Documente Academic
Documente Profesional
Documente Cultură
617.322:616.1
633.88
633.82
Referenţi ştiinţifici: Prof. dr. Mircea Pavelescu – U.M.F. „Gr. T. Popa” Iaşi
Prof. dr. Ilioara Oniga – U.M.F. „Iuliu Haţieganu” Cluj-Napoca
Toate drepturile asupra acestei lucrări aparţin autorului şi Editurii „Gr.T. Popa"
Iaşi. Nici o parte din acest volum nu poate fi copiată sau transmisă prin nici un mijloc,
electronic sau mecanic, inclusiv fotocopiere, fără permisiunea scrisă din partea
autorului sau a editurii.
Anca Miron
snirpuC
1 lulotipaC
1 ......................... ECAIDRAC IEŢNEICIFUSNI AIPARETOTIF
niţnoc erac elategev esudorP .ecinotoidrac edizoreteH .1 .1
4 .............................................................. ecinotoidrac edizoreteh
5 .......................... ecinotoidrac roledizoreteh arutcurtS .1 .1 .1
6 ...... ecinotoidrac roledizoreteh la cigolocamraf luliforP .2 .1 .1
8 ................ecinotoidrac roledizoreteh acitenicocamraF .3 .1 .1
01..... ecinotoidrac roledizoreteh ela ecitueparet irăzilitU .4 .1 .1
01...................... ecinotoidrac roledizoreteh aigolocixoT .5 .1 .1
11................................. ediolatigid ,ecilatigid edizocilG .6 .1 .1
21....................................................... abreh sidinodA .7 .1 .1
41.................................................. abreh eairallavnoC .8 .1 .1
61....................................................... muilof irdnaelO .9 .1 .1
71........................................................sublub eallicS .01 .1 .1
91..................................................nemes itnahportS .11 .1 .1
12.............................................................ărutpeceR .21 .1 .1
52 ........................... sutcurf igeatarC .erolf muc muilof igeatarC .2 .1
52................................................. ăcimihc eițizopmoC .1 .2 .1
92 ................................................................ cigolocamraf liforP .2 .2 .1
64............................................ ăcitueparet nî erazilitU .3 .2 .1
05....................................................... esrevda iițcaeR .4 .2 .1
15...................................esaotnemacidem inuițcaretnI .5 .2 .1
25........................................ iițacidniartnoc iș iițuacerP .6 .2 .1
2 lulotipaC
65 ....................... ECIMEHCSI IEITAPOIDRAC AIPARETOTIF
16 ......................................................... erolf muc muilof igeatarC .1 .2
26.................................................. cigolocamraf liforP .1 .1 .2
86............................................ ăcitueparet nî erazilitU .2 .1 .2
96 ................................................................................. solf eacinrA .2 .2
96 ............................................................... ăcimihc eițizopmoC .1 .2 .2
07.................................................. cigolocamraf liforP .2 .2 .2
47............................................ ăcitueparet nî erazilitU .3 .2 .2
47....................................................... esrevda iițcaeR .4 .2 .2
3 lulotipaC
78 ............................ ECAIDRAC ROLIIMTIRA AIPARETOTIF
19 ....................................................... abreh iirapocs inmahtoraS .1 .3
29................................................. ăcimihc eițizopmoC .1 .1 .3
29.................................................. cigolocamraf liforP .2 .1 .3
39............................................ ăcitueparet nî erazilitU .3 .1 .3
39....................................................... esrevda iițcaeR .4 .1 .3
roliimtira lutnematart nî etazilitu elategev esudorp etlA .2 .3
39 ...................................................................................... ecaidrac
4 lulotipaC
79 ................... ELAIRETRA IINUISNETREPIH AIPARETOTIF
001 ...................................................................... xidar eaiflowuaR .1 .4
101 ............................................... ăcimihc eițizopmoC .1 .1 .4
201 ................................................ cigolocamraf liforP .2 .1 .4
301 .......................................... ăcitueparet nî erazilitU .3 .1 .4
301 ..................................................... esrevda iițcaeR .4 .1 .4
301 .................................................................. abreh icsiV .2 .4
401 ............................................... ăcimihc eițizopmoC .1 .2 .4
501 ................................................ cigolocamraf liforP .2 .2 .4
601 .......................................... ăcitueparet nî erazilitU .3 .2 .4
701 ..................................................... esrevda iițcaeR .4 .2 .4
701 ...................................................................... sublub ivitas iillA .3 .4
801 ............................................... ăcimihc eițizopmoC .1 .3 .4
011 ................................................ cigolocamraf liforP .2 .3 .4
511 ........................................ ăcituepareht nî erazilitU .3 .3 .4
511 ..................................................... esrevda iițcaeR .4 .3 .4
511 ....................................................... erolf muc muilof igeatarC .4 .4
611 ................................................ cigolocamraf liforP .1 .4 .4
811 .......................................... ăcitueparet nî erazilitU .2 .4 .4
noriM acnA
811 ............................................................................. muilof eaelO .5 .4
911 ............................................... ăcimihc eițizopmoC .1 .5 .4
911 ................................................ cigolocamraf liforP .2 .5 .4
911 .......................................... ăcitueparet nî erazilitU .3 .5 .4
021 ..................................................... esrevda iițcaeR .4 .5 .4
021 ................................................................. muilof irdnedodohR .6 .4
021 ............................................... ăcimihc eițizopmoC .1 .6 .4
121 ................................................ cigolocamraf liforP .2 .6 .4
121 .......................................... ăcitueparet nî erazilitU .3 .6 .4
121 ..................................................... esrevda iițcaeR .4 .6 .4
enuițca uc elategev evitca iipicnirp/esudorp etlA .7 .4
221 ....................................................................... ăvisnetrepihitna
5 lulotipaC
821 ................... ELAIRETRA IINUISNETOPIH AIPARETOTIF
921 ...................................................................... muilof iniramsoR .1 .5
921 ............................................... ăcimihc eițizopmoC .1 .1 .5
031 ................................................ cigolocamraf liforP .2 .1 .5
131 .......................................... ăcitueparet nî erazilitU .3 .1 .5
131 ..................................................... esrevda iițcaeR .4 .1 .5
231 ......................................................... abreh eacaidrac irunoeL .2 .5
231 ............................................... ăcimihc eițizopmoC .1 .2 .5
331 ................................................ cigolocamraf liforP .2 .2 .5
331 .......................................... ăcitueparet nî erazilitU .3 .2 .5
331 ..................................................... esrevda iițcaeR .4 .2 .5
431 ..................................................................................arohpmaC .3 .5
enuițca uc elategev evitca iipicnirp/esudorp etlA .4 .5
531 ........................................................................ ăvisnetopihitna
6 lulotipaC
831 ....... ECINORC ESAONEV IEȚNEICIFUSNI AIPARETOTIF
041 ................................................................ nemes inatsacoppiH .1 .6
141 ............................................... ăcimihc eițizopmoC .1 .1 .6
141 ................................................ cigolocamraf liforP .2 .1 .6
251 .......................................... ăcitueparet nî erazilitU .3 .1 .6
251 ..................................................... esrevda iițcaeR .4 .1 .6
351 ................................................................. xetroc inatsacoppiH .2 .6
351 ............................................... ăcimihc eițizopmoC .1 .2 .6
451 ........... ăcitueparet nî erazilitu iș cigolocamraf liforP .2 .2 .6
eralucsavoidrac inuiţcefa ronu lutnematart iş aixaliforp nî elanicidem eletnalP
451 ............................................................................ abreh itolileM .3 .6
451 ............................................... ăcimihc eițizopmoC .1 .3 .6
651 .............................................................. cigolocamraf liforP .2 .3 .6
751 .......................................... ăcitueparet nî erazilitU .3 .3 .6
851 ..................................................... esrevda iițcaeR .4 .3 .6
7 lulotipaC
ELAIRETRA IILOB IȘ IEZORELCSORETA AIPARETOTIF
271 ........................................................................ EVIZULCO
671 ...................................................................... sublub ivitas iillA .1 .7
671 ................................................ cigolocamraf liforP .1 .1 .7
291 ....................................................... ăcitueparet nî erazilitU .2 .1 .7
491 ..................................................... esrevda iițcaeR .3 .1 .7
