Hidrogeluri pe bază de polimeri

biocompatibili pentru aplicații

biomedicale

MASTERAND: Ing. COJOCARU Crina-Thea

COORDONATORI: Prof. Dr. Ing. Cătălin ZAHARIA

Dr. Anita Laura RADU și Dr. Andrei SÂRBU
(INCDCP – ICECHIM)
 Hidrogeluri

Ce sunt?
Ce sunt?

Polimeri hidrofilici cu structura 3D

Capacitate mare de a retine fluide

Biodegradabile, biocompatibile, caracter non-toxic

Cost de productie ridicat si rezistenta mecanica scazuta
 Hidrogeluri

Ce sunt? Cum?
Cum?

Copolimerizare Radicalica

Polimerizare in suspensie inversa

Polimerizare in miniemulsie inversa

 Hidrogeluri

Ce sunt? Cum? Scop?

Scop?

Biomedical

Cosmetice

Agricultura
Biomedical

Ingineria Pansamente
tesuturilor dermice

Sisteme cu
eliberare
controlata
 Hidrogeluri cu aplicatii in domeniul Biomedical

Monomer Agent de Reticulare Initiator

Polietilenglicol MBA Sistem Redox:
diacrilat N,N'-metilenbisacrilamida • Persulfat de potasiu
MM = 700 g/mol • Metabisulfit de sodiu

Solutie apoasa Incarcare cu medicament

Apa la 37°C 5-Fluorouracil
Grad de Gonflare

173
180
159
20 PEGDA
133
Grad de gonflare, %

160
140

30 PEGDA
120
100
80
60
40
20 40 PEGDA
0
20 30 40

Concentratie de Monomer(PEGDA700), %
Analiza FTIR
-CH -C=O -C-O-H
-OH
(PEG)
Analiza Termogravimetrica
Proba Pierdere masica, %
10 PEGDA700 95.437
20 PEGDA700 99.996
30 PEGDA700 99.585
10 PEGDA700 40 PEGDA700 97.196
100
20 PEGDA700
30 PEGDA700
80 40 PEGDA700
Pierdere masica (%)

60

40

20

0 100 200 300 400 500 600 700

Temperatura (°C)
Analiza TEM – 30% PEGDA
Incarcarea hidrogelurilor cu medicament

96.0

96.0
Eficiența încărcării, %

95.5
95.0
94.5 93.5
94.0
93.5
93.0
92.5
92.0
20 PEGDA700 (1MBA) 30 PEGDA700 (1MBA)
 Eliberarea controlata de principiu activ
0.9
y = 5359.9x + 0.3497

Concentratia cumulativa, mg/mL

2
R =1
0.8
4.0
Absorbanta265nm (u.a.)

0.7
3.0

0.6
30 PEGDA 1%
2.0
MBA
0.5
20 PEGDA 1%
MBA
0.4 1.0

0.3
0.0 2.0x10
-5
4.0x10
-5
6.0x10
-5
8.0x10
-5
1.0x10
-4 0.0
0 300 600 900 1200 1500
Concentratie (mol/L)
Timp, minute

A B
 Concluzii
• Concentratia optima de monomer
• Grad de gonflare
• Sistem cu eliberare controlata
 Bibliografie
[1] Kinam Park, Sang Cheon Lee, Il Keun Kwon. Hydrogels for delivery of bioactive agents: A historical perspective. 2013.
[2] Pieter J. Dijkstra, Jan Feijen, Tina Vermonden, Wim E. Hennink, Sytze J. Buwalda, Kristel W.M. Boere. Hydrogels in a
historical perspective: From simple networks to smart materials. 2014.
[3] Dariush Salari, Adel Reyhanitabar, Azam Rashidzadeh, Ali Olad. On the preparation and swelling properties of
hydrogel nanocomposite based on Sodium alginate-g-Poly(acrylic acid-co-acrylamide)/Clinoptilolite and its application as slow
release fertilizer. 2014.
[4] Ramazan Asmatulu, Aybala Usta. Hydrogels in Various Biomedical Applications. 2015.
[5] D. K. Majumdar K. Pal, A. K. Banthia. Polymeric Hydrogels: Characteri-zation and Biomedical Applications. 2012.
[6] Buddy Ratner, Allan Hoffman, Frederick Schoen, Jack Lemons. Biomaterials Science. An Introduction to Materials in
Medicine. 2nd Edition. AcademicPress, New York, 2004.
[7] Meredith Wiseman, Pierre-Emile Duhamel, Jaan Noolandi, Christopher N., Ta David Myung, Dale Waters and Curtis
W. Frank. Progress in the development of interpenetrating polymer network hydrogels. 2008.
[8] Syed K. H. Gulrez, Saphwan Al-Assaf, and Glyn O. Phillips. Hydrogels: Methods of preparation, characterisation and
applications. Progress in Molecular and Environmental Bioengineering, chapter 5. IntechOpen, Rijeka,2011.
[9] Michael R. Kessler, Vijay Kumar Thakur, Manju Kumari Thakur. Handbookof Composites from Renewable Materials,
Volume 2, Design and Manufacturing. WILEY, 2017.
[10] S. Salmaso, A. Semenzato, S. Bersani, P. Matricardi, F. Rossi, P. Caliceti. Cyclodextrin/PEG based hydrogels for multi-
drug delivery, Int. J. Pharm., vol. 345 (1-2), 2007, p. 42-50
Va multumesc
pentru atentie!