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Scopul studiului
Gasirea unei metode pt distrugerea celulelor maligne Caracteristici : - neinvaziva - viabila pt distrugerea celulelor maligne - specificitate mare - toxicitate redusa
De ce nanoparticule de aur?
Metode
Laborator: GNPs 5nm-metode biochimice, filtrare (filtru de 0.22u). In vitro 4 serii celulare maligne: Hep3B, Panc-1. Serii control doar RF/serii RF+particule GNPs. Studiu case contol/ test t pereche pt.:
Rezultate-citotoxicitatea
Panc-1:
Valoarea P
GNPs + RF
Discutie
GNPs-avantaje
De urmarit pe viitor
Discutie
GNPs-avantaje
De urmarit pe viitor
Discutie
GNPs-avantaje
De urmarit pe viitor
Discutie
GNPs-avantaje
De urmarit pe viitor
Concluzii
Efectul GNPs+RF
Referinte
1. Bilchik AJ, Wood TF, Allegra D, TsioulRamming KP, Morton DL: Cryosurgical ablation and radiofrequency ablation for unresectable hepatic malignant neoplasms: a proposed algorithm. 2. Bleicher RJ, Allegra, Bilchik AJ: Radiofrequency ablation in 447 complex unresectable liver tumors: lessons learned. 3. Curley SA, Marra P, Beaty Early and late complications after radiofrequency ablation of malignant liver tumors in 608 patients. 4. Haemmerich D, Laeseke PF: Thermal tumour ablation: devices, clinical applications and future directions. 5. Gannon CJ, Curley SA: The role of focal liver ablation in the treatment of unresectable primary and secondary malignant liver tumors. 6. Raut CP, Izzo F, Marra P, Ellis LM, Vauthey JN, Cremona F, Curley SA: Significant long-term survival after radiofrequency ablation of unresectable hepatocellular carcinoma in patients with cirrhosis.
Va multumim!