Hepotite

Eenerolitdfi ' Hepatitele virole suntbolispecific

umone. . Sunt qenerotede virusurile hepofiiice ccre opo(in unor fomilii diferite' Au in conun tr.opismul pcntru cclulo hcpotlcd.
D...dhFbFha 96ftrosr'br.gh

Virusologie speciold

. Estc produd & vhrEll h.pqliiic A (HAV) corle focc iortc din fonilic Plcorravlddc, gcrul Entaovfttr. Ealr. qn vi rs /|ll.l cu colsidil ico$Gdricd nernv"lopct Si d.G 27 nrn. . E3te ezisteil lo tanpcmlrl1o d" 6OoC, ctar, do. 6tc disfnFln .Atcvd nlinufde t"ilDqtdtlr.d de l00oc. de fof|lpl t/,tooo, dupdo.xfrirrlt!. d. 3 h lo 37oC, sdl de clor octiv 0,1%tng,iinp d 30 triI R.Eanqrd da tinE A Estc rctl!.zantqt & bolrbvii icirici Jau dfcfeiici.

Heporfito virold A

virtsul hepotitic A (HAV)

Hepotito virold A
Calca d" tronslnitr." . Este fh spcialf.col-oraltr, direct scu indirect (prin intemrdiul qlitnentelor squo apei contanimte). . Acosli bool6 s noi poot" tronsmit" prin: > sqlivd, > conlqct 3exuolorol souoncl 5i prin ! s64c Srrperioada de viranie).

Hepoti?ovirold A
Pcrioodode incubaticncdia . Estede 3-4 sdptd]nani, perioado de contooiozilote ?nceoe cu 2-3 sdptdir6ni inainte dL periooda icfericd !i sementine lhcd o sbptdm6nd icferului. dupd disparilia R.c"ptivitoteo . Eslegenerold iar imunitotelspcificd estesolidd si durabild.

. PrirElp.hl onrigEr .5t A9 HA. , Antir.rii cof.sF EIio.i - onti-Hl I9S qi - .nfi -Hl &ll. . Virtl3rl ii oniigeicle vimle se pot dccek di.t > moi.riil. fcd. .xdmimte 9ri. irunoelcironicr6copie;

Hepotito virold A

Hepatito virold A
. H.rdtiiq , e D@fe manifsro sub ndi r > rftiqt hctici (ohicrricd), nci olcs 16copii. > Ictldcn .! rimgton. r5pa.ili.e: oaorcxie, detni., pruril, grclura,vdr.dturi, > Fuln{nartit, foarfc ror, cu ndnifest&i nurclogicedrdcteristica ihifaciehl.i

h.Doticd, t.hnic' de > ih h.Ddto.lt D|"rn b'o9sie imunifluores.ind. J

(''mPon:ei 1 'hrerdr 'o p.in >-lliRN-ulvimldn --' Drodus.l.Dotoloqice "ffiftfip' :Hl .-**
d\ftgflci d biologd noL.uld.d (PcRetc.).

H"pstito virold B
Esteproduside HBy coreopo4irefonili
rhFdmvhido., genulft hohcpddtvlrus. . E re un virur lDN, porrlcllo bon., .sir sfzric dr un diomefru d.42 nn..u uh cnru clectromdens & ?8 n|n coresD0nrtrlorrucl.ocopridei 9i oE . P.rriculele Ddnesunt inf.lioo3. Si lor ln s.. s.mhifi.d xif.nb .vid.nti.u

Hepoiito viroltr I
5trxiu.6 arfigpnicd

>,(9 dc a'+mfa!6 HS3

. Constrtiri? fnvehsul extrn dl HBVsi dr o siracluri.ohplaxtr lipoqlicoprof crca.

. Am.lh sanclc bolmvrlor dud 4-6 sdDrlhAnid;1. infatrc.fiEini.d. d.b{rul cli-hic dlhepolilei dupd 3lunid.lo $idispor
. Anri@rDii ofi-AqHgs dDarln conlol.sicnd si d!:anti lor rr!flficn vindt@6 bolii,-qpqr 9i ln u.n6 vqccindtii

i l

Hepotito virdld B structur.i ar|'igei|ic.

aAoH85 fudlcctor inDoriant d" boold in a|. D.in:inunodifuzia tontrsihunlectnof oiezd, hiex HAP, oglurinqrn, ELISA,RIA, che|nilumihiscnt4 prin DAoHBe se decelcozd ?nsAnqe

Strucluro ontignicd

RrA. H:rsA.

oAgH& s. irolcozd nunoi p. dc tlaut h.pctic. -jtlpofotcl.