491 ......................................................................... muilof earanyC .2 .7
591 ............................................... ăcimihc eițizopmoC .1 .2 .7
791 ................................................ cigolocamraf liforP .2 .2 .7
891 .......................................... ăcitueparet nÎ erazilitU .3 .2 .7
891 ..................................................... esrevda iițcaeR .4 .2 .7
991 ............................................................. muilof eabolib ogkniG .3 .7
991 ............................................................. ăcimihc eițizopmoC .1 .3 .7
102 ................................................ cigolocamraf liforP .2 .3 .7
302 .......................................... ăcitueparet nî erazilitU .3 .3 .7
402 ..................................................... esrevda iițcaeR .4 .3 .7
lutnematart nî etneicife elategev evitca iipicnirp/esudorp etlA .4 .7
402 ................................... evizulco elairetra iilob iș iezorelcsoreta
noriM acnA
ecaidrac ieţneicifusni aiparetotiF
1 lulotipaC
AIPARETOTIF
ECAIDRAC IEŢNEICIFUSNI
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ecinotoidrac roledizoreteh la cigolocamraf luliforP .2 .1 .1
: iimini elii]cnuf etaot \zae]neulfni ecinotoidrac eledizoreteH
tneicifusni i[ lamron iuludracoim a ei]cartnoc ed a]rof cserc
;)v itizop p ortoni tcefe(
; )vitizop por to mtab tce fe( iuludraco im aetatil ibaticxe cserc
: ) v i t i zo p p o r t o n o t t c e f e ( i u l u d r a c o i m a e t a t i c i n o t c s e r c
portomord tcefe( \ralucirtnevoirta erecudnoc ed azetiv dacs
;)vitagen
.)v it agen por tonorc tcefe( \caidrac a ]nevcerf dacs
roledizoreteh aetaticapac nirp \cilpxe es vitizop portoni lutcefE
erac \mizne ,\cimelocras aza-PTA-+K/+aN abihni a ed ecinotoidrac
ed iulutneidarg avirtopm` +aN luxulfe i[ +K luxulfni \rugisa
e c i d r a c o i m e l e l u l e c n ` , i e m i zn e i i r \ b i h n i a e r a m r u a C . e i ] a r t n e c n o c
aeret[erC .edacs +K ai]artnecnoc ec pmit n` et[erc +aN ai]artnecnoc
+2
aC uc +aN a eraot\bmihcs apmop \zaevitca +aN iei]artnecnoc
ai]artnecnoC .ecidracoim elelulec n` +2aC aerednurt\p dniif a]nicesnoc
+2
aC aerarebile ,etrap o ed ep ,\nimreted +2aC a \tucserc \ralulecartni
+2
aC aerednurt\p ,etrap \tla ed ep rai ,cimsalpocras luluciter nid
noriM acnA 6
ecaidrac ieţneicifusni aiparetotiF
noriM acnA 8
ecaidrac ieţneicifusni aiparetotiF
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al brosba es un ,eramru aC
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ecaidrac ieţneicifusni aiparetotiF
abreh sidinodA .7 .1 .1
ela etirolfn` eneir ea eli]r\p \tnizerper
ailimaf nid .L silanrev sinodA ieiceps
\]uc[ur ralupop \timuned ,eaecalucnunaR
.ineblag ie]ided uas \rav\mirp ed
e l e n o z n ` \ t i d n âp s \ r g r a l , a i c e p S
o etse ,ieporuE ela ecitse-dus i[ elartnec
. e l i r e t s i [ e r e f i r o l f in ip l u t u c \ n e r e p \ t n a l p
eliniplut nid tiutitsnoc etse lategev lusudorP
e z n u r f u c , e t a c i f i m a r u a s e lp m i s , e r e f i r o l f
eraoluc ed ,iram irolf i [ etatces-tanep
.eirua-neblag .L silan rev sinodA
noriM acnA 21
ecaidrac ieţneicifusni aiparetotiF
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,i[ ecitamsalp elenietorp ed eraxif ed \suder etaticapac o erA .%73-51
8, 2 ( \tarud \trucs ed etse r ad ,dipar \zaelatsni es as aenui ]ca ,eramru ac
a e r a u n i m i d e d a t a r r a i , e r o 3 2 -3 1 e d e t s e e r i ] \ t \ m u j n ` e d l u p m i T . ) e l i z
ep ,lapicnirp n` ,\nimile es adizoramiC .iz/%93-82 ed etse ii]\tivitca
.\laner elac
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-nirp uinemod ac ,\dnamocer )8891( E ieisimoC aifargonoM
n id et cartxe \zaenoi]idn oc er a c eleta raperp ur tn e p ei] a cidni ed lapic
etse dnâc sela iam ,\rao[u \caidrac a]neicifusni ,abreh sidinodA
.esaov ren ir\rublut ed \ti]osn`
\cigoloib etativitca o era sutamron sivlup abreh sidinodA
.\diz oram ic %2,0 ed tuni]no c iunu erao t\znupseroc
atsaeca nid etuni]bo eletcartxe i[ \tamron aereblup urtneP
al ero 42/\tad o urtnep elezod ,)tacsu uas diulf tcartxe ,\rutcnit(
: tnu s \laro erartsinimda
; g 6,0/g 2,0 : \tamron ereblup
; g 0,6 /g 0 ,2 : )01 :1( \rutcnit
; g 0 ,3/g 0,1 : )5 :1( \rutcnit
*
- \zitrepxe ed tetimoc nu ta]niifn` a ainamreG nid ii]\t\n\S luretsiniM 8791 n`
i[ etnalp ed 003 etsep a a]narugis i[ aetaticacife aulave a urtnep – E aisimoC
.ainamreG n` etazilaicremoc etnalp ed ireicosa
31 eralucsavoidrac inuiţcefa ronu lutnematart iş aixaliforp nî elanicidem eletnalP
ecaidrac ieţneicifusni aiparetotiF
abreh eairallavnoC .8 .1 .1
eneir ea eli]r\p \tnizerper
-noC ieiceps ela etirolfn`
-af nid .L silajam airallav
\timuned ,eaecailiL ailim
uas e r a o i m \ r c \ l ralupop
.ler\tir\gr\m
.L silajam airallavnoC
ed aciremA ,aporuE n` et[erc
.tsev ed aisA i[ droN
-oecnal-lavo eznurf \tnizerP
ei]avren uc ,etanimuca ,etal .L silajam airallavnoC
.laretalinu mecar nu-rtn` etapurg tnus emrofilupuc ,ebla ,elirolf ; \lelarap
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noriM acnA 41
ecaidrac ieţneicifusni aiparetotiF
e d e c i n o t o i d r a c e d i zo r e t e h % 5 , 0 - 1 , 0 e n i ] n o c a b r e h e i r a l l a v n o C
.lox otalavnoc i [ \ dizoxot a lavnoc lapic nirp n` ,cidi lonedrac pit
etse iedizoxotalavnoc a ei]brosba ed atar ,\laro erartsinimda aL
un ecitamsalp elenietorp ed eraxif ed ludarg rai ,%01 iamun ed
-04 uc ecuder es as aetativitca erartsinimda al ed iz o aL .%61 et[e[\ped
.\railib i[ \laner elac ep msinagro nid \nimile es adizoxotalavnoC .%05
es abreh eairallavnoC nid ecinotoidrac roledizoreteh aenui]cA
nid dipar \ nimile es ecin otoidr a c eledizoreteH .tpmo rp \zaelatsni
etaticixot ed rolenemonef a]nesba \cilpxe ec aeec msinagro
a erecudn oc ed lumets is \za etcefa un ,aene mesa eD .\vitalumuc
.enegomtira etcefe ua un ,eramru ac ,i[ iimini lulevin al roliruslupmi
n` \zaertsinimda es abreh eairallavnoC nid eletaraperP
-gniga lumordnis n` i[ eidracidarb uc \taicosa \caidrac a]neicifusni
levin al vitades \zaenoi]cA .)lecud\p ed etcartxe uc ereicosa n`( traeh
.elanoi]cnuf ecaidrac el inui]cefa n` i[ etacidni dniif caidrac
eletaraperp aerazilitu \dnamocer )7891( E ieisimoC aifargonoM
n` ,trofe ed ,\rao[u \caidrac a]neicifusni n` abreh eairallavnoC nid
. c i n o r c r a n o m l u p l u d ro c n ` i [ r o l i c i n t s r â v e l a e c a i d r a c e l i n u i ] c e f a
ii]caer iroerar \caovorp abreh eairallavnoC nid eletaraperP
.)irut\sr\v , \]aerg( er a o[u esrevda
\cigoloib etativitca o era sutamron sivlup abreh eairallavnoC
.\dizoxot a lavn oc %2,0 ed tuni]no c iunu erao t\znupseroc
atsaeca nid etuni]bo eletcartxe i[ \tamron aereblup urtneP
al ero 42/\tad o urtnep elezod ,)tacsu uas diulf tcartxe ,\rutcnit(
: tnu s \laro erartsinimda
; g 6,0/g 2,0 : \tamron ereblup
; g 0,6 /g 0 ,2 : )01 :1( \rutcnit
; g 0 ,3/g 0,1 : )5 :1( \rutcnit
;g 6,0/g 2,0 : )1 :1( diulf tcartxe
.g 51,0/g 50 ,0 : )1 :4( tacsu tcartxe
muilof irdnaelO .9 .1 .1
ieiceps ele znurf \tnizerper
-imaf nid .L rednaelo muireN
\tucsonuc ,eaecanycopA ail
urdnaelo ed aerimuned bus
.urdnael uas
n` et[e rc lurdnaelO
n` i[ ene enaretid e m elenoz
nu etsE .\laciportbus aisA
,etnetsisrep eznurf uc tsubra
, e l i r o l F . e t a lo e c n a l , e c a i r o c
tnus ,5 lupit ep ,zor uas ebla
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.L rednaelo muireN
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noriM acnA 61
ecaidrac ieţneicifusni aiparetotiF
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noriM acnA 02
ecaidrac ieţneicifusni aiparetotiF
ărutpeceR .21 .1 .1
e l a t e g e v r o l e t c a r tx e \ z a i c o s a s o j i a m e d e l a r t s i g a m e l e l u m r o F
elE .evitanimrac uas/i[ e vitades i]\teirporp uc e tcartxe ediolatigid uc
\nigna ,\caidrac \]neicifusni ed erao[u emrof n` etacidni tnus
i[ e inotog a v n` i[ rad ,\z orelcso reta ,\lairetra e nu isnetrep ih ,\larotcep
.)02( dlehmeoR mordnis
noriM acnA 22
ecaidrac ieţneicifusni aiparetotiF
:dlehmeoR lumordnis n~
.pR
g 0,5 ivraC muelO
itnahportS arutcniT
g 0,01 āā eannodalleB arutcniT
g 0,02 aerehtea eanairelaV arutcniT
oitulos .f .M
iz / .cip 03 x 3 , nretni .s .D
:\larotc ep anigna n~
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itnahportS arutcniT
eanairelaV arutcniT
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oitulos .f .M
iz / .cip 02 x 3 , nretni .s .D
.pR
itnahportS arutcniT
eairallavnoC arutcniT
e acim ov sicuN arutcniT
g 0,01 āā eanairelaV arutcniT
oitulos .f .M
iz / .cip 03 x 3 , nretni .s .D
noriM acnA 42
ecaidrac ieţneicifusni aiparetotiF
ăcimihc eițizopmoC .1 .2 .1
l ecud\p ed elirolf i[ ele znurf n id i]alozi i]neu titsnoc iilapicnirP
: )52 ,11( tnus
,\nitnei r o , \ nixetivo zi ,\nixetiv : e cinovalf edizocilg-C
; \dizonm ar-n ixetiv , \nitneiroozi
; icilodinaicotnaorp iremilop
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ecaidrac ieţneicifusni aiparetotiF
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cigolocamraf liforP .2 .2 .1
n ~ . \ l a n i c i d e m \ t n a l p a c \ t ag n u l e d n ` e i r o t s i o e r a l u l e c u d \ P
lutnematart urtnep etazilitu uare elas eletcurf i[ eleznurf IIIX luloces
uaesolof iizenihC .)irut\sr\v ,eeraid( elanitsetniortsag rolii]cnufsid
.eenpsid i[ eimedipilrepih n` ,ieitsegid aeralumits urtnep lulecud\p
