Catabolismul hemului

Catabolismul hemului

Biosinteza nucleotidelor purinice

Transformarea nucleotidelor purinice

O HN HC P C N C C N CH N

NH 2
Asp

N N P CH2

N N

CH2

GTP

Furamat GDP+Pi
NAD
+ +

Inozin monofosfat IM P

Ade nzin monofosfat AM P

O N N H P CH2
O

NADH+H

O HN H2N P N CH2 N

HN

Gln Glu
O

ATP ADP+Pi
Guanozin monofosfat GM P
Xantin monofosfat XM P

CH2

Bz.azotate P P

CH2 Bz.azotate
O

Fosforibozil transferaza PPi OHOH Nucleotid

OHOH PRPP

O HN N N Xantin oxidaza HN O 2H

O N Xantin oxidaza H2O 2H HN

O N O

N H H2O Hipoxantina

N N H H Xantina

N N H H Ac.uric

Biosinteza nucleotidelor pirimidinice

+

CITOSOL

NAD Dihidroorotat DH
+

NH 2 C O + Glu

NADH+H

Gln+CO2 ATP

Carbamil fosfat sintetaza

O HN O COOH N H Ac.orotic
CITOSOL

P O ADP Carbamil fosfat

NH 2

HOOC

CH CH 2 COOH

NH 2 C O O P

HO H2N C

O C C H2 COOH
O HN PPi COOH

O HN O COOH N H Ac.orotic

Aspartat transcarbamilaza Pi

CH N O H Ac.carbamil aspartic O HN C C H2 CH

HO H2N C

O C C H2 COOH

H2O

PRPP CITOSOL HN O

N O CH2
O

CH N O H Ac.carbamil aspartic

N H Ac.dihidroorotic O
M ITOCONDRIE

COOH
Orotat monofosfat OM P P

N O CH2
O

CO2

Uridin monofosfat UM P

Sinteza celorlalte nucleotide pirimidinice

UM P ATP UDP ADP ATP UTP ADP
NH 2 N ADP+Pi ATP CTP sintetaza P UTP Gln Glu Citidin trifosfat TM P N O CH2
O

O HN

N N metilen FH4 HN FH4 P N O CH2

O

5 10

O CH3

N O CH2
O

dUridin monofosfat dUM P

dTimidin monofosfat dUM P

Catabolismul pirimidinelor
NH 2 NH 3 O O N N H Citozina HN N H
+

Uracil HN O H2O

Timina CH3

NADPH+H NADP
+

O H2O

N H

NADPH+H NADP CH3

+

O HO C H2N

O HO C H2N O

N H N carbamil Ala H2O O

N H Ac.N carbamil amino izobutiric H2O COOH CH CH2 NH 2 Ac. amino izobutiric CO2+NH3 Succinil CoA CH3

COOH CH2 CH2 NH 2 Ala

OH

NH 2 Ac.carbamic