Hepotito virold B
ar& & ni.di.. @r'dl frl d iaf..1' @'n o kE!' 'tui@ ' Hrv ..fqr.'b,kr dM l6ig.. rdvd $'Ei. o ndbdd r*t'.tustlri. iM turd. b,obri4 dtift o relr. h.h6*!.la * i'frMc.6|!16l d 5r4i & didtotu hoftw|n .u tsftE.i

VirusulhepatiteiC (HVC)
(^RN) oDqrtin6nd ' Esreun nbovrrqs oauhri H.DdcM'rs. fcn,lio Flcviti.ldd!..ri codsidli icosodricd.oivloDdt. . HVC prcduc. h.pdfto viEld d. tlp C . Ir.{bolio durdzdfitue ?-6 sd9l&nAni, tmnsrnit.r! este Drdominont oorenfclold- cl mdi fre.ven+ Fodtmnsfuziomld 9i posl tmnspldnt dc . Tmdnitrad bc dla sexudlll 3e Ddreci qr loc lo pe.siE.ele.u pdrtnari iultipli.

o Edidla, enld a sldq Dorni$ Ftu rsHBr/rqH0. d aedctsrtuEh. rdi*hb 4 6'ild

HVC

Virusul hepotitci C (VHC)

. r|| i4ird@ @rilo. snr cirur@ri4 si dd;rcsricdr rdd'v ln +ddrl & .rrcrd dr . 804 .fin @d fe h.Briri ffia.n, 204 .ituzd id 3% h.et@.ircri'. . Ac!$ .6 rip d. nt In$Ir e & e R h.Parirn .nr. p@r. fifiqir tdE i
rbd,fic&i imumloqia plri d.pu|Er ihuE ih birtui si oRE 3i .eilid rhh. 6 !i! efw^,loi.J.ii. ir!' P6t. 3n @.d * .*dft -

.ompler.ld d.; t@ulit . n '$mrcidli t ;d

'

cfr@lobuliMio hi,td 4t r.i..h f6.lmro' @iE

Picor ovirrrsu . 6en diiAli

Picomvirus

. Sunt virus1rri ARN de dihensiqhi|nici, cupdnd nutnrogiogeflli Potogni pnrru oome 9r dnrmdle. . Afedezd troclul digstiv.reipirdlor 9i uneorisistemulnen os,?hsolilesou ,l nu de exonlene. . Suni lorticule sferice sducu un contur ,, av6nddinrensioni de 24-30 ii hexodonol=::'":::::,

6enulEnterovinrs
. 5e incodreozd specii urlnd'tooael potogene om: Pentru >v, polio|nieliiei; >v. Echo.

V. poliomi"litic
. vin*l pdiroplrto drn orgdii ' vinnl inlioldrit'fuk ,idj.'itfrfli''rie|I.ih|.rr' F dL .rfdigt,{ lin

i'e. $ tui f.dkxrt 'biidDf irhL * f.4 E ek I'hfd.n u.ado ' DisiEa cl'i'e riettw rich . rM'nt* f.d*rb iif4ld or dr r li inloi,tu o'd* k tcht (nndud, db). 4libr ih er nod'u. d iMid

Enoi|e'dor.lid *hflruiffi

Eifthrt

V. polionielitic
lkrat|tbi t|.iaos s! to.. !. Irf..J.rra col. s.nguin6. io propogorcolh Fsirt'rrile Derif.rici. o dotd introt ln cdil n.I!.i, progr.sid ac6tuia ru hai Poote fi oPriid. sirt iNlul Fo.tu ll f.vorien{i oi iif.4l.l ||.er r,lt: ronsrL.tonio-inreMt'i chiru.grc.b,inJ.liiqi rmundri$nc dotorc't l.drii f.rninctiilor nr@s, srr$uliri, obor@h fizid, s6rcin6 9i v&sto.

V..poliomielitic

+ A. Polidi.lfta dditid ler.li:i! infont'Kl cmtu d dt.trad! v&trt dd * M'l6tI hlhoi lo o.l'1 7* diitt. indiviriiinfatuti d t 1- ldm cNni - Flldnr.lirr D@llrld rCmltr, d.tuhira ri b.oh tl'Elu.dih. r-rE 6otraBr? d. 3-14 ih, bo.h .wlu6'd in ddln . D.hur@da f.trd.'urhh 39C.@rd rulhr&i de3iE. u.ff * @cuzd cu nidhr Ln ar..lA' c!hturi/tr,tM &&Mfr6 olbsiw.hi.i mld . Dl&ro.ct i t@ 3-6 il.,.toi il.,.toi o DlRro .ct f@ sr. sr. d. 3-5 dd diilProm.ii.n, df.bri6 d" ?-5 tila ilqllt

