timp (ore) conc doza(mg) ln C

0 100 100 4.60517

2 80.25 4.385147
4 64.4 4.165114
6 51.69 3.945264
6 151.69 100 5.021839
8 121.73 4.801805
10 97.69 4.581799
12 78.4 4.361824
12 178.4 100 5.184028
14 143.17 4.964033
18 92.21 4.524069
24 47.66 3.864092
36 12.73 2.543961
48 3.4 1.223775

Conc=f(t)
200
180
160
140
120
100
80
60
40
20
0
0 10 20 30 40 50
 Kel int t1/2
0.11 6.5044 6.301338

4
f(x) = − 0.11001321000202 x + 6.50441866536006
Column J
3
elim
Linear (elim)
2

0
Conc=f(t) 0 10 20 30 40 50 60

Column H

30 40 50 60
1866536006
Column J
elim
Linear (elim)
 timp
0.25
0.5
0.75
1
perioada
de 1.5
distributie 2
4
6
8
10
pseudoec 12
hilibru 18

2.5

2 f(x) = − 0.598528024209146 x +

1.5

1
f(x) = − 0
0.5

0
0 2 4 6 8 10 12 1

model bicompartimentat , in acest caaz avem 3 procese kinetice:

compartiment central - compartimanet periferic -V12

compartiment periferic- compartiment central V21
constanta de eliminare Kel

perioada de distributie , concentratia de sm in cc este mare deci si viteza de eliminare va fi mare .

in cp concentratia creste iar V12>21 pana cand viteza celor 2 procese se egaleaza si se instaleaza procesu
Procesul de pseudoechilibru ramane pana la eliminarea completa a substantei medicamentoase

Perioada de pseidoechilibru
V12<V21 atunci cp devine rezervor pentru comparitmentul central
conc din cc se elimina mai rapid decat cea din cp , datorita Kel

procese de desfasoara in pararele in acelasi timp

 conc ln C Beta int (ln B) B ln C' C' C-C'
12.8 2.549445 0.0391 1.3462 3.842795 1.336425 3.805415 8.994585
11.6 2.451005 1.32665 3.768398 7.831602
10.4 2.341806 1.316875 3.731741 6.668259
9.5 2.251292
7.9 2.066863
6.8 1.916923 Alfa int (lnA) A
4.2 1.435085 0.5985 2.35 10.48557
3.3 1.193922
2.9 1.064711
2.6 0.955511 t1/2= 17.72755 A>B si alfa> beta => etapa de distributie se va final
2.4 0.875469
1.9 0.641854

f(x) = − 0.598528024209146 x + 2.34998020121901

Column L
pseudoechi
Linear (pseudoechi)
acumulare
Linear (acumulare )
f(x) = − 0.0391445672430427 x + 1.34620558609181

2 4 6 8 10 12 14 16 18 20

e eliminare va fi mare .
galeaza si se instaleaza procesul de pseudoechilibru
ntei medicamentoase
 ln(C-C')
2.196623
2.058167
1.897359

etapa de distributie se va finaliza inaintea etapei de pseudoechilibru

D=200
timp conc doza ln C int Kel t1/2 lnC'
60 293.4 200 5.681537 8.9776 0.0467 14.84255 6.1756
62 343.3 5.838605 6.0822
64 353.4 5.867601 5.9888
66 343.2 5.838313
68 323.4 5.77889
70 299.7 5.702782 Ka= 0.3538
75 239.4 5.478136
80 187.8 5.235378

6
f(x) = − 0.0467404407548455 x + 8.97763150135363
5 f(x) = − 0.353783046839102 x + 26.4687981008838
Column N
4
elim
Linear (elim)
3
absorbtie
Linear (absorbtie)
2

0
55 60 65 70 75 80 85
C' C'-c ln C'-C
480.8715 187.4715 5.233627
437.9917 94.69172 4.550627
398.9356 45.5356 3.818494
 D= 150mg

timp conc Sm
0 100
1 90.48
2 81.87
3 74.08
4 67.03
5 60.65
6 54.88
8 44.93
10 36.79
12 30.12
18 16.53
24 9.07
36 2.73
48 0.82