urtnep i[ citeruid ac ta zilitu tsof a IIIVX luloces uc dnâpecn~
lutnematart n` as aerazilitu aporuE n~ .ilaner roliluclac aeranimile
tazilitu tsof a 6981 niD .0081 nid \zaetad eralucsavoidrac rolii]cnufsid
.droN ed aciremA n` \ lacidem a citcarp n` i[
eiparet ac sela iam \zaertsinimda es lecud\p ed eletcartxe iz\tsA
\]neicifusni :eralucsavoidrac ii]cnufsid esaoremun n` \vitanretla
.)62( eimedipilrepih i[ \lairetra enuisnetrepih ,\larotcep \nigna ,\caidrac
ed eletcurf i[ e l irolf ,eleznurf nid e ciloocl a ordih etcartxE
iinu i[ ecilodinaicotnaorp ,ecidionovalf inui]carf i[ mucerp ,lecud\p
-7-niloetul ,\dizotur ,\dizorepih ,\nihetacipe( i]alozi irup i]neutitsnoc
a ei]cartnoc ed a]rof cserc ,)cilogetarc dica ,\nixetiv ,\dizoculg
noriM acnA 03
ecaidrac ieţneicifusni aiparetotiF
noriM acnA 23
ecaidrac ieţneicifusni aiparetotiF
noriM acnA 43
ecaidrac ieţneicifusni aiparetotiF
noriM acnA 63
ecaidrac ieţneicifusni aiparetotiF
noriM acnA 83
ecaidrac ieţneicifusni aiparetotiF
arpusa tcefE
\zoD ed laminA / tcartxE
ii]\tilitcartnoc
\tartsinimda \]neirepxe i]neutitsnoC
ecaidrac
urtnep ,aerarut\ln` .v.i gk/gm 11 uc tatarterp( iaboc tcartxE
a ,etunim avetâc gk/gm 55,0
portoni iulutcefe ).v.i lolonarporp
la vitagen
iululolonarporp
iulutcefe aerarut\ln` .v.i gk/gm 4,11 tatarterp( nalobo[ tcartxE
la vitagen portoni gk/gm 9,1 uc
iululimaparev ).v.i limaparev
edionovalF
\vitacifinmes eret[erc .v.i gk/gm 01 tcrafni uc( eniâc lotecrevC
sudorp cidracoim
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a ,\ro o ed pmit
roleretra
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noriM acnA 44
ecaidrac ieţneicifusni aiparetotiF
ăcitueparet nî erazilitU .3 .2 .1
taborpa a E aisimoC ,ecinilc roliiduts roletatluzer azab eP
lutnematart n` lecud\p ed irolf i[ eznurf nid roletaraperp aerazilitu
.)AHYN II asalc( \caidrac \]neicifusni ed erao[u rolemrof
noriM acnA 64
ecaidrac ieţneicifusni aiparetotiF
.pR
igeatarC serolF
igeatarC muiloF
g 0,001 da ā ā eassileM muiloF
s eiceps .f .M
nretni .s .D
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g 0,001 da ā ā sepits ibla icsiV
s eiceps .f .M
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esrevda iițcaeR .4 .2 .1
enib ,lareneg n` ,tsof ua lecud\p nid eletaraperp ecinilc iiduts n~
.etarelot
,i]neicap ed etalanmes esrevda eletcefe et[evirp ec aeec n~
i[ \nergim ,\]aerg ,elaom nuacs n` tatsnoc ua i[ erar tsof ua aetseca
ua erac roli]neicap lur\mun ,bro-ulbud uiduts nu-rtn~ .ii]atiplap
timirp a erac lupurg n` eram iam tsof a esrevda ii]caer talanmes
. ) 7 . g i f ( l e cu d \ p e d t c a r t x e u c t a t a r t l u p u r g n ` t â c e d o b e c a l p
noriM acnA 05
ecaidrac ieţneicifusni aiparetotiF
esaotnemacidem inuițcaretnI .5 .2 .1
inu i]caretni eleli b isop ,e taraperpotif r otla lu zac n` i[ aC
ed tneicifus tsof ua un lecud\p ed roletaraperp ela esaotnemacidem
e tatilai ceps ed arutareti l iro etlum iam elec ed i[eD .etaiduts enib
15 eralucsavoidrac inuiţcefa ronu lutnematart iş aixaliforp nî elanicidem eletnalP
ecaidrac ieţneicifusni aiparetotiF
iițacidniartnoc iș iițuacerP .6 .2 .1
ep e r onim elirucs ir \zai] nedive IIV .b a t n` et a tnezerp eletaD
u c a i p a r e t e d \ ] a f l e cu d \ p e d e t c a r t x e u c a i p a r e t \ c i l p m i e l e r a c
.)01( ec inotoid rac edizoreteh
i e m e f a l l e c u d \ p e d r o l e t a r ap e r p a e r a r t s i n i m d a , a e t s e c a e t a o t u C
iubert ra ina 21 bus iiipoc al i[ mucerp ,\zaetp\la erac i[ etanicr\sn`
.\tative
uc roli]neicap etacidniartnoc tnus lecud\p ed eletaraperP
ii] neut itsnoc ertnid lunu al icigre la tnus erac u a s etatili bisnesrepih
.)62( iulusudorp
noriM acnA 25
ecaidrac ieţneicifusni aiparetotiF
: EIFARGOILBIB
noriM acnA 45
ecaidrac ieţneicifusni aiparetotiF
J mA .sesu cituepareht dna ygolocamrahp :nrohtwaH .VB teewS ,MJ ykslegiR .62
.124-714 :95 ;2002 mrahP tsyS-htlaeH
eralukelom dnu erälulleZ .GHR regniwhcS ,S smlliW ,K suixirB .72
:)1( 43 ;5002 tieZ reresnU .mrahP .tkartxE-sugeatarC nov nemsinahcemkriW
.05-84
misarehG ai]cader bus( \nretni \nicideM :nI .\caidrac a]neicifusnI .II renkcurB .82
.772-512 ,4002 ,\lacideM .dE :it[erucuB .)II .lov ;.L
stcartxE laicepS sugeatarC htiw stluser lacinilc dna lacigolocamrahP .D weoL .92
.52-02 :6 ;4991 margeletotyhP naeporuE .ycneiciffusni caidrac ni
nov negnukriW-fualsierK-zreH .sugeatarC .R luaK ,TPH nommA .03
sad fua negnukriW :2 lieT .nenidinaycorP dnu nedionovalF ,netkartxesugeatarC
.5352-1252 :)72( 431 ;4991 .gtZ .htopA .hcstD .zreH
nosirapmoc ni 2441 SW tcartxe sugeatarC fo ytefas dna ycaciffE .M trehcuaT .13
-ssalc noitaicossA traeH kroY weN elbats cinorhc htiw stneitap ni obecalp htiw
.519-019 :)5( 341 ;2002 lanruoJ traeH naciremA .eruliaf traeh III
nrohtwaH eht fo ycaciffE .D-W renbüH ,M hcolP ,U nhuK ,U tdimhcS .23
traeh evitsegnoc cinorhc htiw stneitap 87 ni 231 IL noitaraperP )sugeatarC(
.42-71 :1 ;4991 enicidemotyhP .II ssalc lanoitcnuf AHYN sa denifed eruliaf
traeh evitsegnoc ni 2441 ®SW tcartxe sugeatarC fo ycaciffe lacinilC .G efpaZ .33
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fo sisylana-atem :eruliaf traeh cinorhc gnitaert rof tcartxe nrohtwaH .HM relttiP .43
.376-566 :411 ;3002 enicideM fo lanruoJ naciremA ehT .slairt dezimodnar
2 lulotipaC
AIPARETOTIF
ECIMEHCSI IEITAPOIDRAC
noriM acnA 65
ecimehcsi ieitapoidrac aiparetotiF
cigolocamraf liforP .1 .1 .2
ed eletcartxe \c lutpaf tai]nedive ua oviv ni i[ ortiv ni iidutS
aizufrep cserc ,eramru ac ,i[ nairanoroc niugnas luxulf cserc lecud\p
.)01-6( \cidracoim
)2IGP( \nilcicatsorp ed azetnis \zaelumits lecud\p ed eletcartxE
eramrof uc azalciclineda \zaelumits 2IGP ; elailetodne elelulec ert\c ed
.)cPMA( cilcic tafsofonom nizoneda ed
,ei]atalidosav ecudorp es ,cPMA ed iir\lumuca a eramru aC
\ r a l u c s a v a ] n e t s i z e r e cu d e r e s i [ n a i r a n o r o c n i u g n a s l u x u l f e t [ e r c
n ` i a m u n u n l e cu d \ p e d r o l e t c a r t x e a ] n e i c i f e \ c i f i t s u j e c a e e c \ c i r e f i r e p
.)41 – 9( elairetra iinuisnetrepih la i[ ic ,elarotcep ienigna lutnematart
tnus etcefe ets eca e d eraot\znups \r evit ca eliipicnirP
,anixetiv ,adizotur ,adizorepih ,adizoculg-O-niloetul( eledionovalf
-inaicotnaorp i[ )adizonmar-nixetiv-litecaonom ,adizonmar-nixetiv
.)01-6( )eznurf nid i]alozi iiremid sela iam ,iiremogilo( iilod
top pmit n` erac ieimehcsi lupmit nid iuludracoim elinuizeL
iuluserts ,lapicnirp n` ,etarotad tnus \caidrac \]neicifusni areneg
a \vitadixo aeradargeD .elifortuen nid iezatsale iir\rebile i[ vitadixo
elii ]aps nid ienitsale a zilordih i[ mucerp ,eralu lec rolirutcurts
al eralusit i regurtsid \ni mreted iezatsale aenu i]ca bu s eralulecartxe
i[ eledionovalF .elitcartnoc iei]cnuf aeratcefa uc iuludracoim lulevin
lecud\p ed elirolf i[ eleznurf nid icilodinaicotnaorp iiremogilo
iiremogilo ,sulp n~ .iulunegixo ela evitcaer eliiceps \zaevitcani
.)61 ,51( iezatsale aetativitca \b ihn i icilod inaicotnaorp
e r a z e l e d i u l u d a r g a e r e i c e rp a u r t n e p i ] a z i l i t u i i r t e m a r a p n i d l u n U
\mizne ,)HDL( iezanegordihed-tatcal la cires lulevin etse \cidracoim
dimanitocin ed \]nezerp n` civurip dica n` citcal ludica \mrofsnart erac
ed ecir e s rol e levin aeraz o D .)H DAN( suder d i toelcunid – nineda –
,cidracoim iulutcrafni lucitsongaid urtnep tâta cinilc \tazilitu etse HDL
. c i d r a c o i m lu t c r a f n i n ` iu lu t n e m a t a r t i i ] \ t i c a c i f e a e r e i c e r p a u r t n e p i [ t â c
-arbmem aetatilibaemrep ,ecidracoim inuizel ienu elii]idnoc n~
lui]aps n` cert HDL ed etucserc elevin i[ et[erc roleticoimoidrac a \ran
noriM acnA 26
ecimehcsi ieitapoidrac aiparetotiF
noriM acnA 46
ecimehcsi ieitapoidrac aiparetotiF
iuluxulf aeret[erC
niugnas \tazilitu \zoD i]neutitsnoC / tcartxE
nairanoroc
*%1,07 lm/gμ 001 sopa uudizeR
edionovalF
*%8,12 lm/gμ 05 1 aenui]carF
*%5,36 lm/gμ 001 2 aenui]carF
%681 l/lomm 5,0 adizoculg − 7 − niloetuL
%201 l/lomm 5,0 adizorepiH
%84 l/lomm 5,0 adizotuR
ilodinaicotnaorP/inavalF
%05 lm 3,0 \nihetacipE
%34 nid lm 51,0 iremogilo ed tartnecnoC
%5,0 ai]ulos
5,4 urtnep
.nim
%78 nid lm 51,0 ed tacidir darg uc iremogilO
%5,0 ai]ulos eraziremilop
5,4 urtnep
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%131 nid lm 51,0 ed tuz\cs darg uc iremogilO
%5,0 ai]ulos eraziremilop
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*%95 lm/gμ 01 2 aenui]carF
\tnatsnoc enuiserp uc erazufrep *
noriM acnA 66
ecimehcsi ieitapoidrac aiparetotiF
aeret[erC
ataruD iuluxulf \zoD ed laminA / tcartxE
iulutcefe niugnas \tartsinimda \]neirepxe i]neutitsnoC
nairanoroc
- 1 \pud gk/lm 1 – 5,0 eniâc nid sopa tcartxE
al ed .nim nairanorocartni )taizetsena( i[ irolf uc eznurf
851 al 131 etcurf
.nim/lm
01 – 7 %072-09 50,0 – 5210,0 eniâc ciloocla tcartxE
.nim gk/gm )taizetsena( i[ \]neinevorp(
nairanorocartni - ei]izopmoc
)etazicerpen
1 .xorpa %93-52 iz/g 4,1-5,0 x 1 \r\f( eniâc ciloocla tcartxE
h laro )eizetsena irolf uc eznurf nid
-1 .xorpa %82-52 iz/g 4,2-5,1 x 1 etcurf i[
h2 laro
ilodinaicotnaorP
avetâc %07 07 – 02 x 3 \r\f( eniâc iremogilO
ero cinliz gk/gm )eizetsena icilodinaicotnaorp
laro
ăcitueparet nî erazilitU .2 .1 .2
n` rol e ticoimoidr a c a ei]ceto r p ed ,eraot at alidorano roc eletcefE
e d i [ m u c e r p , e c i m e h c s i ro l i n u i z e l a e r e c u d e r e d , e i m e h c s i e d i i ] i d n o c