V. poliomielitic
. s EinsroLdzd f.bE 3'o C..pc dtE ii96!ru . inrFln inr.&l d. @ 48 @ luMr Dclliziil.. .1. p.r fi li|nitate. diern@, mrcpr.gii tu . sutrt dfeidli in sD..iol nu hii Mblor arf4i@, o9oi .ai .i habr.lor $De.idE . 5..h.1.1. @nrdti tur Danreln mid'turE duild. a orrcfE nd.ubrn fisarti .u rulbu|6i & dr!r@ lo .oeii. 9i ai

V. poliomielitic
. Caroc?Gristicih poFolitlci ft pollo: - af.cfcolil onurttc arurc nxrs.i&re, ld5lind - hiper*lezii ti porsteziilh pcriooda pordliricif, . ROT: opoidihirudt. p6id hrp.r"oct'v., 'n4rol h disparilic.

)i

V. poliomielitic
> 2. Ffr n+erci. . Fm-hzirhpa{d'c..fiihd qMA dordrl ^r.rcii o@dzdd riD 1iD L! ry'. . sunt df..rdu eLri si @renii tutdi di Mtlor dmlirii ol. Nsdtld erDidtdi. d 6r..hiL.: dicfrc4m.r, dbdoh'Mh.'rf.fu3rdi. - tulhtrl.i .L rirhului rc3Dhctof , ddtoritd dtidii dhr.ilor bulb.ri; tulirariTn d@lutirr.- ob6rNdi. troh@bfo6'.d, tulbur{ri .h vdrbi|, lo (@ $nr @i.r. piq<,.@ dnolr'4ei f.e@E d. dre!. 'i

V. poliomielitic
>3- Forhd .hccfoliflcl . Ap.re?ncodrulporoliziei sau Spinol prognostic oscendenie dre un 9i arov. >/t. Fofmdqr Dorollzlllzolota olE (poroliziile n.rvilorcronini, d. nery f ocial) evolueozt banign.

V. polionieliiic
. khid.ld.&b/idd f.lft.ataL., E+adi'Mrdo eftt. nidrri, nc *ftnlil dr.rdn. h'Fdn. tr4!. 6frd. lrhlreljft;i6id, -dc!. E i. d cf.qd d. iE rmnr@ nc uh FrgDnk
Fii

V. poliomielitic
Tffiritl&*Edie, d j'divi:i ' Fii 6'M si di.Edh - lrui .ftiiFifu','h|d'dtia' hbr.Jiul ffi dFEii d'lor o iEFrd, @fdE.E dh lcni, r.sE Lfids th irdd rA,i s r+.tuid.

ctd dbift r@.

rii

. eft o b.dl iiDr4 d tipl.i@lr

'&I'd!
.

iniire&

. -D. Pdaardiir rqddr . E#didfE alir.!i3i. *,ri ffi & tunfaft . srm'wb&dd*tu nd bolffill.rdd {@1, nid 6it4i roiMr F& h.hilvn Fix

(dl'iabri Eudi $r'i 6ih'd) 3i ltt*@di6s d'dct.dn|o'mitEllh e .{rr..d k'* !i d Et''. oid.rn d'mrc

6rn.

s',.dibrifr

e.r.dn

V. poliomielitic
,'bolmvll se spitolizelzl pe tootd durda 7 reorimir.a 6Mlct enrufuiln .olc.rivitate firi sDecrol lh iectorul olihenlqr) a. foc? ijuDd3 luni de lo lmbolndsr" (.bl"rla r' Conroctfr coDii uni cdftnrimlt 2I de,zile, rcifEli, rjptuvlghat Rni@l fi

V. poliomiclitic
' S! aDhcllersoon.lor cxDlre riscuh d? lrnbol'ldvii.: . persomlului n?dico-$rnitof , . coiro4ii dih focdra ' 5c foc" Dnn admindrdrco d IoG (0-14 hl/ko @ib). 6re efi6c" nlointa cohrictutii infe.ldhr si of.rd Drot.ctt? t

V. polionilitic
Piofiloxic octivd . A fost posibil dolori-fd lui Ehders, care?h1949ou Weller ei Robbins, culli\6t v. polioin culturi celqlare).

V. polionielitic
. Trltdhcnt . Este iimptomotic. . Rlducereqdurerilor. spqshelor, mentinello hidroto. respirotiei, . in convalescen$, kinelofiziolerapic

Fonilio Orthonyxoviri&c
. frt'.hy:onrut$le !m .9.r1' .i'.Ii.i .i ub. inf.4ii spirdrorllftur., !e.i gl!E,.u ihPo.r d ln .oi<i6ii/!.h&hii olobdle .bl6!d ;wrdht t hoi dl4 ih f6'!dul o-iib sl bdtrohild. . Oa6iM . d. drdlr6.rd6a.ff.itr p.nt! rBorFrdd. 4lul@, aFa 4qf.tsl ir sM.rtt. trreomi M. . T4nt@l & orrhofvrdi@ri l. d.o$b.Eb d. !.f.rnyxovrNtur cdr, d.sr qE ll*enrs ientrdr@E de lrds.E .L @luli, tir dif4ii. d md.lirat .L fiEt'ld i rtpli.G.

