Tema 5. Glandele cu secretie interna.

Clasificarea hormonilor

Lucru Individual
1. Defineşte hormonii.
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2. Explică controlul secreţiei hormonilor glucorticoizi (A) și tiroidieni (B) prin mecanism de feedback.
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A B

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3. Notează în figura ce urmeaza hormonii (dupa structura chimică).

4. Explică mecanismul de acţiune al hormonilor prin sistemul adenilatciclazei, conform schemei ce urmează.
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5. Explică mecanismul de acţiune al hormonilor prin sistemul fosfolipazei C, conform schemei ce urmează.

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6. Notează etapele (1-6), mecanismul de acţiune al hormonilor liposolubili.

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 Lucrări de laborator

PHYSIOEX 9.0 Fiziologia sistemului endocrin

Metabolismul şi Hormonul Tiroidian.

Notează rezultatele şi completează tabelul 5,1.

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Tab. 5.1

Normal rat Thyroidectomized rat

Baseline __________________gr __________________g __________________g
Weight ml 02 used __________________ml r r
in 1 minute ml 02 __________________ml __________________ __________________
used per hour __________________ml ml ml
Metabolic rate O2/kg/hr____________ __________________ __________________
Palpation results ____ ml ml
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mlO2/kg/hr_________ O2/kg/hr___________
___ _______
With thyroxine __________________gr __________________g __________________g
Weight ml 02 used __________________ml r r
in 1 minute __________________ml __________________ __________________
ml 02 used per hour __________________ml ml ml
Metabolic rate O2/kg/hr____________ __________________ __________________
Palpation results __ ml ml
_________________ml _________________ml
O2/kg/hr___________ O2/kg/hr___________
_ ___
With TSH __________________gr __________________g __________________g
Weight ml 02 used __________________ml r r
in 1 minute ml 02 __________________ml __________________ __________________
used per hour _________________ml ml ml
Metabolic rate O2/kg/hr____________ __________________ __________________
Palpation results ____ ml ml
_________________ml _________________ml
O2/kg/hr___________ O2/kg/hr___________
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With __________________gr __________________g __________________g
propylthiouracil __________________ml r r
Weight __________________ml __________________ __________________
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 ml 02 used in 1 _________________ml ml ml
minute O2/kg/hr____________ __________________ __________________
ml 02 used per hour ___ ml ml
Metabolic rate _________________ml _________________ml
Palpation results O2/kg/hr___________ O2/kg/hr___________
_ _______

FIŞĂ DE LUCRU ÎN LABORATOR

Partea 1
1. Care şobolan a avut cea mai rapidă rată a metabolismului bazal(RMB)?
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1. De ce ratele metabolice diferă la şobolanii normali şi şobolanii modificaţi chirurgical?
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3. În cazul în care un animal a fost tiroidectomizat (i s-a aplicat tiroidectomie), care horman ar trebui să
lipsească în sângele lui?
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4. În cazul în care un animal a fost hipofizoectomizat, la ce efect ar trebui să te aştepţi, referitor la nivelurile
hormonale din organismul acestuia?
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Partea 2
5. Care a fost efectul injecţiilor cu tiroxină aupra RMB la un şobolan normal?
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6. Care a fost efectul injecţiilor cu tiroxină asupra RMB al şobolanului tiroidectomizat? Cum diferă RMB,
în acest caz, comparat cu BMR al şobolanului normal? A fost doza de tiroxină în seringă prea mare,
prea mică sau corectă?
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7. Care a fost efectul injectării cu tiroxină asupra RMB al şobolanului hipofizoectomizat? Cum diferă RMB,
în acest caz, comparativ cu BMR al şobolanului normal? A fost doza de tiroxină în seringă prea mare,
prea mică, sau, pur şi simplu, corectă?
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Partea 3
8. Care a fost efectul hormonului tireostimulant (TSH) asupra RMB la şobolanul normal?
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9. Care a fost efectul injectarii hormonului TSH asupra RMB la sobolanul tiroidectomizat? Cum este RMB in
acest caz, comparativ cu RMB la sobolanul normal?
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10. Care a fost efectul injecţiilor TSH asupra RMB al şobolanului hipofizoectomizat? Cum este RMB in acest
caz, comparat cu RMB la şobolanul normal? De ce a fost observat acest efect. A fost doza de TSH în seringă
prea mare, prea mică sau, pur şi simplu, normală?
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Partea 4
11. Care a fost efectul injecţiilor de propiltiouracil (PTU) asupra RMB al şobolanului normal? De ce la acest
şobolan s-a dezvoltat o gusa palpabilă?
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12. Care a fost efectul injecţiilor cu PTU asupra RMB al sobolanului tiroidectomizat? Cum RMB, în acest caz,
comparat cu RMB al şobolanului normal, diferă? De ce s-a observat acest efect?
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13. Care a fost efectul injecţiilor cu PTU asupra RMB al şobolanului hipofizoectomizat? Cum RMB, în acest
caz, comparat cu RMB al şobolanul normal, diferă? De ce s-a observat acest efect?
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Semnătura profesorului ____________________________