noriM acnA 86
ecimehcsi ieitapoidrac aiparetotiF
solf eacinrA .2 .2
acinrA ieiceps ele]necserolfni \tnizerper
-uned ,eaecaretsA ailimaf nid .L anatnom
.rolenâz lurac uas \cinra ralupop \tim
-ipil \niplut o \tnizerp aicepS
.em i]l\n` mc 0 3-02 ed \saor\p-soic
-rtn` esupsid tnu s rolezn urf aetatirojaM
nu etse a]necserolfnI .\ralizab \tezor o
ed etalugil irolf nid tiuti tsnoc uiditalac
- r e h i r o l f i [ e i l a co t r o p - n eb l a g e r a o l u c .L anatnom acinrA
.)22 ,12 ,02( iilacotrop ,esaolubut ,etidorfam
ăcimihc eițizopmoC .1 .2 .2
pit ed ecinepretivcses enotcal %8,0-2,0 eni]noc lategev lusudorP
iiretse i[ \nilanelehordihid – 31 ,α11 ,\nilaneleh( cidilonaiaugoduesp
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cigolocamraf liforP .2 .2 .2
.\lanoi ]idart anicid em n` etazil itu tlum ts of ua \cin r a ed elirolF
n ` \ c i n r a e d r o l i r o l f a e r a z i l i t u \ z a e n o i ] n e m IV X l u l o c e s n i d i r e i r c S
ela enegidni irimuned etluM .emaotameh i[ irutcarf ,ii]axul ,in\r
ir \zilitu etseca \zaereg us ,\daoirep aeca nid \zaetad erac ,ietnalp
,) \rutpur = kaerb( breh kaerb ,) ered\c = llaf( breh llaf :ecitueparet
ua \cinra ed elirolf eraot\mru eleloces n~ .)\nar = dnuow( breh dnuow
,msitamuer ,mtsa ,elaurtsnem irerud ,elirbef ir\ts n` etartsinimda tsof
a at nalp ir\zilitu rolesaor em un \tirotaD .eralucs av i[ ecaidrac inui]cefa
.murospal aecanaP \timuned tsof
noriM acnA 07
ecimehcsi ieitapoidrac aiparetotiF
e r a o t i r e f e r i i ] a m ro f n i e l e m i r p i [ \ z a e t a d e t u c e r t e l e l o c e s n i d t o T
a iram ezod n` \nretni aerartsinimda \pud etur\pa esrevda elii]caer al
nid dnâtad ir\nmesn` \tsixE .\cinra ed irolf nid iirutcnit i[ ieizufni
ed rolirolf i ir\zilitu ii]\tis ecen arpusa ai]neta g a rta erac IIIVX luloces
.roli cidem aeradn am ocer al iamun \cinra
nid eletcartxe \c tidevod ua ecinilc i[ oviv ni ,ortiv ni iidutS
: e cig olocamraf etcefe ed e nidutitlum o \ tlovze d solf eacinrA
-usxeitna ,ecizeglana ,eraotamalfniitna ,ecignufitna ,eneiretcabitna
,iirotaripser citpelana ,eraotavitcaoigna i[ eraotavitcaoidrac ,evitad
ela ecigolocamraf etcefe elesaoremuN .eciteruid ,egogaloc ,ecicotico
,p mit i[alec a n` ,rad ecitu eparet elir\zil itu \cifits uj \cin ra ed roletcartxe
ii]\ tivit celes aspiL .enui]ca ed ii] \tivitceles iesp il a \ralc adavod tnus
rolii]caer aetatireves i[ aenidutitlum \tadotot \cilpxe enui]ca ed
.)tcatnoc ed \titamred ,etaticixotoidrac ,\tiretneortsag( esrevda
-aperp ela esrevda elii]caer i[ tâc ,ecigolocamraf eletcefe tâtA
.ecinepretivcses rolenotcal ,lapicnirp n` ,etarotad tnus \cinra ed roletar
linobrac irutcurts( etarutasen-β,α elarutcurts etnemele ni]noc aetsecA
-β,α o ,\notcal-γ-nelitem-α o-rtnid etrap caf erac etarutasen-β,α
.)\tagujnoc retse pit ed \rutcurts o uas \tiutitsbusen \nonetnepolcic
*
leahciM irotpecca ac \zaenoi]ca etarutasen-β,α elarutcurts eletnemelE
ela lirdihflus elir\purg tnus muc ecigoloib elifoelcun irutcurts ed \]af
ed aenidutitlum leftsa dnânimreted eralulec rolenietorp i[ rolemizne
.)42( )11 .gif( roiretna etanoi]nem ecigolocamraf etcefe
aec if a tidevod a-s anilaneleh ,ecinepretivcses elenotcal ertniD
.\vitca iam
ia i]nalihcla iirtnec \c lutpaf tai]nedive ua ortiv ni iidutS
,ulp mexe eD .ecietorp eliru tcurts lai]nerefe rp \gael ienilaneleh
aerapurg ed anietsic rai ,\nonetnepolcic ed tagel etse lunoitatulg
ed \]af \tirefid etativitcaer \tsaecA .ienotcal-γ a \cinelitemoxe
,ec igolo ib etce fe ed gr a l lurt ceps \ cilpxe \tn i] ecietorp elirutcurts
ae r artsinim da al rapa er a c esrev da etcefe ed a enid utitlum i[ mucerp
.)42 ( \cinra ed roletaraperp
H
+
δ
O
-
-O
O
δ δ
O
H
δ
+
R
S
H
H
S
R
H
S
R
H
O
O
O
O
O
H
O
O
H
R
S
R
S
O
H
noriM acnA 27
ecimehcsi ieitapoidrac aiparetotiF
ăcitueparet nî erazilitU .3 .2 .2
: ed \mrof bu s azilitu eta op e s lategev lusudorP
e]i rugnil \uod etsep ereb r eif al \pa ed \nac o \g uada e s – e izufni −
\uod cinliz \dnamocer eS .etunim 01 \pud \zaertlif es ; lategev sudorp
ez e r tsinimda es \s eiubert a izufni ; \taraperp t\ p saorp eizufni ed in\c
.erar iru ti]ihgn` uc
u a s \ d l a c \ p a \n i ] u p n ` e t a u l i d \ ] n i r e f e r p e d , i z / . c i p 0 1 – 5 − \ r u t c n i t −
et un im 51 ed pmit n` aeb es \s er ac \]udl\c \pa u c rahap nu -rtn` .cip 05
.icim iruti]ihgn` uc
aenuiger n` lacol a cilpa top es \cinra ed e let c artxe ,aenemesa eD
.)91 ,6( )®ROCOTCEP( iimini
esrevda iițcaeR .4 .2 .2
\cinra ed roletcartxe a iram ezod n` \nretni aerartsinimda aL
,i rut\sr\v ,\]aerg :erev es esrevda ii]caer rapa ) \rutcnit ,eizufni(
e c aidrac ii]cnufsid ,elau rt snem ir\regnâs ,rome rt ,jitrev , \ tiretneortsag
ni rp et r aom enimreted \ s rai hc top iram etraof elezoD . iirotaripser i[
.caidrac pots
nid eletcartxe \tarud ed i[ \tnevcerf \nretxe erartsinimda aL
*
tcatnoc ed \titamred i[ elacol ii]atiri cudorp \cinra ed irolf
. )5 2 , 4 2 , 7 , 6 ( e l u c i z e v i c i m e d a e r a m r o f n i r p \ t a z i r e t c a r a c
noriM acnA 47
ecimehcsi ieitapoidrac aiparetotiF
ăcimihc eițizopmoC .1 .3 .2
- orconaruf eni ]n oc lateg e v lusudorP
eniramuconarip ,)anigansiv ,anilek( enom
i[ edipil ,litalov ielu ,edionovalf ,)anidansiv( ).L( agansiv immA
.) 52 ,12 , 02( enietorp .maL
O
C
H
O
3
O
O
H
C
O
C
O
3
H
C
O
3
O
R
O
C
R O H
H
C
a
n
i
l
e
K
3
a
n
i
g
a
n
s
i
v
a
n
i
d
a
n
s
i
v
cigolocamraf liforP .2 .3 .2
r o t a t a l i d o s a v \ z a e n o i ] c a s utcurf eagansiv i mmA n i d e l e t c a r t x E
dniif \deten arutalucsum \zaexaler i[ cirefirep i[ nairanoroc levin al
es aonigna itna ac ebara ir \] etlum n id \lanoi]ida r t anicidem n` etazilitu
tnus etcefe etseca ed eraot\znups\r evitca eliipicnirP .ecitilomsaps i[
.anidansiv i[ anigansiv ,anilek
ăcitueparet nî erazilitU .3 .3 .2
r onu a i]izopmoc n` \rt ni sut c urf eagan siv i mmA n i d e t c a r t x E
:elarotcep ienigna lutnematart n` etazilitu ereicosa ed etaraperp
®NAGNALLEHK ,S ®LATURSEA ,N ALLEHK-®TNACAXO
.)91( ®NEBUDRAC ,®TARCONETS ,N
esrevda iițcaeR .4 .3 .2
nid eletaraperp ,\tagnuledn` erartsinimda al uas erazodarpus aL
,einmosni ,\]netepani ,ei]apitsnoc ,jitrev cudorp sutcurf eagansiv immA
,libisrever citatseloc retci( \citapeh eratcefa ,)tirurp( ecigrela ii]caer
. ) 3 2 ,7 ( ) e c i t a p e h r o l e z a n i m a s n a r t l a t u c s e r c l e v i n
noriM acnA 87
ecimehcsi ieitapoidrac aiparetotiF
a
n
i
p
o
c
i
l
.edipil n` \vlozid es ,bmihcs n` ;\pa n` \libulosni etse anipociL
t ropa n u \c lutp a f ta i]nedive ua etnecer ecigo loimedi pe iidutS
i [ e n g i l a m ro l i n u i ] c e f a a ] n e d i c n i e c u d e r \ n i p o c i l e d t u c s e r c r a t n e m i l a
,anipocil azitetnis etaop un namu lumsinagro muC .eralucsavoidrac
.d i onetorac tseca nid et neicifus i]\titnac ezez i nruf \s eiubert ateid
ed uerg ed lutsed ,gm 53 ed etse \nipocil ed tadnamocer cinliz lutropA
ed nu ,AU S n` \c \za ic erpa eS .\tiun[ibo \teid o-r tnirp tazilaer
uidem lutropa ,tucserc etse etamot nid etasecorp esudorp ed lumusnoc
.iz/gm 5 iamun ed etse ainamreG n` ec pmit n` iz/gm 52 ed etse
- i b i n o p s i d o i b , t â t a t â c e d t lu m i a m , i [ \ l i b a t s o m r e t e t s e a n i p o c i L
etamot n~ .\cimret erarculerp nirp et[erc ,iulunetorac-β a i[ ac ,as aetatil
es un enietorp-\nipocil luxelpmoC .enietorp ed \tagel etse anipocil
dlac aL .iram eralucelom ii]\tuerg \tirotad lanitsetni levin al ebraosba
etatuerg o dnâva ,erac anipocil \zaerebile i[ \zaicosid xelpmoc tseca
.elanitsetni roli]\tizoliv lulevin al ebraosba es ,\cim \ralucelom
-sic al lai]rap \zaeziremozi anipocil-snart ,erizl\cn` nirp ,\tadotoT
.snart luremozi tâced eram iam etatilibinopsidoib o era erac \nipocil
,ii[or ed \tsap ,ii[or ed cus( ii[or nid etasecorp elesudorP
.edurc elii[or uc vitarapmoc \nipocil ed enub iam esrus tnus )puhctek
noriM acnA 08
ecimehcsi ieitapoidrac aiparetotiF
1
2
H
O
c
i
n
e
l
o
n
i
l
a
f
l
a
d
i
c
a
-α dica n` etagob elategev elesrus nid anu \tnizerper nemes iniL
.bat n` etatnezerp tnus cinelonil-α dica ed elategev esrus etlA .cinelonil
.)13( IIX
noriM acnA 28
ecimehcsi ieitapoidrac aiparetotiF
t r o p a n u e z e z i n ru f \ s e i u b e r t a t e i d \ c l u t p a f t a n o i ] n e m e i u b e r T
elategev esrus elelapicnirP .6-ω i[ 3-ω ilai]nese i[arg izica ed tarbilihce
eletnalp tnus )cinelonil-γ dica ,cielonil dica( 6-ω i[arg izica ed
.elelaerec i[ esaonigaelo
tseca nid \tarbilihcezed etraof etse \latnedicco ateid tnezerp n~
: 03-02 ed 3-ω : 6-ω tropar nu-rtnirp es-udnâziretcarac eredev ed tcnup
tropar nu tirod ed etse \c \zaicerpa iit[inoi]irtun erac n` elii]idnoc n` 1
n` \car\s i[ 6-ω i[arg izica n` \tagob \teid O .1 : 1 raihc uas 1 : 3 ed
inui]cefa ,eralucsavoidrac ilob al enupsiderp 3-ω i[arg izica
.)13 ,52( iigrela i[ tebaid ,iirotamalfni
: EIFARGOILBIB
noriM acnA 48
ecimehcsi ieitapoidrac aiparetotiF
noriM acnA 68
ecaidrac roliimtira aiparetotiF
3 lulotipaC
AIPARETOTIF
ECAIDRAC ROLIIMTIRA
noriM acnA 88
ecaidrac roliimtira aiparetotiF
noriM acnA 09
ecaidrac roliimtira aiparetotiF
.)5 ,3 ( )mezaitlid
\zaenoi]ca abreh iirapocs inmahtoraS nid eletcartxE
.I asalc nid rolecimtiraitna rot\n\mesa
ăcimihc eițizopmoC .1 .1 .3
uelcun uc iziol a cla %8,0 etsep eni] noc lat egev lusudorP
,ciefac iuludica ia i]avired ,enovalfozi ,enovalf ,cinidizilonihc