Fon|lllo frhofiyxovirido?
ih 1996adltdd Ih adltddtdshoboml tdshdoml dc ch.it Ch.itic@ !i \ TdoFhi. Vifth d in.lc ln OrthoMovitu$rid@ @iul fiwoto{tu. @ @nid. s.ui* dv6rd -9.errErdli s'h' hr! fmi|lli, in dNl 2ooo . 'r ch. ti Srndi: divi&i gdl !.tleh:dtM ln , B.C, a gtril.: > g.rul lnflEu@iru3 ]( d tjPql d r gdpdl }{, > 9.hl Intlahz.riM I cu ripul f, gripdl S, t Fnn liflet@iNr C d tiFrl d. v. griPolC,

>

frll!$or|ovi.u!,

.u riFrir. rhoro,Dhod ri

&|nrrila Influanzovla|rs:A, B, C
. Vi.iohii61ospcfpolihorf d.lo foriE sfrica Io fornE fi knntod...

ganurile Influ.nzovirss: A, 8, C
.k'ffi .h.|'@i dou'.i oJ.dfo d.|u'irddr'ddnEEnn'fift5091'o'i .Eft*ffi.ri'sbdiodL^ dn 3 v qrFrci* f.M iffl 7 q|r4 'c . F.t!E*ftdeonini9.,'dRsronsbiu&@difi@ '4rft.

. Virioniisunt?nv?lili, Pe$rprafahfhveli$thi virdl .. ok.rvi nigteproeniicnle,3ic!li, .dre dudinnsiuni de 1O{4 nn lungin9i esteconstiluit din }.RN,prctin. ' Virionul lipidali cdrbohidrsli.

6"|I.ril" &Iflucnzovirus: A. B. C
. Infeqiibsrip.lcd riDllA*l'ltdsc ai lo @ieL dwtie dt h Ddrtr, .llborie (r.8, 969t , tdldri cdnrdEl ul6i Dot sd 4.d h ontinf.4ii situlroE h orn .u tulpiii m|; si dnitulc ii osrtul .L ciii dxr., .u tulsni d. lo $..'i dlfdir., dor'^t d. @L$ r'p. opd iu tu|p,tr ,nr r..c@, D.'t1i! c L aifccrti. d. c.r!6lDdl (ln 4 Jdiob& FMi@ perFr rup4i d. Gmffrlui ai hdrtri" ..d!rd! E|rfru Efo@ -emld i!.ddi.dr)

gcmtifa liflucnzovinrs| A, g, C

' A.rl'4l ncL@Dsidc df.rn @rfi.iror. d riD $r-rueld 6iFl {D.e6na d'lqid'.Mi.trc .ar. trc iFii,l,s,o . vhioel qri@l DMrrrn ddrd f.ffi d. Ni..rii: h.i.a|'lll'iE IH^) $ Bnrurd@ N^). ' L! ar.rid @*ld 6hliE libi&. oh@l'D'd. .i oli@DFt lE wti d.rii{r. din iidrlbr'E pldiEri.a oti.luLi O6rdd,F.liolcod'fr@r & . Pc $Dmfdn sir dkee D|sirir. ft f6d & .tls4 (+ilar), d diE viiioel e ci6@:d d. ' Dord llFJd d. .ticlli st ahp..tdit :

6crarfilc Influcnzovirusr A, B, c

6!nq"il. &f lqrnzqvinrs

' > . PflnrE slonwL & H/( r.!sr. o qhd @r..ai. ir. Ni@rii. 3rnktui d i|.gr d. ciurad, Miit ri|dltrd@ Nr): tl.|,q&id.rL rut 4ir fof@r. di. n@FlirdEi& ru..Flrde 'i tL.llqinid.E nviE @lutiE@ ruilor dticlL viEL fdsFPid .Ef.r da!&!lui .L vifi.^i inf@tdti .i 4fu@ Lr .ltE .ltc t .itrii (ol'r.L dc.6i lodl d. ii@i.} ti$ld. In i.f..liq on@h- M fa irad flidifi@ ftfttui &d. k iiwlul .'ldltui qi'iri,u d!qP' r,o i!.tdu elpr{rd

. Fd!! de acestecomponenle ontigenice dparodicor?i spadifici: o inhibitori di hhagluiiiirii, gi anhibiiori o nutrolizanti oi octivitdlii neoroniniddzice.

