Documente Academic
Documente Profesional
Documente Cultură
2,
2005
_____________________________________________________________________
ABSTRACT: Myocarditis with abdominal clinics: a fatal evolution. Myocarditis is defined
clinically as inflammation of the heart muscle. The term of myocarditis was initially used to describe diseases
of the heart muscle not associated with valvular abnormalities. Although the cause of myocarditis in any given
patients often remain unknown, a large variety of inflammations, systemic diseases, drugs and toxins have been
associated with the development of this disease. Thus the diagnosis of myocarditis is often challenging to make.
The myocardial process is likely cause of abdominal pain.
Authors present a women case (34-years) with severe abdominal pain initially considered acute
cholecystitis. Unfortunately after abdominal surgery was performed the patient died. Histopathological
examination of the heart established a severe myocarditis with cytolysis.
KEY WORDS: myocarditis, severe abdominal pain, death
91
Hecser L. et al. Myocarditis with abdominal symptomatology: fatal
evolution
Prezentare de caz
Numita B.E. de 34 ani, s-a internat ntr-un spital la data de 30.07.2003, prezentnd o
starea general alterat, dureri abdominale intense n bar, hipotensiune arterial, greuri,
oprirea tranzitului intestinal, paloare tegumentar, cianoza extremitilor.
92
Romanian Journal of Legal Medicine Vol. XIII, nr. 2,
2005
Fig. 2. Miocardit difuz: infiltrat leucocitar intramiocardic cu edem. Col. HE x100 (Hpt.8880/2003)
Discuii
93
Hecser L. et al. Myocarditis with abdominal symptomatology: fatal
evolution
94
Romanian Journal of Legal Medicine Vol. XIII, nr. 2,
2005
95
Hecser L. et al. Myocarditis with abdominal symptomatology: fatal
evolution
96
Romanian Journal of Legal Medicine Vol. XIII, nr. 2,
2005
Cazul prezentat de noi a avut un debut neobinuit, care a implicat probleme majore de
diagnostic, i atitudini terapeutice n sensul simptomatologiei. Evoluia a fost fudroiant,
nefavorabil, cu decesul bolnavei.
Simptomatologia abdominal (digestiv?) polimorf, de intensitate deosebit, se
consemneaz, totui, rar [18,27].
Bibliografie
1. Archard LC, Bowles NE, Cunningham L, et al. Molecular probes for detection of persisting
enterovirus infection of human heart and their prognostic value. Eur Heart J 1991; 12 (suppl.D):56-59.
2. Aretz HT, Billingham ME, Edwards WD, et al. Myocarditis: a histopathologic definition and
classification. Am J Cardiovasc Pathol 1987; 1:3-14.
3. Claydon SM. Myocarditis as an incidental finding in young men dying from unnatural causes. Med
Sci Law 1989; 29:55-58.
4. Caforio ALP, Goldman JH, Baig MK, et al. Cardiac autoantibodies in dilated cardiomyopathy become
undetectable with disease progression. Heart 1997; 77:62-67.
5. Coxsackie B5 virus infections during 1965: a report to the director of the Public Health Laboratory
Service from various laboratories in the United Kingdom. Br Med J 1967; 4:575-577.
6. Davies MJ, Ward DE. How can myocarditis be diagnosed and should be treated? Br Heart J 1992;
68:346-347.
7. Drory Y, Turetz Y, Hiss Y, et al. Sudden unexpected death in persons less 40 years of age. Am J Cardiol
1991; 68:1388-1392.
8. Feldman AM, McNamara D. Myocarditis. N Engl J Med 2000; 343:1388-1398.
9. Fenoglio JJ Jr, Ursell PC, Kellogg CF, et al. Diagnosis and classification of myocarditis by
endomyocardial biopsy. N Engl J Med 1983; 308:12-18.
10. Friedrich MG, Strohm O, Schulz-Menger J, et al. Contrast media-enhanced magnetic resonance
imaging visualizes myocardial changes in the course of viral myocarditis. Circulation 1998; 97:1802-
1809.
11. Jin O, Sole MJ, Butany JW, et al. Detection of enterovirus RNA in myocardial biopsies from patients
with myocarditis and cardiomyopathy using gene amplification by polymerase chain reaction.
Circulation 1990; 82:8-16.
12. Jones SSR, Herskowitz A, Hutchins GM, Baughman KI. Effects of immunosuppressive therapy in
biopsy-proved myocarditis and borderline myocarditis on left ventricular function. Am J Cardiol 1991;
68:370-376.