120

100

80

60 sm
metabolit
40

20

0
0 10 20 30 40 50 60
 Kel int
0.1001 4.6055
conc m ln C (SM) ln C (m) ln C' (M) c' C'-c ln c-c
0 4.60517 Err:502 4.1942 66.30067 66.30067 4.1942
15.63 4.505129 2.749192 4.0944 60.00333 44.37333 3.792639
24.63 4.405133 3.203965 3.9946 54.30411 29.67411 3.390275
29.31 4.305146 3.377929
31.23 4.20514 3.441379
31.41 4.10512 3.447126
30.54 4.005149 3.419037
27.24 3.805106 3.304686
23.3 3.605226 3.148453 Kum = 0.402
19.53 3.405189 2.971952
10.97 2.805177 2.395164 t1/2 6.924547
6.04 2.204972 1.798404
1.82 1.004302 0.598837
0.55 -0.198451 -0.597837

f(x) = − 0.100055797292205 x + 4.60552737807025

4 f(x) = − 0.401962447699173 x + 4.19433365964239
Column L

3 Linear (Column L)
metabolit
sm
metabolit 2 elim met
Linear (elim met )
f(x) = − 0.0998433755292643 x + 4.19416268981345
1 elim met
Linear (elim met )
0
0 10 20 30 40 50 60
60 -1
 D=

120

100

80

60

40

20

0
0 10 20 30
 250mg caz I Kum<Km metavolitul se elimina mai lent decat sm prim adm iv

timp conc sm conc m ln C sm ln C (M)

0 108.4 0 4.685828 Err:502 Km 0.0566
1 98.08 19.81 4.585783 2.986187 int 5.4242
2 88.75 36.22 4.485823 3.589611
3 80.3 49.66 4.38577 3.9052
4 72.66 60.52 4.285791 4.102974 Kel 0.1
5 65.75 69.15 4.18586 4.236278 int 4.6861
6 59.49 75.85 4.085808 4.328758 t1/2 6.931472
8 48.71 84.51 3.885884 4.43687
10 39.88 88.29 3.685875 4.480627
12 32.65 88.56 3.485845 4.48368 5
18 17.92 77.65 2.885917 4.352212 f(x) = − 0.100038112123967 x + 4.68607323770821
24 9.83 60.58 2.285439 4.103965 4 f(x) = − 0.0566140355515278 x + 5.4241905
36 2.96 31.23 1.085189 3.441379
48 0.89 14.38 -0.116534 2.665838 3

0
0 10 20 30 40 50 60

-1
Column L
metabolit

10 20 30 40 50 60
67 x + 4.68607323770821
566140355515278 x + 5.42419058956855

Column N
Linear (Column N)
metab
elim metab
Linear (elim metab )

40 50 60
D 5ml/min
Conc sol 10mg/ml

timp
0
1

perioada de
acumulare
6
12
24
48
72
78

post-perfuzare
84
90
96
99

5 ml……….1 min
x 72min

x= 360

10mg 1ml
x 360ml
x= 3600
x
x=
in 72 min

conc ln c kel t1/2 tss

0 Err:502 0.07 9.902103 6.66*t1/2 65.84898 min
8.05 2.085672
40.83 3.709417 D* 300 mg
67.65 4.214347
96.86 4.573267
114.91 4.744149
118.28 4.773055 V 6000ml
77.71 4.352984 ko 50mg/min
51.06 3.933001
33.55 3.513037
22.04 3.092859
17.87 2.883123

ln C

ml 6

5
Column L
4 elim
f(x) = − 0.06999842506347 x + 9.81285985927687
Linear (elim)
mg in 72 min 3
1min
50 mg/min 2
pt doza de atac 1

0
0 20 40 60 80 100 120
 conc
140

120

100

80 Column K

60

40

20

Column L 0
elim 0 20 40 60 80 100 120
985927687
Linear (elim)
 timp (ore)
0
2
4
7.3
8
10
12
15
24

60

50

40

30

20

10

0
0 5 10 15 20 25
 volum U
conc urina (ml) Q Qc Q0-Qc ln(Q0-Qc
0 0 0 0 50 3.912023
186.34 85 15.8389 15.8389 34.1611 3.531088
55.52 97 5.38544 21.22434 28.77566 3.35953
146.07 112 16.35984 37.58418 12.41582 2.518971
10.98 142 1.55916 39.14334 10.85666 2.384779
14.14 245 3.4643 42.60764 7.39236 2.000447
18.8 126 2.3688 44.97644 5.02356 1.614139
10.36 215 2.2274 47.20384 2.79616 1.028247
17.98 132 2.37336 49.5772 0.4228 -0.860856

Q=C*V

Column N
Polynomial (Column N)

10 15 20 25 30