NomGnclqtuFq vinrsfilor gripol"

'

offi o$e"ni.ot vi.ote "iro*"t-prutcinci

Oruhdrul tulpinii, onul izotthii, Dlipuld" HAii N.t . x".tr'p_lu: A/Sobn|orlshndc/3/z@6,/HrNl eN'."G.*r'"b-F6"4
hgldflr,

H*:FD'|

4 '

tuErchn t +ciri.6 e

"ffffi,fl;

o"o"* t""eind e.oerdricd

. h.

@!q.rr {Fh Drtu!

Pffr*}

fote, db

c@h'el

6entlril. &flwozavirus

u,ud
dp 9itd, b.!Eb|it, hb@di'4 Fid{ir4

2.er&r6trd"ro.l@

i
(

:mffi5H**tuHffi
.

' hertrtldc,,&rerrirft.

iirftilKo,?;@eDii 6,lldFtld*stu.@ibfr

,) ( (dih. jr,fr. -+mea. ). )

ffiffit#Ejk:#:ffiffir*.
ed!6h't1dri|'qrtr

nDdirarrib..h'

i, --*.*

)i

ft1!"i'!A

6nrl Rsbulovirus Virurulurllon(VU)

Eft.r.'rli d6idc d F.rdd ddnr_

rrtrE#;r::tif *.#;1*:TJ*|J#EI-.!

g,xffi#lffiRff{*fi:T}"*#-

ffitil*li:*""*'**** iifi'*tr3i*I.f'*S1r#

#ffiffiffi#ifffiffi""

clnic Porofldno ^.D.cic ?td.n

Virusulurlion(VU) \:
c! (o,..iodj)

lj (1

r ffiffi*=$**ffimr* 'ffiiffi***,**n._*:*6"*,"
. E r. d. 10-15zit. d .vol,4i .rrotihrr@ra

urlion(VU) Vinrsul
Orhlto
. rrdi f@nr dtrr,6r. drd qrb.rt i..la 1G30%d'nt rrilddra & f.t {, fn$n,.rri . Aht i.flmlh r@ldt.4t.mid.turo.d, rir@t 6h.L dldsr4in 2!t 'llr . Ewlulid 6i. flwEbild, d duBh d.8-10:ila ' uEdi (5?-) p@r. d qd{ drEJh rcridh,{, t! f.ei d'ft F;r. i!e' ltt oEt ow'td 3i rct ld frr! did la d.'. o b 3ra

urlion(VU) Virusul
#!,rifdofohd d'r..i f!{dr. 4tui

. {rldtu(qgrbarEdfN,dh h 0O5r d ft , h..i..4rr .rdah.rd.a.. EBft 'tHn, 4LLb h rd4)

(tu'. d

d'ob.ilru ltdrFh

Virnsulurlion(VU)

6"ru1 l orSilivir^us Virusrl rylcolic .

Esrunribovinrsdnv.loDdr c. to.. o!r't dinorul l o$ilivirusfimilio

. E+e ogen'l'rl etiologic al nrjoli.

' .ioirl 6t ARN cu ablidd h.licoiddlic4t\! crlc @D.rit d? Drrtim ri, ndrrix, si lo .xt rior'D.rlos frirmor din &blu $.of liDidic d.riwr'di. npJnbrqm celuLi i|ifd6i. 3i sDrorfialicorotacil h.mletrtl'ih{i ri pr6tclft F (d furiqrl).

,'u-.l!rdlful'6'id

Virusulrr4ieolic
. Pofog.nazd . Vilrliul at{iolo3 pltnrndr ln orgonitn prinoerosoli, se replicd locdlln mucooio respir.dfoaie 9i conjund;vnli. Diseminozd ?ngnglionii regiomli, qjurin sahge9i dpoi?norgFnelE
edd

Vinrsulrujeolic
. suit bolnii & oFE dd (B d Frfibri fibi) pn^ na ! " >j'did,P.il.5i.tF!4ll@fuifub r..'rj!i|fud9b.d. Fr p'ctbL plt99. .ld'@

6di.'ad ]&iM,

tiin Lhr{ tu odro-E:d lorof'bi. tu* r,.4 u'td e ffik, frtu r'.ir

Virusulqieolic
. st Mif8rd cu f.h.t, &hi esii n E ri@!i, . h2Madd & b@lddd,i outu.e 'ileiNlc@ obrqii|d. nrci D{er. dl6. (*n_ru| lui (oplk), opd! !i@Pri.,c4 d|roE dN-rrui rib. e Hinra eub f6rm uM et. mici & cul.@ ^poi (M illi.for. .&p!4 tur, 6rif.hr?, |Mi @ ffire @lo@ulo.rd c|6li&rd &s@i&;r. ..riF.lord h Dolpoe. a,flwnra ih . Erhtmd r. 'l?frrijid @ di+dr h

ti
)

