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UNIVERSITATEA DE

MEDICIN I FARMACIE
GR.T.POPA IAI
FACULTATEA DE MEDICIN GENERAL
ANUL I
SERIA A , GRUPA 8

NICUOR MDLINA

PROTEINELE G I ROLUL LOR N


TRANSDUCIA SEMNALELOR
BIOLOGICE

[1]

CUPRINS

Biofizica n ansamblul tiinelor biologice.........................................................................4


Proteinele.....................................................................................................................................4
Structur general............................................................................................................................4
Sintez chimic................................................................................................................................5
Structur primar.............................................................................................................................5
Structur secundar.........................................................................................................................7
Structur teriar..............................................................................................................................9
Structur cuaternar.......................................................................................................................10

Proteine de cuplaj....................................................................................................................12
Proteine G oligomerice..................................................................................................................12

Structura micilor proteine monomerice G


i interaciunea acestora cu membrana
plasmatic..................................................................................................................................17
Interaciunile proteic-lipidice ale
celulelor heterometrice...........................................................................................................17

BIBLIOGRAFIE

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Bucureti: Medical, 2006
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in milligram amounts for research to multi-tons quantities for drugs of the
future". Current Pharmaceutical Biotechnology 5 (1): 2943. PMID
14965208
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ligation: chasing a protein's tail". Current Opinions in Chemical Biology 9
(6): 56169. PMID 16226484
6. Kent SB. (2009). "Total chemical synthesis of proteins". Chemical Society
Reviews 38 (2): 33851.. PMID 19169452
7. http://ro.wikipedia.org/wiki/Fi%C5%9Fier:InsulinMonomer.jpg
8. http://ro.wikipedia.org/wiki/Proteine
9. http://ro.wikipedia.org/wiki/Fi%C5%9Fier:ProteinStructures.png
10.http://ro.wikipedia.org/wiki/Fi%C5%9Fier:Alfa_helix.PNG
11.http://ro.wikipedia.org/wiki/Fi%C5%9Fier:Myoglobin.png
12.http://ro.wikipedia.org/wiki/Fi%C5%9Fier:Hemoglobin.jpg
13.http://www.referat.ro/referate/Proteine_de_cuplaj_si_rolul_lor_in_transducti
a_semnalului_biologic_09fc2.html
14.http://www.scq.ubc.ca/wp-content/uploads/2006/07/gpsignaling.jpg
15.O.Vgler, Juana.M.Barcel, Catalina Ribas, P.V.Escrib. Membrane
interactions of G proteins and other related proteins; ScienceDirect
1778(2008): 1640-1652.