-( ed i]atnezerper tnus icinidizilonihc iiziolaclA .litalov ielu ,eniramuc
.)8 ,7( \nirdnedoma ,\ninapul ,\nietrapsoxo-71 ,\nietraps-)
H
N
N
N
N
H
H
O
a
n
i
e
t
r
a
p
s
a
n
i
n
a
p
u
l
cigolocamraf liforP .2 .1 .3
iirapocs inmahtoraS nid roletcartxe a \cimtiraitna aenui]cA
: n i r p c i m t i r a i t n a \ z a e n o i ] c a a n i e t r a p S . i e n i e t r a p s \ t a r o t a d e t s e abreh
ed azaf n` iezetiv aerecuder uc +aN ed rolelanac aeracolb –
;)0 azaf ( eraziraloped
+
ed iulusecorp atarud et[erc ,eramru ac ; K ed rolelanac aeracolb –
iululai]netop ietarud aeret[erc \nimreted ec aeec 2 azaf nid eraziraloper
.eratcarfer i ed aoirep a i[ enui]ca ed
iiduts nirp etai]nedive tsof ua ienietraps ela ecimtiraitna eletcefE
ed iululai]netop atarud tignulerp a anietraps ortiv nI .oviv ni i[ ortiv ni
iululai]netop a eret[erc ed atar i[ erecudnoc ed azetiv tuz\cs a ,enui]ca
ie i]ali r bif i[ ieidracihat a]nedicni suder a o v i v n i ; enui]ca ed
.)\tacovorp eimehcsi nirp i[ \nitinoca ed esudni( eralucirtnev
.iuludracoim lulevin al \cificeps enui]ca o \tlovzed anietrapS
tâc u rtn` \licifid etse ro lecimtira itna a I asa lc n` ie aerasalcbuS
asalc nid cimtiraitna( ieniacodil rot\n\mesa +aN ed elelanac \zaehcolb
noriM acnA 29
ecaidrac roliimtira aiparetotiF
ăcitueparet nî erazilitU .3 .1 .3
inmahtoraS nid roletaraperp aetaticacife \c \redisnoc E aisimoC
iretabzed \pud ,eramru ac ,i[ \tidevod tneicifus etse un abreh iirapocs
.lategev lusudorp vitagen taulave a ,etasrevortnoc i[ ignul
\lapicnirp aenui]ca \c \zaenoi]nem )8( )4991( lthciW ec pmit n~
aeraroilema \tnizerper o abreh iirapocs inmahtoraS nid roletcartxe a
\c \redisnoc )01( )0002( nnamletniF i[ ssieW ,iirotalucric rolii]cnufsid
.ecaidrac rolecimtiraitna airogetac n` esulcni eiubert etcartxe etseca
if top ,ecitueparet ezod n` \tarud ed erartsinimda al etarelot enib dniiF
elanoi]cnuf eliimtira tnus muc erao[u roliimtira lutnematart n` etazilitu
.enuisnetopih erps \]nidnet uc ieidracihat lupit ed eramirp
esao pa etcartxe e d \ mrof bu s azilitu eta op e s lategev lusudorP
e S . \ p a u c \ n a c o a l l a t e g e v s u d o r p \ ru g n i l o / \ ] i r u g n i l o - r t n i d e t a r a p e r p
.)01 ,8 ,7( iz/in\c 4 – 3 a aerartsinimda \dnamocer
a]nenopmoc n` \rtni abreh iirapocs inmahtoraS nid tcartxe nU
.)11( ®LOITRAPS iulutaraperp
esrevda iițcaeR .4 .1 .3
n` etacidniartnoc tnus abreh iirapocs inmahtoraS nid eletcartxE
.)8 ,7( )divarg iuluretu aetaticinot cserc( \nicras i[ \lairetra enuisnetrepih
.pR
g 0,03 iimesleG arutcniT
i z / .cip 03 - 02 x 4 - 2 , nretni .s .D
.pR
g 0,01 iimesleG arutcniT
g 0,03 da aerehtea eanairelaV arutcniT
oitulos .f .M
iz / .cip 03 – 02 x 3 ,nretni .s .D
.pR
g 0,5 iimesleG arutcniT
g 0,01 mudiulf sidinodA mutcartxE
g 0,03 da eanairelaV arutcniT
oitulos .f .M
iz / .cip 04 - 02 x 3 , nretni .s .D
.pR
g 0,21 iimesleG arutcniT
g 0,03 da mudiulf igeatarC mutcartxE
oitulos .f .M
iz / .cip 02 x 3 , nretni .s .D
noriM acnA 49
ecaidrac roliimtira aiparetotiF
: EIFARGOILBIB
.5991 ,nizideM rüf galreV rotnaC oitidE : .ttrüW/frodneluA .etsiL etoR *** .11
:revodnA .stnalp lanicideM ,yrtsimehcotyhP ,ysongocamrahP .J notenurB .21
.5991 ,dtL tpecretnI
etnalP :nI .\nizil al ed i]avired iziolaclA .U ucsen\tS ,E ucserogirG ,I ieluiC .31
,II .lov ,3991 ,\lacideM .dE :it[erucuB .eiparetotif i[ eimihcotif ,elanicidem
.514-893
sugeatarC fo tceffe evitcetorP .R bocaJ ,K zteiD ,H nadiewS ,S issedkaM lA .41
eht ni aimehcsi wolf-on labolg retfa saimhtyhrra noisufreper tsniaga ahtnacayxo
.77-17 :49 ;9991 loidraC seR cisaB .traeh tar
ni stnerruc muissatop skcolb tcartxe sugeatarC .W sualK ,W ekniL ,A rellüM .51
.933-533 :56 ;9991 acideM atnalP .setycoym caidrac ralucirtnev gip aeniug
noriM acnA 69
elairetra iinuisnetrepih aiparetotiF
4 lulotipaC
AIPARETOTIF
ELAIRETRA IINUISNETREPIH
. ) 6 ,5 ,4 ,1( e i]atalidosav
eaiflowuaR :etazilitu tnus elairetra iinuisnetrepih aiparetotif n~
,erolf muc muilof igeatarC ,sublub ivitas iillA ,abreh icsiV ,xidar
.muilof irdnedodohR ,muilof eaelO
xidar eaiflowuaR .1 .4
nid htneB anitnepres aiflowuaR ieiceps elinic\d\r \tnizerper
.eaecanycopA ailimaf
ăcimihc eițizopmoC .1 .1 .4
,enizer ,icilodni iziolacla %1 etsep eni]noc xidar eaiflowuaR
icilodni roliziolacla aetatirojaM .ilorets ,enovalf ,enonihcartnalitemixo
es ait[eca ertnid ; ralucsavoidrac iulutarapa lulevin al \zaenoi]ca
.)01( anilamja i[ )anizabuar( anicilamja ,aniprezer \cramer
N
NH
O
C
H
3
H
C
O
3
H
C
O
C
O
O
C
O
O
C
H
3
3
H
C
O
3
H
C
O
3
a
n
i
p
r
e
z
e
r
NH
H
O
N C
O
H
C
C
O
O
C
H
3
3
a
n
i
l
a
m
j
a
a
n
i
c
i
l
a
m
j
a
cigolocamraf liforP .2 .1 .4
anicidem n` etatihcitnA nid \cn` \tazilitu etse xidar eaiflowuaR
n` ,etcesni ed uas epra[ ed elirut\c[um n` toditna ac \naidni \lanoi]idart
.elanimodba irerud ,elirbef ir\ts ,etateixna i[ etatilibaticxe ,energim
evisnetrepihitna elemirp tsof ua xidar eaiflowuaR nid eletcartxE
tsof ua arotseca ela evisnetrepihitna eletcefE .\citueparet n` etazilitu
n ` , u i z r â t i a m i n a e t p a { . a rp o h C e r t \ c e d 3 3 9 1 n ` o v i v n i e t a i ] n e d i v e
. )11 ,3( \ cinilc anicid em n` sudo rtni a-el lik a V na idni luc idem ,0491
xidar eaiflowuaR nid roletcartxe a \visnetrepihitna aenui]cA
ep enui]ca uc citilocita pmisoruen nu – ien iprezer \tarotad etse
ed lulibinopsid edacs aniprezeR .ranoilgnagtsop citapmis lunoruen
aerabihni nirp iranoilgnagtsop icitapmis iinoruen nid \nirfeniperon
tiz op ed ed elelucizev n` ci tpanis lui]aps n id aietse ca iir\tpacer
\nimreted ec aeec edacs citapmis lusunot ,eramru aC .elanoruen
aerecuder ,\]nicesnoc n` ,i[ ecirefirep eralucsav ie]netsizer aerecuder
.)6 ,1( eniugnas iinuiserp
etcartxe csesolof es elairetra iinuisnetrepih aiparetotif n~
elac ep \zaertsinimda es aetsecA .xidar eaiflowuaR nid etazidradnats
cidiolacla latot gm 6 ed etse \tadnamocer \cinliz azod ;\laro
iam ezod n` \zaertsinimda es eletcartxe lai]inI .ezirp 3 n` \tazitraper
a e r e d \ c s o \ z a e r t s i g e rn ` e s \ n â p t a t p e r t c s e r c e s i o p a e r a c i c i m
ed pmi t \vit ca azod uc io pa \unitn oc es lutnem a tarT .elairetra iinuisnet
ronu iei]irapa luzac n` iamun ecuder es azod ;na nu al \nâp inul 3-2
3-2 \pud tnel \zaelatsni es visnetrepihitna lutcefE .esrevda etcefe
\pud inâm\tp\s avetâc \tsisrep i[ erartsinimda ed inâm\tp\s
.iul u tnemata r t aerepurertn`
xidar eaiflowuaR nid roletcartxe a \visnetrepihitna aenui]cA
a eramru ac \vitades en ui]ca o ed cifeneb do m n` \tatelpmoc etse
.lartn e c l evin al e nimalocetac ed roletizop ed iei]elped
ăcitueparet nî erazilitU .3 .1 .4
n` \rtni xidar eaiflowuaR nid etazidradnats etcartxE
ETRA : evisnetrepihitna etcefe uc etaraperp roleraot\mru a]nenopmoc
N ®NOTCNUFUAR ,®TNALPOWUAR ,S ETROF ®NITUAR
.)21(
esrevda iițcaeR .4 .1 .4
xidar eaiflowuaR nid eletcartxe \tagnuledn` erartsinimda aL
.eiserped ,\]netopmi ,\]nelonmos ,\lazan eitsegnoc cudorp
xidar eaiflowuaR nid roletcartxe aerartsinimda \tacidniartnoc etsE
aereicosa i[ mucerp ,eratp\la i[ \nicras ,reclu ,moticomorcoef ,eiserped n`
eidracidarb \nimreted( ecilatigid ,)iepodovel lutcefe cuder( apodovel uc
.)11( )CNS cinretup \mirped( ecirutibrab i[ ecitpeloruen ,)\reves
abreh icsiV .2 .4
e d etatlocer etcurf i [ eznurf ed eti]osn` e r enit elir umar \tnizerper
ralupop \timuned ,eaecacsiV ailimaf nid .L mubla mucsiV aiceps al
.csâv
301 eralucsavoidrac inuiţcefa ronu lutnematart iş aixaliforp nî elanicidem eletnalP
elairetra iinuisnetrepih aiparetotiF
ăcimihc eițizopmoC .1 .2 .4
erac \ xelpmoc \c imi hc ei]i z opmoc o era lategev lusudorP
.iir\tlocer lutnemom i[ \tatizarap adzag ed tnedneped \zairav
:tnus abreh icsiV iulusudorp ia i]neutitsnoc iilapicnirP
; )nitkelletsiM = LM( III LM ,II LM ,I LM : elenitcel
; elenixotocsiv
i[ irumar n`( tacifiretse cinretup nanorutcalag : eledirahazilop
; )etcu rf n`( dica n a tcalagon ibara ,)eznurf
H
C
O
H
C
O
3
3
H
O
l
G
O
'3
'3
'4
'4
O
C
H
O
O
C
H
3
3
7
7
5
5
l
G
O
H
O
O
H
O
a
z
o
c
u
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,etar oloc ,erematnep irolf i[ nretla esupsid
l utcurF .emecar n` e tapurg , etalunapmac
ed e]n imes esaorem un uc \luspac o etse
.)4 1( icim i nuisnemid .ps nordnedodohR
ăcimihc eițizopmoC .1 .6 .4
ia i]neutitsnoc iilapicnirP
H
O
. ecilonef eled
H
O
l
o
d
e
m
o
r
d
n
a
l
i
t
e
c
a
.)41 ,01(
cigolocamraf liforP .2 .6 .4
\tarotad etse lategev iulusudorp a \visnetrepihitna aenui]cA
bus i[ tucsonuc ,iululodemordnaliteca laiceps n` ,rolenixotonayarg
i[ I anixotonayarg ,\nixotobesa ,\nixotodemordna ed elirimuned
.\nixotodohr
cserc i[ +aN ed rolelanac lulevin al \zaexif es elenixotonayarG
xulfni nu ecudorp es ,eramru aC .+aN urtnep arotseca aetatilibaemrep
a i[ ieidracidarb ai]irapa uc \zaeziraloped es elelulec ,+aN ed visam
.)41 ,11 ,3( iinuisnetopih
ăcitueparet nî erazilitU .3 .6 .4
ezeulave \s erac iiduts esnirpertn` tsof ua un tnezerp n` \nâP
irdnedodohR nid roletcartxe a erartsinimda al a]narugis i[ aetaticacife
iulusudorp aerazilitu \tadnamocer etse un ,vitom tseca niD .muilof
.eiparetot if n` lategev
n` \rtni muilof irdnedodohR nid tcartxe nu ,aetseca etaot uC
-REPYHITNA visnetrepihitna ereicosa ed iulutaraperp a]nenopmoc
.)21( KCUHCS S MUCINOT
esrevda iițcaeR .4 .6 .4
-i]noc \tirotad ecixot tnus muilof irdnedodohR nid eletcartxE
.enixotonayarg n` iulutun
+