13. Kawai C. From myocarditis to cardiomyopathy: mechanism of inflammation and cell death: learning
from the past for the future. Circulatiopn 1999; 99:1091-1100.
14. Kibrick S, Benerschke K. Severe generalized disease (encaphalohepatomyocarditis) occuring in the
newborn beriod and due to infection with Coxsackie virus B: evidence of intrauterine infection with
this agent. Pediatrics 1958; 22:857-874.
15. Kuhl U, Lauer B, Souvatzoglu M, et al. Antimyosin scintigraphy and immunohistologic analysis of
endomyocardial biopsy in patients with clinically suspected myocarditis evidence of myocardial cell
damage and inflammation in the absence of histologic sign of myocarditis. J Am Coll Cardiol 1998;
32:1371-1376.
16. Lauer B, Niederau C, Kuhl U, et al. Cardiac troponin T in patients with clinically suspected
myocarditis. J Am Coll Cardiol 1997; 30:1354-1359.
17. Leeper NJ, Wener LS, Dhaliwal G, et al. On surprise after another. N Engl J Med 2005; 352:1474-
1479.
18. Lerner AM. An experimental approach to virus myocarditis. Prog Med Virol 1965; 7:97-115.
19. Li Y, Bourlet T, Andreoletti L, et al. Enteroviral capsid protein VP1 is present in myocardial tissues
from some patients with myocarditis or dilated cardiomyopathy. Circulation 2000; 101:231-234.
20. Lieback E, Hardouin I, Meyer R, et al. Clinical value of echocardiographic tissue characterization in
the diagnosis of myocarditis. Eur Heart J 1996; 17:135-142.
21. Lieberman EB, Hutchins GM, Herskowitz A, et al. Clinicopathologic description of myocarditis. J Am
Coll Cardiol 1991; 18:1617-1626.
22. Liu P, Martion T, Opavsky MA, Penninger J. Viral myocarditis balance between viral infection and
immune response. Can J Cardiol 1996; 12:935-943.
97
Hecser L. et al. Myocarditis with abdominal symptomatology: fatal
evolution
23. Mason W, OConnell JB, Herskowitz A, et al. A clinical trial of immunosupressive therapy for
myocarditis. N Engl J Med 1995; 333:269-275.
24. McCaffrey FM, Braden DS, Strong WB. Sudden cardiac death in young athlets: a review. Am J Dis
Child 1991; 145:177-183.
25. McCarthy RE III, Bochmer JP, Hruban RH, et al. Long-term outcome of fulminant myocarditis as
compared with acute (nonfulminant) myocarditis. N Engl J Med 2000; 342:690-695.
26. McNamara DM, Rosenblum WD, Janosko KM, et al. Intravenous immune globulin in the therapy of
myocarditis and acute cardiomyopathy. Circulation 1997; 95:2476-2478.
27. Oka K, Oohira K, Yatabe Y, et al. Fulminant myocarditis demonstring uncommon morphology a
report of two autopsy cases. Virchows Arch 2005; 446:259-264.
28. Phillips M, Robinowitz M, Higgins JR, et al. Sudden cardiac death in Air Force recruits: a 20-year
review. JAMA 1986: 256:2696-2699.
29. Saphir O. Myocarditis: a general review, with an analysis of two hundred and forty cases. Arch Pathol
1941; 32:1000-1051.
30. Shanes JG, Gahli J, Billingham ME, et al. Interobserver variability in the pathologic interpretation of
endomyocardial biopsy results. Circulation 1987; 75:401-405.
31. Smith SC, Landerson JH, Mason JW, Jaffe AS. Elevation of cardiac troponin I associated with
myocarditis: experimental and clinical correlates. Circulation 1997; 95:163-168.
32. Smith WG. Adult heart disease due to Coxsackie virus group B. Br Heart J 1966; 28:204-220.
33. Wesslen L, Pahlson C, Lindquist O, et al. An increase in sudden unexpected cardiac death among
young Swedish orienteers during 1979-1992. Eur Heart J 1996; 17:902-910.
34. Wojnicz R, Nowalany-Kozielska E, Wodnieczki J, et al. Immunohistological diagnosis of myocarditis:
potential role of sarcolemmal induction of the MHC and ICAM-I in the detection of autoimmune
mediated myocyte injury. Eur Heart J 1998; 19:1564-1572.
35. Yasuda T, Palacios IF, Dee GW, et al. Indium 111-monoclonal antibody imaging in the diagnosis of
acute myocarditis. Circulation 1987; 76:306-311.
98