Catabolismul hemului

Catabolismul hemului

Biosinteza nucleotidelor purinice

Transformarea nucleotidelor
purinice
O
HN
HC
P

C
N

NH2
C
C

Asp
CH

P
GTP

Furamat
GDP+Pi

Inozin monofosfat
IMP

NAD

NADH+H

O
N

HN

Gln
O

Glu

CH2

N
H

CH2

Adenzin monofosfat
AMP

H2N

CH2

HN

CH2

ATP
ADP+Pi
Guanozin monofosfat
GMP

Xantin monofosfat
XMP

Bz.azotate

CH2

P
OH OH
PRPP

Fosforibozil
transferaza
PPi

CH2 Bz.azotate
O

OH OH
Nucleotid

HN

O
Xantin oxidaza

N
H
H 2O
Hipoxantina

HN
O

2H

N
N
H
H
Xantina

Xantin oxidaza

HN
O

H 2O
2H

N
N
H
H
Ac.uric

Biosinteza nucleotidelor pirimidinice

+

NAD
Dihidroorotat DH

CITOSOL

NH2

Carbamil fosfat
sintetaza

Gln+CO2

NADH+H

O + Glu

P
O
ADP Carbamil fosfat

ATP

HN
O

NH2
HOOC

CH
CH2

NH2

HO

COOH

Aspartat
transcarbamilaza
Pi

HO
H2N
C

O
C

H2N

CH

N
O
H
Ac.carbamil
aspartic

C H2
HN

COOH
O

C H2
CH

N
O
CH2

PPi
COOH

COOH
N
H
Ac.orotic

PRPP
CITOSOL

HN

COOH

N
H
Ac.dihidroorotic
O

HN

O
C

COOH
N
H
Ac.orotic
CITOSOL

CH
N
O
H
Ac.carbamil
aspartic

HN
COOH

H2 O
C H2

Orotat monofosfat
OMP

MITOCONDRIE
CO2

N
O
CH2
O

Uridin monofosfat
UMP

Sinteza celorlalte nucleotide

pirimidinice
UMP

UDP

ATP

UTP

ATP

ADP

ADP
NH2
N

ADP+Pi
ATP
CTP sintetaza
P
UTP
Gln

N
O
CH2
O

Glu
Citidin trifosfat
TMP

O
HN

5 10

N N metilen FH4

N
O
CH2
O

dUridin monofosfat
dUMP

FH4
P

HN

CH3

N
O
CH2
O

dTimidin monofosfat
dUMP

Catabolismul pirimidinelor
NH2
NH3
O

Uracil

N
O

N
H
Citozina

HN

HN
N
H

O
H2O

NADPH+H
NADP

O
H2O

O
HO
C
H2N

HO
C
H2N

N
H
N carbamil Ala
H2O

CH2

NADP

CH3

OH

COOH

CH

NH2
Ac.carbamic

CH2
NH2
Ala

NADPH+H

N
H
Ac.N carbamil
amino izobutiric
H 2O

COOH

N
H

Timina
CH3

CO2+NH3

CH3

CH2
NH2
Ac. amino izobutiric

Succinil CoA