aeret[erc \nimreted aN ed eralulecartni iei]artnecnoc aeret[erC
,)c aidr ac colb ,eidracidar b( lagav iulus unot a ,c aidr a c iulum sitamotua
.etat icixotoruen ed enemon ef i[ mucerp
-ortsag ir\rublut c udorp elen ixotonayarg \ laro erartsinimda aL
,jitrev ,)eeraid ,irut\sr\v ,\]aerg ,\tnednuba ei]avilas( elanitsetni
,i[ ei]aticxe ,rolesaocum i[ iileip lulevin al tirurp i[ \rusra ed ei]aznes
.)41 ,11 ,3( rota r ips e r pots i [ \ralucsum e izilarap , iram ezod n`
121 eralucsavoidrac inuiţcefa ronu lutnematart iş aixaliforp nî elanicidem eletnalP
elairetra iinuisnetrepih aiparetotiF
n
Z
H
O
O
H
n
Z
H
O
H
O
O
O
H
O
H
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H H
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n
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a erabihnI
ei]artnecnoC
ACE \lategev \sruS/vitca uipicnirP
\vitca
*).d.s ± %(
editpeP
05IC lm/gm 2300,0 noitatulG
05IC lm/gm 430,0 \nitalehcotiF
05IC lm/gm 3100,0 tnemgarf - \nienoitolateM
.L munisru muillA
4,1 ± 7,84 lm/gm 30,0 -L-lila-S-)+(-limatulg-L-amag
ludixoflus nietsic
ir\nimreted 2 a aidem ac etamirpxe tnus eletatluzer *
*
-ocalF( .lhaV asoiceps ainayR \nacirema-dus aiceps nid talozi cixot diolacla
iululuciter lulevin al ed eletizoped nid iuluiclac aerarebile \nimreted ;)eaecaitru
.ecinretup eralucsum ii]cartnoc ecudorp ec aeec cimsalpocras
noriM acnA 421
elairetra iinuisnetrepih aiparetotiF
R
2
R
R
3
1
R
4
R
R
4
1
H
C
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H
C
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R O O O
R O O O
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3 C C C
2C C C
1
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3
: EIFARGOILBIB
5 lulotipaC
AIPARETOTIF
ELAIRETRA IINUISNETOPIH
muilof iniramsoR .1 .5
aiceps al ed etatlocer e leznurf \tnizerper
ailimaf nid .L silaniciffo suniramsoR
ed elemun bus \tucsonuc eaecaimaL
.niramzor
tsubrabus nu etse luniramzoR
eleznurF .eneenaretidem elenoz nid ranigiro
a]af ep erbalg ,elises ,ecairoc ,esupo tnus
.\raoirefni aec ep esaotnemot i[ \raoirepus
,roleznurf azab al esupsid ,etaibalib ,elirolF
.eecaloiv – sihcsed urtsabla eraoluc ua
.\lucun o etse lutcurF
,tuc\lp sor im nu era atnalP
.L silaniciffo suniramsoR
.)7 – 4( tarofmac
ăcimihc eițizopmoC .1 .1 .5
: tnus muilof iniramsoR nid evitca e]natsbus ed epurg elelapicnirP
-α ,)%05-02( loenic-8,1 nid tiutitsnoc )%5,2-1( litalov ielu
,)%5-1( linrob ed tateca ,)%52-01( rofmac ,)%62-51( nenip
,)%42-21( loenipret-α ,)%01-5( nefmac ,)%6-1( loenrob
; necrim ,nelifoirac-β ,nenip-β ,nenomil
R
O
O
O
R HC
l
o
e
n
r
o
b
H
C
O
l
i
n
r
o
b
e
d
t
a
t
e
c
a
l
o
e
n
i
c
-
8
,
1
r
o
f
m
a
c
3
H
O
H
O
O
H
H
O
O
H
O
O
C
O
H
c
i
n
i
r
a
m
z
o
r
d
i
c
a
losonrac : \cilcicirt \cinepretid \rutcurts uc erama e]natsbus
i[ eracsu nirp ,losonrac nid ;lonamsor i[ )\ nivlasorcip(
, cilosonrac dica : enepretid etla \za emr of es ,eravresnoc
; lonefidiramsor ,laidamsor
H
O
H
O
O
H
O
HC
O
O
O
H
O
l
o
s
o
n
r
a
c
c
i
l
o
s
o
n
r
a
c
d
i
c
a
cigolocamraf liforP .2 .1 .5
iulumetsis lulevin al cinot tcefe nu era muilof iniramsoR
rorutut lutnematart n` tneicife etse i[ sovren iulumetsis a i[ rotalucric
et s ecA .enuisnetopih n ` visulcni ,ecinorc ii rotalucric ro lii]cnufsid
noriM acnA 031
elairetra iinuisnetopih aiparetotiF
ăcitueparet nî erazilitU .3 .1 .5
:ed \mrof bus artsinimda etaop es lategev lusudorP
\nac o i[ lategev s udorp \]irugnil o-rtnid \raperp es – eizufni
erac \pud tunim 1 ed pmit suaper n` \sal es ;erebreif al \pa uc
etnibreif eizufni ed \nac o etâc \dnamocer eS .\zaertlif es
.znârp ed i[ nu jed lucim ed etnian`
la i[ iuluznârp lupmit n` rahap nu etâc \dnamocer es – niv
; ienic
\pa \ni]up n` \r ut \cip o etâc \dnamoc er es – )5 : 1( \rutcnit
; elapicnirp elesem ed etnian` etunim 51 uc \dlac
etamru C°63-43 al etunim 01 ed etrucs i\b \dnamocer es – i\b
vitom tseca nid i[ cinot tcefe nu era ai aB .suaper ed \ro o ed
. a ] a enimid \tuc\f eiubert
\]nidnet uc evitca rolenaosrep \dnamocer es – elanâm\tp\s i\b
i[ dnekeew ed elel iz n` a]aenimid caf es eli\B .einotopih al
.tap al suaper ed \d aoir ep o ed etamru tnus
i [ e r e b r e i f a l \p a e d u r t i l n u - r t n i d \ r a p e r p e s – e i a b e d \ ] n e s e
\ pud etunim 03 e d pmit suaper n` \sal e s ; lat egev sudorp g 05
.eiab \ru gnis o urtnep \zaezi li tu eS .\ zaertlif es erac
\zaertsinimda es erac tneminil iunu ai]izopmoc n` \rtni – trips
aenuiger n` nretxe \cilpa es( elanoi]cnuf ecaidrac ii]cnufsid n`
.)3 ,2( )iimini
esrevda iițcaeR .4 .1 .5
dnâni]noc nretxe zu ed eletaraperp ,\tagnuledn` erartsinimda aL
etitamred ,emetire animreted top )iniramsoR muelorehteA( litalov ielu
.erazilibisnesotof ed ii]caer uas
ăcimihc eițizopmoC .1 .2 .5
abreh eacaidrac irunoeL
,\nirdihats( izio lacla eni]noc
ediodiri ,)\ ni dirunoel ,\nirunoel .L acaidrac surunoeL
pit ed enepr e tid ,)\dizog uja ,loguja(
edizocilg( edionovalf ,)anispoelagerp-ixoteca-91 ,anidracoel( cinadbal
icinaporplinef i[upmoc ,)iululotecrevc ,iululorefmek ,iululonegipa ela
.)11 ,01 ,6 ( c iloneida fub pit ed ec ino toidrac edizoreteh i[
O
C
H
3
H
N C
+N
H
N
H
N
H
C
H
C
H
C
H
C
O
O
C
O
H
H
O
O
C
2
O
C
H
3
a
n
i
r
u
n
o
e
l
a
n
i
r
d
i
h
a
t
s
cigolocamraf liforP .2 .2 .5
tnus lategev iulusudorp ela evitades i[ evisnetopih eletcefE
. roliziol acla e t a r o t a d
n` etadnamocer tnus abreh eacaidrac irunoeL nid eletcartxE
.evitategev i[ elanoi]cnuf ecaidrac inui]cefa
ăcitueparet nî erazilitU .3 .2 .5
\mrof bus \zaertsinimda es lategev lusudorp tnevcerf iam leC
al \pa uc \nac o al lateg ev sudorp e]irug nil 2 n id \ta raperp eizufni ed
lu tc efE .araes i[ a]aenim id eizufni \nac o etâc \dn a mocer eS .erebreif
.tnematart ed inul avetâc \pud ,\luger ed ,erapa i[ bals etse citueparet
\tlovzed dipar i a m \zaelatsni es erac \sn e tni iam enui]ca O
ni]noc ,abreh eacaidrac irunoeL \gnâl ep ,erac ereicosa ed elelumrof
.muilof eassileM i[ abreh eairallavnoC
.pR
ab reh eacaidr ac irunoeL
abreh eairallavnoC
g 0,001 da ā ā muil of eassileM
s eiceps .f .M
nretni .s .D
esrevda iițcaeR .4 .2 .5
eacaidr ac irunoeL n i d e l e t c a r t x e , i r a m e z o d n ` e r a r t s i n i m d a a L
.)6( iigarortem i[ eeraid ,\cirtsag ei]atiri cudorp abreh
arohpmaC .3 .5
litalov luielu lunetporaets \tnizerper )lurofmac( arohpmaC
iu lerobra r oli]r\p rorutut a \pa ed iropav uc a erane rtna nirp tuni]bo
.eaecaruaL ailimaf nid .beiS arohpmac mumomanniC
- 2 ( r o f m a c - ) R 1 ( - ) + ( % 6 9 n i ]u p l e c e n i ] n o C
O
-β i[ -α ed esuder i]\titnac ed irut\la )\nonanrob
.neno mil ,nenip
: ecituepar et ir\zilitu es ao remun e ra lurofmaC
,citilote rceso hnorb ,rotaripser i[ lartnec citpelana
r
o
f
m
a
c
+
o \tucsonuc ni]up iam ei]acidni O .citamueritna ( )
.a enu isnetop ih \tnizerper
elac ep \zaertsinim da es r ofmac uc eleta r aperp ,enuisne topih n~
\z aevitca ,eramru ac ,i[ rotom osav lurtnec \zae lumits lurofm aC .\laro
,il e ] e ma( esrevda rolii]ca er a etucserc ie]nedic ni \ti rotaD .ai]alucric
es rofm ac u c eletarape r p ,)\moc raihc i[ iisl uvnoc ,riled ,irut\sr\v
. \laro elac ep r a r etraof \z aertsinimda
NIDOROK etse tarelot enib etraof i[ tneicife taraperp nU
,negnilssE ,HbmG neguboR( ®NEFPORT-FUALSIERK-ZREH
nid diulf tcartxe ,larutan rofmac-D \zaicosa lutaraperP .)ainamreG
sud orp tropar ;%69 lon ate :tnevlo s( lecud\p ed eteps aorp etcurf
.tnazitamora ac lotnem i[ )4,1 :1 = tcartxe :lategev
erac lecud\p ed irolf i[ eznurf nid eletcartxe ed eribesoed erpS
iam ,\niugnas aenuiserp cserc etcurf nid eletcartxe ,evisnetopih tnus
.\cinorc erartsinimda al sela
tai]nedive ua )etazimodnar ,etalortnoc-obecalp( ecinilc iidutS
a en uiserp ,eidem \lairet ra aenuiserp et[erc er e icosa \tsaeca \c lutpaf
\niugnas aenuiserp vitacifinmes \zae]neulfni un ,\cilotsaid \niugnas
iin uiserp a \virtopoed ae ret[erC . c aidrac lumtir r o[u et[e r c i[ \cilotsis
ni ugn as luxu lf et[e]\t\n ub m` caid rac iulumti r a i[ iid em elairetra
n` iulutara perp a]neicife \ci f itsuj ec aeec m sitatsot ro n` cirefirep
noriM acnA 431
elairetra iinuisnetopih aiparetotiF
R
1
N
N
N R
O
2
R
R
3
1
H H
C C H
H H H
C C C
H
C H C
a
n
i
e
f
a
c
3 3
a
n
i
m
o
r
b
o
e
t
3 3
a
n
i
l
i
f
o
e
t
3
u a e r a c n emes ealoC n i d e t c a r t x e i [ a n a r a u G n i ] n o c e r a c r o l e t a r a p e r p
.\nief a c n ` tacidir t uni]noc nu
, etatizo vren ,cirts ag trof nocsid cudorp \ niefac ed ir am elezoD
.)3( einmosni
: EIFARGOILBIB
6 lulotipaC
AIPARETOTIF
ECINORC ESAONEV IEȚNEICIFUSNI
nemes inatsacoppiH .1 .6
.A .nis .L munatsacoppih sulucseA ieiceps ele]nimes \tnizerper
arecorp .A .nis .biliG aenatsac
-luv munatsacoppiH .nis .bsilaS
-oppiH ailimaf nid rentreaG erag
ralupop \timuned , eaecanatsac
.csecrop natsac uas citabl\s natsac
nu e tse citabl\s lunatsaC
eznurf uc latneman ro erobra
g n u l , e t a r e s , e s u p mo c – t a m l a p
u c \ b l a e r ao l u c e d i r o l f i [ e t a l o i ] e p
. e l u c i n a p n ` e t ap u r g i i [ o r e t e p
esaonr\c e lus pac tnu s eletcurF
2 – 1 ni]noc e rac ipe] uc etuz\verp
ed ,esaoicul ,erud ,iram e]nimes
\tap o uc et uz\ve rp ,\nu rb eraoluc
eraot\znups eroc \ saoicibla ,eram
.)8 ,7 ,6( iululih .L m unat sacopp ih sulucseA
ăcimihc eițizopmoC .1 .1 .6
,ecinepretirt eninopas %01 – 3 eni]noc nemes inatsacoppiH
,)iululorefmek i[ iululotecrevc ela edizocilgirt i[ -id( edionovalf %3,0
.nodima %06 – 03 i[ litalov ielu ,ilorets
