LP 9

CAPSULE GELATINOASE TARI (OPERCULATE)

Caracteristici:

.......................................................................................................................................................
.......................................................................................................................................................

Clasificarea capsulelor operculate – criterii:

a. dupa eliberare
- cu eliberare conventionala
.......................................................................................................................................................
.......................................................................................................................................................
....................................................................................................................
- cu eliberare modificata
.......................................................................................................................................................
.......................................................................................................................................................
....................................................................................................................
.......................................................................................................................................................
.......................................................................................................................................................
.......................................................................................................................................................
....................................................................................................................
b. dupa marime
.......................................................................................................................................................
....................................................................................................................
.......................................................................................................................................................

b. dupa compozitia invelisului

.......................................................................................................................................................
....................................................................................................................
.......................................................................................................................................................

1
FORMULARE
1. Formularea invelisului capsulelor operculate

GELATINA Capsule Capsule Capsule

PLASTIFIANT (glicerol) operculate operculate operculate
APA transparente transparente colorate opace
CONSERVANT incolore colorate
COLORANT
OPACIFIANT (dioxid de titan)

.......................................................................................................................................................
.......................................................................................................................................................
....................................................................................................................

2. Formularea continutului – umplerea cu pulberi

Excipienti:
Diluanti
.......................................................................................................................................................
.....................................................................................................................................
Glisanti (lubrifianti)
.......................................................................................................................................................
.....................................................................................................................................

Agenti de modificare a eliberarii

.......................................................................................................................................................
.....................................................................................................................................

Umplerea capsulelor operculate in farmacie – etape:

1. prepararea pulberii;
....................................................................................................................
.......................................................................................................................................................

2. mãsurarea volumului aparent de pulbere, verificarea capacitãtii de curgere;

....................................................................................................................
...............................................................................................................................
....................................................................................................................
.......................................................................................................................................................

2
.......................................................................................................................................................
................................................................................................................................
.......................................................................................................................................................
.......................................................................................................................................................
.......................................................................................................................................................

3. selectarea mãrimii adecvate a capsulelor (numãrul)

.......................................................................................................................................................
.......................................................................................................................................................

4. pregãtirea dispozitivului de umplere: gelulier; aparat Feton

5. umplerea propriu-zisã a capsulelor cu pulbere;

- Etapele procesului de umplere sunt:

a. introducerea capsulelor închise în alveole;
b. blocarea corpului si deschiderea capsulei (ridicarea capacului);
c. umplerea corpului capsulei prin nivelare;
d. închiderea capsulei

3
 6. conditionare, ambalare;
.......................................................................................................................................................
.......................................................................................................................................................

Rp/
Fenobarbital 0,10 g
Lactoza q.s.

M.f. capsule
D.t.d. nr. X
D.s. intern, 1 capsula x 2/zi

Forma farmaceutica
.......................................................................................................................................................

Consideratii de formulare
.......................................................................................................................................................
.......................................................................................................................................................
..................................................................................................................................
.......................................................................................................................................................

Preparare -conditionare
.......................................................................................................................................................
.......................................................................................................................................................
..................................................................................................................................
.......................................................................................................................................................

Actiune
................................................................................................................................................

Controlul calitatii capsulelor – FRX si Suplimente

1. Descriere
Capsule gelatinoase tari
.......................................................................................................................................................
..................................................................................................................................

Capsule gelatinoase moi

.......................................................................................................................................................
..................................................................................................................................

Casete
.......................................................................................................................................................
..................................................................................................................................

4
 2. Dezagregare
.......................................................................................................................................................
.......................................................................................................................................................
..................................................................................................................................
.......................................................................................................................................................
.......................................................................................................................................................
..................................................................................................................................
.......................................................................................................................................................
.......................................................................................................................................................
..................................................................................................................................
.......................................................................................................................................................
.......................................................................................................................................................
..................................................................................................................................

3. Uniformitatea masei

4. Dozare

5. Conservare

Produse industriale sub forma de capsule operculate

ERDOMED

BILOBIL

PADUDEN 200 mg

ACC 200