispro 50% insulin lispro i 50%
suspensie de protamin a insulinei lispro

15 min.

30-70 min.

GRUPA VI. Glucagon

21

H04AA01

GLUCAGONUM

Glucagon

Garanie de
participare
(lei)

2-8 ore

INSULINE UMANE

A10AD04

CONSUM
2006

30 min.

A10AD01

20

Conc. pe
U.T.

Timp max.
de aciune

INSULINE UMANE

16

19

Forma farmaceutic

iv. 1 min./ im.

5/15min.

5-20 min./ 1040 min.

Flacon 1 ml

* NOTA - furnizorul insulinelor va pune la dispozitie si sistemele necesare, in cantitatea corespunzatoare, administratrii solutiei/suspensiei injectabile.