Semnul Kolplik
Coipli.4ii:

Virusulrqieolic
> @Dpli.diiL Eta@ @urd p6r'.fatesE t @hili.4ii E|a!@ ah.d.r. (@folor.i.lit @. Far6 st @oin h 2 (DoE@fo,ito

dpia,iar" & loe5fi),

&lao-zirn.ri9.4n - PEssr@ perdrn.9o.n

a+a h 2-r5 ob d. h i.f..lid ru@h..li 'ncid.nb l/ro & @i, *Th*t..:r. e fwrr h

todi

Virusulrubeolos
. Est un virus ARN, sfe ogertul liologi. ruboli, este o boah d gravitdte medie sdll utoard, dor n ilnporlontil Pntru grsvide unde inf&la dr dcst vrrir. pdte pt'odlc con otnir.nt leziuni fetusuhli 9j n lforhatii congnrcle. - Rlbeoh d fosi rcuno!.utd co .ntitdf ndologicd disrinctd de n{iold ti 3@ldtind ln 1881.

UL,
1S

Virusulrubeolos
N@! FE(e'ni!o'!. d. qd und d,tualld fi eorylFhi .@d'!!d.rdart

Virusul rubeolos
- nlo|fo|'lotii ociar.: cdoractd subtotold sd! iotqld ddesa bildrcrold 9i reiinopotie, nricrcof tdlmicg glorcom; nalforfiolii cardi.4.: prsisrcnt @mhrki dririol dinir. oortd Si orferd pulhomrd ii pul,nondrd, stenozd pu srenozo nondrc,mrodrdrm; miocarditd; - halforhotii dditlv.: surditqtcj - |r|olt .hotii ol. sisl.'nrului n"rros c.itrol, hicrucefoli?,lhftirzireFihonoiorie-

iif.4rr'rigtpS.d12rQi6l6 hr.i;i.i'*&;nnr*iffiir .

@id.ii dh c8!L d'ial @ e k hi{r,4 anl{kL lEDa'd d Fim 'rud fi $tu ri lridl d. ekiin !tur ^wi 'iiEh

't

r\ .ll iL l) if i

o,

'l t)

FomilioRhcbdoviridoe
Sunr virMi @ infarazd plotrt , . Vi@rii. p&dk ercre .@ s p.t iEMire ld onimhlo.. 6 p.in intardit . DeMi@ fqi|g NviE d. ld .uvnnrul or.4 /tabdar{bd.toiq) si dro &fiFst fod. O 9.@lV.zi.ulovitu o 9.!, LylwiE, d {..ia .@ d+.ii& vidul tromtjt V. rnlk, i

I )

11

Virusul robic (VR)

. Err. .irul erbkgk 6t rFb6rx, bt 6.. 4i6.vrd din dtidir.r. . st'nii fuxtrrui.lc @ f6t ratir.t & Loir . 4rfofitd.ilindi.deodrqif.r.tutuni,r! GP..t de ctJ9 d dr6q'.& t8O//6 ,; . Est M utu ,PN l@@tee. l@@ree. hni.r Nucra.qrsi& @ irEi'i. h.ticoiddtdiif&@rd ^xcra.qsid. o@er rh Jurl| @td @r&l .t srtutu,i, ?.r. eru rdtr a u. .fintu inv.ti9 t4rdic !, soiati de en..ffdsca sr! ! 6 d4.k l 1l ",/

.t,

Virusulrobic (VR)
.*fie+Hffil#*'i*5*h.tP.'t]l|.5toc, . rr! s 4furdr)r!p&ir@d m[*g*(t ^+rd .
v. r$ic * idid 16 iifirir. rddi4irb. uv, rx I

Vir.nsulrobic (VR)
. vrNsllPqiru'dc in oDqi,s Dfln fts.drw d. @rE bre o darir d etiw iirf..rqrn, eu a!g.n ti prait cu titik, ri pr4ik ritikr iif.(roti. iif.(rot, s rin rii $l4x d. @ntiruirdr. ote r.gl4hr!tui d!,ici c6.d vrE ,n @ir@r.u vlrusntubi. . t! lo.ul vir@t & nulrrDtr.t_ ra s 'nfar&ii eiFet t|@ vnr ErotFP, ii ,i&Drfii nr.or.'.r d. @ritetiid .t L ron4iuiEa EMlrdlor oPoi* diqi'Ed @rr,Pd

