Nefropatia lupic

Ciclofosfamida contribuie la inducerea remisiunii i stabilizarea funciei renale

lei G.G., Austin H.A., Crane M. et al. 22. Combination therapy with pulse cyclophosphamide
plus pulse methylprednisolone improves long-termrenal outcome without adding toxicity in
patients with lupus nephritis. Ann Intern Med 2001; 135: 248-57

Eficiena sa este dependentde doza cumulativ, dar administrarea oral (1-3

mg/kgcorp/24 ore) se asociaz cu multiple efecte adverse (23)
Mok C.C., Ying K.Y., Ng W.L. et al. 23. Long-term outcome of diffuse proliferative
glomerulonephritis treated with cyclophosphamide. Am J Med
2006; 119: e25-e33