e tse ,\nic se ed elemun bus tucsonuc ,cidi zonopas lulatoT
\v ired erac etalica eci nepr etirt edizocilg 03 ets e p nid tiutitsnoc
: inocilga 2 al ed larutcurts
H HH O H
O
lonegotgnirab i[ lonegicseotorp
1 2
2 2
\tnizerp eledizon opas etaoT .C
H O2
8C H
2
H
) \ d i r a h a z i r t ( \ c id i c u l g \ n e t a c o
H
H
3
.iulunocilga la 3 – C al ed
O
H
H
R
C a l e d H O e l i r \p u r g t n e v c e r F
etacifiretse tnus 22 – C i[ 12 –
,citeca ii zica( icitafila izica uc
HO
==
RR
C
l
o
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g
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t
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n
i
r
a
b
H
l
o
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g
i
c
s
e
o
t
o
r
p
-na ,ciritubozi ,ciritub-litem-α
. )cilgit ,cileg
\nicse-β nid \tutitsnoc etse anicse \c \redisnoc es tnezerp n~
iamun eni]noc( \nicseotpirc ,)edizonopas-liteca-O-22 iamun eni]noc(
i[ \nicse-β ed cetsema nu etse( \nicse-α i[ )edizonopas-liteca-O-82
. )\nicseotpirc
,7( ilodinaicotnaorp i[ edizonopas eni]noc role]nimes lupracireP
.)01 ,9 ,8
cigolocamraf liforP .2 .1 .6
e l a e r a o t c e t o r p o s a v i [ e s ao t a m e d e i t n a , e v i t a d u s x e i t n a e l e t c e f E
.ienicse etarotad tnus nemes inatsacoppiH nid roletcartxe
,\niug nas azats n ` i [ leftla ed ac ,iiro ta malfni elesecorp n~
ae ralirofsof \zaetcefa l a iletodne levin al neg ixo ed suder lutropa
ăcitueparet nî erazilitU .3 .1 .6
etarculerp eiubert e le]nimes ,evitcaoib e tcartxe eni]bo a urtneP
era late nirp etacsu-erp tn u s ele]nim es ,lai]inI .\ l aiceps \c inhet o \pud
es i[ \cipsed es iopA .\t alitnev enib etraof \no z o-rtn` eri]bus tarts n`
3 ed tuni]noc nu uc ,lusudorP .\zaezirevlup es erac \pud C °06 al \cusu
ii ]roporp n` loocla - \pa ed cetsema uc egart xe es ,eninopas %5 –
uc \cetsema es ,ces al erar tnecnoc \pud ,et c artxe et secA .elibairav
edizocilg %02 – 61 ed \lanif ei]artnecnoc o eni]bo a urtnep enirtxed
.)\nicse n` e tamirpx e ( ecinepretirt
etcartxe csesolof es ecinorc esaonev ie]neicifusni lutnematart n~
nretni zu ed etaraperp n` etanoi]idnoc nemes inatsacoppiH nid
,®NINOTOSAV ,ONOM 05 NEVASSE ,02 ®NASUCSEA(
-OCSAP ,N ®NALURTONEV ,S-/N-/DRATER ®NISATSONEV
-IRAV( nretxe i[ )N-/ETROF ®NISRAVIDEM ,OVON ®LONEV
®NASUCSEA ,®NALURTONEV ,LEG NEVUMITS ,PRET
.)71 ,4 ,2( )EBLAS-N ®NISATSONEV ,0,1 EMERC
esrevda iițcaeR .4 .1 .6
ii]cnufsid( esrevda rolii]caer a]nedicni ,\laro erartsinimda aL
uc eletaraperP .\tuz\cs etse )tirurp ,\nergim ,jitrev ,elanitsetniortsag
luzac n~ .\nub iam aec a]narelot \tnizerp \talortnoc erarebile
xetroc inatsacoppiH .2 .6
5 – 3 ed \tsrâv n` elirumar ep ed etatlocer ele]raocs \tnizerper
.nis .biliG aenatsac .A .nis .L munatsacoppih sulucseA ieiceps ela ina
ailimaf nid rentreaG eragluv munatsacoppiH .nis .bsilaS arecorp .A
natsac uas citabl\s natsac ralupop \timuned ,eaecanatsacoppiH
.)91 ,8( c s e c r o p
ăcimihc eițizopmoC .1 .2 .6
,lotexarf ,lotelucse( eniramuc ni]noc citabl\s natsac ed ele]raocS
,\nicse ,ecihetac iruninat ,enovalf ,)arotseca eledizocilg i[ lotelopocs
.) 91 ,01 ,8( \niotnala
O
C
H
3
O
R
O
O
H
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H
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O
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R
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l
g
a
d
i
z
o
x
a
r
f
abreh itolileM .3 .6
ieiceps ela elarolf eli] \timos \tnizerper
ailimaf nid .rseD silaniciffo sutolileM
.\niflus ralupop \timuned ,eaecabaF
uc eecabre \tna lp o et se anifluS
irolf i[ eta]nid nif , e t a ilofirt ,enretla eznurf
esup sid ,uecanoilip ap pit ed ,eneblag ,icim
eiats\p o etse l utcurF .emecar n`
.)9 ,8 ,6( \tnecsihedni
ăcimihc eițizopmoC .1 .3 .6
-udo rp ia i ]neutit snoc iilapicnirP
n~ .iciniramuc ii]avired tnus lategev iulus
vitatitnac \nimoderp \t\psaorp atnalp .rseD silaniciffo sutolileM
-o d ica( citolilem i[ )ciram uc -o-sic d ica( ciniram u c rolizica eledizocilg
\t\psaorp atnalp ,eramru ac ,i[ erodoni tnus aetseca ;)ciramucordihid
iizica al \zaezilordih es eledizocilg eracsu nirP .sorim ed \tispil etse
,u lp mexe ed ; eniramuc a l \zaez inotcal es roir e tlu e rac iro t\znupseroc
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cigolocamraf liforP .2 .3 .6
e m o t p m i s e d e i r e s o \ z a e r o i l e m a abreh itoli leM n i d e l e t c a r t x E
ai]aznes ,aererud tnus muc ecinorc esaonev ie]neicifusni ecitsiretcarac
eS .lumede i[ lutirurp ,enrutcon elepmarc ,”elerg eraoicip“ ed
ac i[ ecinorc esaonev ie]neic ifusni lutnema tart n` \z aertsinimda
.citafmil mede ,citobmort-tsop mordnis ,\tibelfobmort n` tnavujda
ela uc elibarapmoc esaotamedeitna i]\teirporp era aniramuC
cserc abreh itolileM nid eletcartxe i[ aniramuC .cimanefulf iuludica
\saonev aerecraotn` cse]\t\nubm` ,ecitafmil i[ eniugnas rolesav lusunot
.\citafm il acitenic i[
etse \sn` dipar e b r aosba es aniramuc \laro e r artsinimda aL
– 2 iamuN .citapeh jasap lumirp al \tacidir ei]roporp n` \tazilobatem
.\cimetsis ai]alucric n` et[es\ger es \tartsinimda azod nid %6
aniramuc-ixordih-7 tnus ieniramuc ia i]ilobatem iilapicnirP
\tartsinimda azod nid %09 .xorpA .u\s ludinoruculg i[ )anorefilebmu(
.ieniramuc-ixordih-7 la dinoruculg ed \mrof bus \niru nirp \nimile es
,\vitca a]natsbus etse aniramuc-ixordih-7 \c enupuserp es ,leftla eD
.)31 ,4( gurdorp nu raod dniif aniramuc
itolileM nid roletcartxe a]neicife tai]nedive ua ecinilc iidutS
.)31( ) VIXX .bat( cita fmil me de i[ \saon e v \] neicifus ni n` abreh
\zoD
citsongaiD
etcefE \taruD \cinliz tcartxE
i]neicap
)gm(
evitizop etcefe − − \]neicifusni tcartxe : taraperP
\saonev abreh itolileM nid
\tibelf al tazidradnats(
)\niramuc %50,0
\dizotur i[
aered\cs 21 02 mede nid tcartxE
a \vitacifinmes inâm\tp\s citafmil uc abreh itolileM
iulumede \niramuc %02
aered\cs inul 6 etatitnac mede nid tacsu tcartxE
iulumede \tnelavihce citafmil abreh itolileM
gm 8 uc
\niramuc
ăcitueparet nî erazilitU .3 .3 .6
,erata ac lategev lus udorp ,ecitafmil i[ esaon ev elii]cnufsid n~
n` nr etni tâta \zaertsinim da es atsec a nid etuni ]bo etcartxe i[ mucerp
.)31( nr etxe i[ tâc ,i z/\n iramuc g m 03 – 3 a l eraot\znu pseroc \zod
\taraperp eizufni ed \mrof bus azilitu etaop es abreh itolileM
a l \ pa ed \ nac o i[ t a zirev lup lat egev sudo r p e]i rugnil 2 – 1 nid
2 ed eizufni \nac o \dnamocer eS .\zaertlif es etunim 01 \pud ;erebreif
.\saon ev \]neicif usni ed erao [u elemrof n ` iz/iro 3 –
.emsalpatac ed \mrof bus lacol acilpa etaop es lategev lusudorP
ed \lage etatitnac o uc \ zaet c emu es lategev lu sudorp , atsaeca urtneP
.\ tatcefa an oz ep \cilpa e s iopa i[ \csaec\r es \s \sal es , erebreif al \pa
e t a r a p e r p r o n u a ] n e n o p m o c n ` \ r t n i a b r e h itolileM nid etcartxE
®LIZNEMELC :ecinorc esaonev ie]neicifusni lutnematart n` etazilitu
®LONEVOCSAP ,N-/ETROF ®NISRAVIDEM ,®TOLANEV ,TS
. )71 ,31 ,4( OVON
esrevda iițcaeR .4 .3 .6
ăcimihc eițizopmoC .1 .4 .6
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cigolocamraf liforP .2 .4 .6
ed eires o \zaeroilema amozihr itaeluca icsuR nid eletcartxE
ed ei]aznes ,ererud( \cinorc \saonev a]neicifusni nid emotpmis
,tirurp( eladioromeh elinui]cefa i[ )tirurp ,mede ,”elerg eraoicip“
xelpmoc cigolocamraf liforp nu ua ecilorets eleninopaS .)emirutsu
: oviv ni i[ ortiv ni iiduts esaoremun ed tidevod
-α rolirotpecer aeravitca nirp \saonev ei]cirtsnoc cudorp
,icigrenerda
nirp rolemede aeramrof i[ \ralucsav aetatilibaemrep cuder
nid i inacilgoetor p \zaednics erac \miz ne ,iez atsale aerabihni
;ralucsav luiletodne
951 eralucsavoidrac inuiţcefa ronu lutnematart iş aixaliforp nî elanicidem eletnalP
ecinorc esaonev ieţneicifusni aiparetotiF
ăcitueparet nî erazilitU .3 .4 .6
ronu a]nenopmoc n` \rtni amozihr itaeluca icsuR nid etcartxE
,ONOM ®ESAIBONEV ,NEVOCSUR( nretni zu ed etaraperp
,LEG NEVOCSUR( nretxe i[ )®LIRDOBELHP ,ESAIBONEV
lutnematart n` etazilitu )N ®LIRDOBELHP ,®LATCEROCSUR
.ecitafmilonev rolii]cnufsid
icsuR nid roletcartxe a \nretni aerartsinimda \dnamocer eS
iz/ilonegocsur gm 11 – 7 al eraot\znupseroc ezod n` amozihr itaeluca
.)71 ,31(
esrevda iițcaeR .4 .4 .6
.ecitilomeh tnus amozihr itaeluca icsuR nid ecilorets eleninopaS
roledizonopas azilordih nirp eret[an uai erac ,)ilonegocsur( iinocilgA
n~ .ecitilomeh i]\teirporp ua un ,lanitsetniortsag iulutcart lulevin al
etadizocilg rolemrof \raoirepus etalibinopsidoib o ua iilonegocsur ,sulp
e raoirepu s elet nemges n ` b rosba es ,il ibulosopil dniiF .erao t\znupseroc
.lumred i[ lumredipe \]niru[u uc \zaertenep i[ eri]bus iulunitsetni ela
icsuR nid eletcartxe ,\cituecamraf airtsudni n` ,evitom etseca niD
nirp \libalaerp erarculerp o \pud iamun etazilitu tnus amozihr itaeluca
.)8 ,7( ilonegocsur al etatilatot n` etazilordih tsof ua eledizonopas erac
noriM acnA 061
ecinorc esaonev ieţneicifusni aiparetotiF
xetroc sidilemamaH .5 .6
muilof sidilemamaH
elez n urf ,vitcepser i[ ele]r a ocs \tnizerper
-igriv silemamaH aiceps al ed etatlocer
.eaecadilemamaH ailimaf nid .L anain
lutse nid \ranigi r o ,atnalP
uc tsubra nu etse ,droN ed iiciremA
i[ \zab al ecirtemisa ,elavo ,etal eznurf
. )9 ,8( \nebl a g eraoluc ed ,icim irolf
ăcimihc eițizopmoC .1 .5 .6
-raocs la tneu titsnoc lulapicnirP
cetse ma nu ,lunin atilem a mah etse role]
.\zolemamah-liolag-O-id-5,’2-β i[ -α ed .L anainigriv silemamaH