filkt d chii{.1 ' ilHlJtrPlffi'**xrol**'n

F.n.t|li

L !9.4

' .ifng $is*lgtr*"""!'&

xmi #**l##?sf#1af*f,ser,,ff

or41,ftn 4zd'h

v'.!h orc toc ft .ifoDtdsnc n './hiplicara uroi d, lnde s d.tedrazit irE||ftit @

Vinrsulrobic (VR)
Inc$atto
R.bid td 6|r

. Dis.]|lrmqe. ln c..!r ?st. mpidtt o.rrnrhond ercet.tito mbi.ll filint. rdspu.3ut sii amrd 'nun d. . lrdr tulbardri colrporraiient,

d o |nut@. . P.cz..ld viraelui s poot. d.re.to si ttr rrlcllr rerp'rdro., rut hjlt .qrdid._ nrcnr, pdrcrcqs. rdiiil. .orEc. foti@h

hipf adrobitif oi., ir;'robi tiiirrl ii traainu

tts,irri filflg:,H# "i,.""H.

lr

'E

? scurr, de 2-4 z' tc_d o

ffi"T.iffi{ffifrflil#k I
,

Robio lo om
.
r, rdi! irici (.!cri.d)

friffif;1iili$qf;t"1"**'t"'tr'

ffiffiffiffiffiH"##sf#'r

ffi*luffi

frIgIgr! Pt,.rgr.t4 ldhhr,rr,

Robio lo om
'..4 ..fo rd .frd td d ' l i E l i q n ri 4 r[ffi

-N"9",:9Ip! Bobca

ffiilffiffi#*sffi:
- d- id:,- ,- , -

"ilffiffiffiH##'.
it#,4f*"ts5Hffi 5dg.:*1j."s}*

1i

I
I
Vinrsul robiclFJ
. s.rorropq sou odminrjrftr dc 106 sp?6frc?. . l frt ^cstdserecohondithc. dtur'tor 9.!v!, od6nci,h coD.oar_ nanDre prcdus? d aninql? dlbot-ic..

Virusulrabic (VR)

ffi*,q*WP'.ruffi^rri@

#,ruf,F(*ffiftffi#"strlYk1 g.rvi). ftlqid .|etu

r. tuii;ia

fltotui

d. odqiE!

tubi.?i in

. Voc.ihun onti.obi.. .sre s|nqam nr.todd .ricr.nrd d" p..veare q robi.i

13

Vinsul robic (VR)

. T|1dtdhcrlf

FomilioRetroviridoe
' Esie forhot8 din virusuri caresunt ognlipotogent ai vedabrrtlor (om, pdsiri,rptil,p-lti) momifere, 9i (inscte, nvertebrotelo. rnolu$te). ' Degiprezintb coroclere morfol@ice pecorele proGocd ( corlohe, infectiile se pot exprinodivers, de lo forne asinpfonolice, ) ld monifeslhri clinic" \i 9rove.
(

. Tadtolncrltul oiiivirdl ru o ddt t?zultcte.

. 5c foce seaotetobie concohitntcu voccinoreo ontimbicd de srvrcii speciolizdfe.

\r

sll

\ ) ))

Virusl HfV
. vitutul 'nmdefEEi!.i t rFd.i.b., fdill.t ftE df.rJli! (HIv) oodliE lrl}ivi{r.

Virusul HIV
. Stfirtut{ . Viruslll ore un diotneil! de ccq. l00nh. ' ec'toh ARN, honocolemr. . Are trei calegorii de genei hqiorc, reglofoore 9i occesodi.

' HlV I si HMIluhr d.rti .ti.loi.i.i 3i.d.ntului d. ,ru;Edcfici.^r! dol6;'td (slbr} . A.Dlhrr 6 cdit r. clini.n th l98l. d @ntul .ridl@ic . foi iek| Tn1983.ic d[Dd ld di sID/t a fdi midi.n . '{$$diM fni*t zoo .Erdanicr &so hile.r

VirusulHIV
Copsido
. Are si|netrie icosoedfica d fornd cilindricd saude tnrnchide con. . Ceonoi imtortonti enziml cale r.Gv.t sfonscriptozo (capobilish fronsfonne ARN-ulln ADNpaovirol, ovandrol d. ADN-Dolin"rozd-ARN depndent6 9i ADNpolimemzd),

HIV Virusul
. HIV Ddrtud. i. ..lul.l. @ @ h r4mf@ Lr tu .Ctod dD4,ln ufu fuid,j D.Dlcirlui d i6bF..lulail . ih drod6d @ l@ d.sD.lddra . sitr.r IDN{i!' NviMl d r|ln{t!a?nemmi eluld * cu d[r6tu]'slrzi2d 16 iit gdM .diud Dnr Eu3rEs4iprd.i, . EIh;@ vhbiild FinTh|lgsie. dii ..luld @dd c raliazr

