2/26/2014

1
vlrusologle
vlrusologle
lanul cursulul
CaracLere generale
Claslflcarea vlrusurllor
Morfologle sl sLrucLura vlrusurllor
2/26/2014
2
vlrusurlle
SunL agen(l eLlologlcl al unor boll lnfec(loase:
pollomlellLa, ru[eola, rubeola, varlcela, lnfec(la cu Plv.
dlmenslunl mulL mal mlcl (nm) decL bacLerllle => nu poL
fl evlden(laLe la mlcroscopul opLlc, cl doar la cel
elecLronlc.
SLrucLurl acelulare !!!
SLrucLura:
o molecul de acld nuclelc (Aun sau A8n = genom vlral )
proLe[aL de un invell; proLelc (capsld).
vlrusurl
CaracLere generale
vlrusurlle sunL lnerLe meLabollc =>! cresc ;l
! se mulLlpllc pe medll acelulare.
vlrusurlle sunL parazl(l obllgaLorl celularl: se
mulLlpllc doar in lnLerlorul celulelor.
vlrusurlle sunL parazl(l la nlvel geneLlc:
genomul vlral esLe adl(lonaL genomulul
celular.
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3
vlrusurlle
Morfologle sl sLrucLur
evlden(laL prln
mlcroscople elecLronlc
Molecul de acld nuclelc = "#$%!& ()*+&.
invell; proLelc = ,+-.)/0
formaL dln subunlL(l proLelce
ulspus in [urul acldulul nuclelc, dup un Llp de slmeLrle
cublc,
hellcoldal
Aslgur proLec(la acldulul nuclelc vlral.
Acldul nuclelc ;l capslda formeaz !,&#$,+-.)/+ ()*+&0.
2*$3#)# )3#*#, de core, asoclaLe acldulul nuclelc, fr
a;ezare slmeLrlc.
4(#&)6!& ()*+& 7anvelopa vlral sau peplos)
prezenL la unele vlrusurl
89:;5<58:=>: ?5=@;@=59A=
crlLerll
lunc(le de:
acldul nuclelc: A8n sau Aun
slmeLrla capsldel:
cublc
hellcoldal
prezen(a sau absen(a peplosulul:
invellLe
neinvellLe (nude)
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4
Claslflcarea vlrusurllor
l. vlrusurl cu A8n
l.1.SlML18lL Cu8lC nLlnvLLl1L
A. lcornavlrldae
gen LnLerovlrus: rezlsLenL la pP acld
v. pollomlellLlce 1,2, 3,
v. Coxsackle A, 8
v. Lcho: 34 Llpurl
enLerovlrus 68, 69, 70, 71,
gen 8hlnovlrus:
lablle la pP acld
113 seroLlpurl: guLural, bron;lLe,
pneumonll,
gen Peparnavlrus (fosL enLerovlrus
72)
vlrusul hepaLlLel A - PAv
8. Callclvlrldae
PLv (vlrusul hepaLlLel
L)
C. 8eovlrldae
genul 8oLavlrus: grup
A, 8, C: enLerlLe de
larn la copll mlcl,
preven(le prln
vacclnare
Claslflcarea vlrusurllor
l. vlrusurl cu :=B
5C DC ;5E>F=5> 8@G58: 4B?>95F>
A. 1ogavlrldae:
gen 8ublvlrus = v rubeolel - rubeola
8. llavlvlrldae
v. PepaLlLel C (PCv)
C. 8eLrovlrldae:
revers LranscrlpLaz aLa;aL A8n-ulul vlral.
v. lmunodeflclen(el umane: Plv1, Plv2
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5
Claslflcarea vlrusurllor
l. vlrusurl cu :=B
5C HC ;5E>F=5> I>958A5J:9K 4B?>95F>
A. CrLhomyxovlrldae
- vlrusurlle grlpale A, 8, C
8. aramyxovlrldae
gen aramyxovlrus:
vlrusurlle paragrlpale 1,2,
3,4
vlrusul urllan - paroLldlL
epldemlc (orelllon)
gen Morbllllvlrus: vlrusul
ru[eolel
C. 8habdovlrldae
gen Lyssavlrus: vlrusul rablc
u. Coronavlrldae
lnfec(ll resplraLorll
(guLural - 10),
lnfec(ll dlgesLlve lzolaLe
L. Arenavlrldae
produc febre
hemoraglce
sudamerlcane
l. lllovlrldae:
febre hemoraglce
afrlcane, ex. vlrusul
Lbola
C. 8unyavlrldae
Lransmlse prln cpu;e
Claslflcarea vlrusurllor
ll. vlrusurl cu :JB
ll.1.SlML18lL 8@G58: B>4B?>95F>
A. arvovlrldae
gen arvovlrus: v. 8 19: erlLem lnfec(los (a 3-a boal eruLlv a
copllrlel)
8. apovavlrldae
gen apllomavlrus: v. paplloamelor: 70 Llpurl
verucl cuLanaLe, genlLale
paplloame larlnglene (Llp 11, mam - copll)
Pv-cancer de col uLerln (carclnom cervlcal)
C. Adenovlrldae
lnfec(ll resplraLorll, oculare
gasLroenLerlLe (Llp 40-41),
clsLlLe
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Claslflcarea vlrusurllor
llC vl8uSu8l Cu :JB
ll.1.SlML18lL 8@G58: 4B?>95F>
A. PerpeLovldlrae
PerpeLovlrlnae
gen Perpes slmplex: herpes slmplex 1 (PSv1), herpes slmplex 2 (PSv2)
gen varlcella ZosLer: vlrusul varlcelo-zosLerlan (vZv)
PerpeLovlrlnae
gen ClLomegalovlrus - clLomegalovlrus (CMv):clLomegalla cu lncluzll
PerpeLovlrlnae
vlrusul LbsLeln 8aar
mononucleoz lnfec(loas
llmfom 8urklLL, carclnom nazofarlnglan
PP6: LxanLem sublLum, roseola lnfanLum
adul(l: sd mononucleozo - llke, pneumonll, hepaLlLe la lmunodeprlma(l
8. PLAunAvl8luAL
P8v - vlrusul hepaLlLel 8
Claslflcarea vlrusurllor
llC vlrusurl cu :JB
ll.2.SlML18lL I>958A5J:9K
neinvellLeL 8acLerlofagl
lnvellLe
oxvlrldaeL vlrusul varlolel 7#*+/),+30MMN,