Adsdbtlo 9i p.r"fdr.

vinisilui lh

't4

Virusul HIV
Pdtrrl|d.r"a viFrsiui in orgo,tisr s. tdc. urogcnit l., ?c.tal. rar orolc Pfir - ru4r.i contftt hete !4r homrasll - Drirurdl, da ld ntdrd h ffii - porcht.ral, prih .olulii d? @ntiruiiata oL loumcntlor si nvrcodselorini.tiio.fourclu.d. raruqe, irdnsfuzji @ s&rgc ihleoft | sd! dcrivdte conioirandtc. imn:Dhnturi d h domio.i iitatali.
. H!V.tr.3.dibil

tqltt

il. h .aqtr fEr.r rr .lrrikr

h .il&'{

uneda s i6cfi6rd

. E3r" irfici.ntd lmdiv(M ld 30 hin ld 56qC. .er. dilrE drn rc h b 6alocFii fErh.c e,r. iEcriwr durl 20 hin . Cddm @;fi lsodcn dkhrg. ri.F & 2 h. . Hwatt @id.^r lo mdi.liil. UV. . Ph{l oDrih d. d.zwh@ 61? & 7l 6r. di'rtu h pH-lhi aYrr6. erb ! ri D.er. r0. . 5ub6r.d.L chide cl disra srr:.|&l & a|grai.n 2X i. 30 ni.. Elx'dul-i|. h'd@ 6t in 3O6in- .l@lui .tilia d. 7Ol d iodi .L_101 in 30 nin di .wni &riwr.L d..G.

VirusulHIV
Pai.fr.
d rellbrlr@ ' rifid.hdoohbrrco4 @ft h Fibl'@{ tftrdcldtfrgt l' lrhfdrhL l

-\I

Virusul HIV
. APc. L .ttd ltbtbtl6'i I * ho'{f.di prin: - cE5t.@ jim{eh.lor T cD8 (.d * nt.itn .F ilia .rtidp r i@arEli&iti. . Paiod.L & inf..li? lat ntl . -rl@ d. fom .3inrtffitict ln lft .linic mnifAtd e t@ tnrr.ui! idarl d. @ 2 di (5% dirltE F.L,t) D6nd h 104i (sOX'dfir

m, Ftu,i|. @li6ni bbridi ! tstur. . ItudidtriirEFfui. & rar o t@rt fd,rie'd eea did k lihf4ibL cD. n edtf-h dro,rdft. r.ifad , uuimvrtr rri.Lk!.ft&i|l1r*fdts6b &qi'n. fi. libr. f* @.tcr a liffeirL CDl o m,6.ftr. s itu||infdi . kdtEEtil&hinLd Elifr !' lr $i'l

Vinrul HIV
Toblou clinic Clcrificoreoinf.ctii cu HM odult s" fdcein fu64ie dc d|t|nnitecaiteaii >clini@(3fodiul /{, B sduc) 9i (scidereq >imunolooice lihfocitelorTh cb4 sudzodlhh3 sdusub14% din totolt l litnfocitelor, dcesleoindicand siodiulSIDA}

Toblou clinic
. Pai& d. iftuS.ti..'r ld 3 bi-st.Mii.@rt lnrE.ite tib ladl clinl@:

(rind!6 ctevitul), - i'd.4i. 6rrd plr.cifid th$lit d. f.6ri. o6.r6ii. fdiEill- crrehli apli mdlo-pord@, lihfo&iFFft gw&liratd p@r. dn 2-3 +l&nai, tuiduM . ,iq3t6 p.ri@dd Ddi. dft pAd b D di.

Toblouclinic
. nd.lriLd nt'.i'lfui . r-ifBirib .t'd4 drrJortut idtu 3 dl rirt r.!.in 33Fc dt Ea$ D tuh & 6 |jir ddJc c Fidd hdi nn J. o tnit. - .dq |:.F:frand&Midtd, Mbodtlr.ii.n - lrrrd - rit&lii !.M*

. coEr!.d.

r.didui fi.d d ihf.qi.i a HIV,

Siadisl C

. tc{d... fiar L g|qroi.. 9 - r.bd p...isr.dit & .tiotogic '!.9fei&rt, (hkrai.E. - infet d 9cfu i.rortu4ri " E pht|l! tifi rodijt. rddiw rutfslibi

sEt _

idiordid,

o tohoFiE.

' Fofr tlva <L l$rfsr@ o @fdo!.ti.i HIV .rrr. o.e4o c.oarrr @ srDA, AD. ( ltrs

Efr^{#tffi,ffiL'.&r'a,urrhrJi

mr*''.r. l*r;ryflbihq* a"a

16