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cigolocamraf liforP .2 .5 .6
ăcitueparet nî erazilitU .3 .5 .6
esrevda iițcaeR .4 .5 .6
a \nretxe aerartsinimda al esrevda ii]caer etalanmes tsof ua uN
.xetroc sidilemamaH nid roletaraperp
-emamaH nid role ta raperp a \tagnuledn` \nretni ae r artsinimdA
eratcefa i[ \cirtsag eratiri ed enemonef animreted etaop muilof sidil
. )91 ,31 ,01 ,8( \citapeh
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]anihetacipe-)-(-)8→β4(-nihetacipe-)-([
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citsongaiD iremogilo
etcefE \taruD \cinliz uidutS
i]neicap -otnaorp
)gm(
icilodinaic
\lai]rap aiserger inul 2 x3 \]neicifusni obecalp ®LONEGONCYP
: a \lat ot uas 001 \cinorc \saonev -ulbud
iirerud - ecirav bro
iulumede - lelar a p
e d iei]az nes -
”elerg eraoicip“
iam \]neicife -\tp\s 4 x3 \]neicifusni -apmoc ®LONEGONCYP
urtnep \tucserc inâm 021 \cinorc \saonev vitar
®LONE G ONCYP x2 ® NISATSONEV
: ni r p \t a ula ve 003
aemir\m -
rolemede
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emotpmis
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ed ecires irolav -
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LDH
uas gm 05 uc etnetsizerortsag etamlif etamirpmoc - )porhtniW ifonaS( ®NOLETODNE *
iremogilo n` tazidradnats irugurts ed e]nimes nid tacifirup tcartxe gm 051
icilodinaicotnaorp
etse i[ \zetnisimes nirp eni]bo es iz\tsa erac rolecirtic lupracirep nid \dizonovalf **
\nimreted ; gm 005 ®NOLFAD ,®XELARTED ,NIMSOID eletaraperp n` \tanoi]idnoc
,mede( \cinorc \saonev a]neicifusni nid emotpmis ronu a \latot uas \lai]rap eiserger o
.)”elerg eraoicip“ ed ai]aznes ,enrutcon epmarc ,ererud
: EIFARGOILBIB
nosirraH :nI .roli]\timertxe ela eralucsav iloB .JV uazD ,AM regaerC .1
.2551-2451 ,aroeT 1002 © thgirypoC .enretni ienicidem eliipicnirP
lanoitaR :nI .metsys ralucsavoidraC .EV relyT ,R lesnäH ,V zluhcS .2
.861-701 ,1002 ,galreV-regnirpS :grebledieH ,nilreB .yparehtotyhP
bus( \nretni \nicideM :nI .rolenev eliloB .A ui[eilI ,V uvrâP ,L misarehG .3
.2231-1721 ,4002 ,\lacideM .dE :it[erucuB .)II .lov ;.L misarehG ai]cader
.enicideM labreH :nI .esaesid ralucsavoidraC .V nnamletniF ,FR ssieW .4
.281-731 ,0002 ,galreV emeihT groeG :kroY weN ,tragttutS
.1002 ,\lacideM .dE :it[erucuB .lacidem ranoi]ciD .V usuR .5
\lacideM .dE :acopaN-julC .)III .lov( \cituecamraf \cinatoB .M [am\T .6
.9991 ,”unagei]aH uiluI“ \ratisrevinU
.ilarutan icinepret i[upmoc - eizongocamraF :nI .ediorets ,edionepretirT .I aginO .7
.101-54 ,7002 ,”unagei]aH uiluI“ \ratisrevinU \lacideM .dE :acopaN-julC
al A al ed elanicidem etnalP .C eiaosotorpA ,M unaicn\H ,A noriM ,U ucsen\tS .8
.4002 ,”apoP .T .rG“ .dE : i[aI .citueparet seretni ed rolesudorp ela iifargonom ;Z
,elanicidem etnalP :nI .edizonopaS .U ucsen\tS ,E ucserogirG ,I ieluiC .9
.586-036 ,I .lov ,3991 ,\lacideM .dE :it[erucuB .eiparetotif i[ eimihcotif
:revodnA .stnalp lanicideM ,yrtsimehcotyhP ,ysongocamrahP .J notenurB .01
.5991 ,dtL tpecretnI
.eliforp cituepareht dna scitenikocamrahp ,ygolocamrahp :nicseA .RC irotriS .11
.391-381 :)3( 44 ;1002 hcraeseR lacigolocamrahP
noriM acnA 071
ecinorc esaonev ieţneicifusni aiparetotiF
-itna dna esatsale-itnA .L enebiaS ,G inidlA ,R inafetS ,M iniraC ,MR onicaF .21
,xileh aredeH morf sninegopas dna sninopas fo seitivitca esadinorulayh
rieht ot gnitubirtnoc srotcaf :sutaeluca sucsuR dna munatsacoppih sulucseA
)miehnieW( .mrahP .hcrA .ycneiciffusni suonev fo tnemtaert eht ni ycaciffe
.427-127 :823 ;5991
.3002 ,POCSE .shpargonoM POCSE *** .31
ycaciffe lacinilc evitarapmoC .WP rekcüL ,V tsoJ ,P nielK ,M fuaknU ,D nheR .41
cinorhc htiw stneitap ni tcartxe tuntsehc-esroh dna sniturexo fo ytilibarelot dna
.784-384 :)I( 64 ;6991 .seR gurD/.hcsroF-.mienzrA .ycneiciffusni suonev
suonev cinorhc rof tcartxe dees tuntsehc-esroH .E tsnrE ,HM relttiP .51
:431 ;8991 lotamreD hcrA .weiver citametsys desab-airetirc a :ycneiciffusni
.0631-6531
– ycneiciffusni suonev cinorhc fo ypareht lanoitaR .K ekseerG ,B regnillittO .61
CMB .tcartxe sdees tuntsehc-esroh fo esu cituepareht eht fo stimil dna secnahc
.5-1 :1 ;1002 sredrosiD ralucsavoidraC
.5991 ,nizideM rüf galreV rotnaC oitidE : .ttrüW/frodneluA .etsiL etoR *** .71
aidrauG ,P onarreS ,J odagleD ,E zeuqzáleV ,JF odilleB-zoñuM ,MM onabircsE .81
.332 :73 ;7991 sititamreD tcatnoC .nicsea ot eud airacitru tcatnoC .J édnoC ,J
mrahpdeM :tragttutS .slacituecamrahpotyhP dna sgurD labreH .M lthciW .91
.4991 ,srehsilbuP cifitneicS
; 3002 weiveR enicideM evitanretlA .)sCPO( snidinaycohtnaorp ciremogilO *** .02
.054-244 : )4( 8
fo seitreporp cigoloib dna ytivitca tnadixoitnA .F iligriV ,G hcabmiR ,L rekcaP .12
eerF .lonegoncyP ,krab )amitiram suniP( enip morf tcartxe hcir – nidinaycorp a
.427-407 :)6/5( 72 ;9991 enicideM & ygoloiB lacidaR
;0002 aiparetotiF .ycneiciffusni suonev cinorhc ni ®lonegoncyP .P ilegnacrA .22
.442-632 :17
cinorhc ni ®lonegoncyP dna ®nisatsoneV fo yduts evitarapmoC .R hcoK .32
.5-1 :61 ;2002 .seR .rehtotyhP .ycneiciffusni suonev
7 lulotipaC
IȘ IEZORELCSORETA AIPARETOTIF
EVIZULCO ELAIRETRA IILOB
cigolocamraf liforP .1 .1 .7
a ] n e i c i f e t a i ] n e d i v e u a e c in i l c i [ r o t a r o b a l e d i i d u t s e s a o r e m u N
.iezorelcsoreta lutnematart i[ aerineverp n` iuluiorutsu
ed irotcaf iinu \zae]neulfni iorutsu nid eletaraperp i[ luiorutsU
-omeh ,tebaid ,enuisnetrepih ,eimedipilrepih( \zorelcsoreta n` csir
ecitorelcsoreta rolinuizel ai]irapa niverp ,pmit i[aleca n` ,i[ )\zats
tcefe( etnetsixe rolinuizel aiserger \nimreted i[ )negoretaitna tcefe(
.)8( )citorelcsoretaitna
n` csir ed irotcaf ronu arpusa iuluiorutsu a]neulfnI
\zorelcsoreta
.\zorelcsoreta n` rojam csir ed rotcaf nu etse aimedipilrepiH
, n e o j a ( a r o t s e c a i a i ] a r u f lu s i ] n e u t i t s n o c i i n u i [ i o r u t s u e d e l e t c a r t x E
cuder )aniitid-3,1-H4-liniv-2 ,lilaid ed aruflusid ,\nicila ,neojalitem
t a rotad etse l utcefE .% 07 -02 e d ei]r oporp n` lorets eloc ed azetnis
-A oC-GM H( iezatcuder- AoC -liratulg litemixord ih ii]\ti vitca iir\bihni
levin al iululoretseloc azetnisoib n` \tacilpmi \mizne ,)azatcuder
.\vitca iam aec etse anicila ,i]aruflus ii]avired ertniD .citapeh
aenuisnetrepih etse \zorelcsoreta n` rojam csir ed rotcaf tla nU
cudorp luneoja i[ anicila ,iorutsu ed sopa lutcartxE .\lairetra
ae n ui]ca bu S .\lairetra aenuisn e t dacs ,eram ru ac ,i[ e i]atalidosav
es ,ralucsav eleterep nid e deten e r alucsum rolelu lec lulevin al ,arotseca
ec aeec \zaeziraloprepih es \ralulec anarbmem ,+K ed elelanac dihcsed
,ralulecartni +2aC aerecudeR .+2aC ed iuluxulfni a ered\cs o \nimreted
a eraxaler o al ecudnoc ,litcartnoc iulusecorp libasnepsidni
.eralu c sav edeten ii rutalucsum
noriM acnA 671
evizulco elairetra iilob iş iezorelcsoreta aiparetotiF
IC
05
enui]carF / tcartxE
tcefE \zod/ cigoloib tropuS
i]neutitsnoC/\vitcartxe
\tazilitu
eratehcalp iir\gerga i[ iezilonirbif arpusa etcefE
aerabihni 002 - 04 − diflusidlilaiD
iir\gerga lm/gμ
a i[ eratehcalp
001 - 5 diflusirtlilaiD
ed iei]erces
lm/gμ
2AXT
aerabihni = 05IC n` \tagob \msalp sopa tcartxE
iir\gerga 064 eniugnas etehcalp
esudni eratehcalp lm/gμ
negaloc ed = 05IC \vitcartxe enui]carF
091 lulatot dnâni]noc
lm/gμ iralop roli]nenopmoc
= 05IC \niilA
502
lm/gμ
41 = 05IC \nicilA
lm/gμ
= 05IC \vitcartxe enui]carF
2,31 lulatot dnâni]noc
lm/gμ roli]aniflusoit
= 05IC \nizonedA
11,0
lm/gμ
02 > 05IC \nizonauG
lm/gμ
41 = 05IC latot egnâs \nicilA
lm/gμ
= 05IC \nizonedA
11,0
lm/gμ
IC
05
enui]carF / tcartxE
tcefE \zod/ cigoloib tropuS
i]neutitsnoC/\vitcartxe
\tazilitu
iulunegixo ela evitcaer iiceps ed iei]cudorp arpusa etcefE
aerabihni Mm 81,0 − \nicilA
iir\dixorep
ed esudni ecidipil
dica
+2
eF/cibrocsa
aerabihni = 05IC eticolunarg iorutsu ed erebluP
ed iei]cudorp 093 retse uc etavitca
noina lacidar lm/gμ lobrof ed
dixorepus
ei]cudorp 1 al \nâp \niila n` ti]\gobm` tcartxE
ed \tucserc lm/gm etativitca ed tispil
noina lacidar \cizaniila
dixorepus
aerecuder − − )\niila %3,1( sopa tcartxE
rolilacidar
i]arebile lixordih
ai]caer nirp
notneF
ăcitueparet nî erazilitU .2 .1 .7
\mrof bus \zaertsinimda es sublub ivitas iillA tnevcerf iam leC
: )5 ,4( ed
aetatidimu ,iir\vresnoc la i[ iir\csu lupmit n~ .ereblup
etrap o ,eramru ac ,i[ iezaniila aetativitca \zaetilicaf \laudizer
.pR
0,061/0,2 pelaS murebuT sinigalicuM
0,02 ivitas iillA arutcniT
0,002 da eatirepip eahtneM sutiripS
oitulos .f .M
\ ru g n i l 1 , n r e t n i . s . D
.pR
0,08 ivitas iillA supuriS
0,001 da sutisopmoc eassileM sutiripS
oitulos .f .M
iz / ]gl 1 x 3-2 ,nretni .s .D
esrevda iițcaeR .3 .1 .7
etalanmes tsof ua iorutsu ed roletaraperp aerartsinimda aL
ed ir\ts ,ecimred ecigre la ii]caer ,\]aerg ,lani tsetnior tsag trofnocsid
,\tinir ,\cigrela \tivitcnujnoc ,rar iam tlum ,i[ enuisnetopih
al e r apa erac jatnavazed lul apicnirp \sn` etse a nelaH .ems apsohnorb
i]neicap i]lum \nimreted erac i[ iorutsu ed roletaraperp aerartsinimda
iam pmit ed \daoirep o ep erasecen elezod ezert sinimda i[` un \s
. \tagnuledn`
uc tnetimocnoc \ zaertsinimda es un i o rutsu ed eletaraperP
aeragerga \bihni i[ azilonirbif et[erc luiorutsU .etnalugaocitna
.roletnalugaocitna aenui]ca \zae]netop ,eramru ac ; \ratehcalp
ed leftsa ed iruzac esaor em un \zaenoi]nem eta til aiceps ed arutaretiL
ed zac nu i[ raihc ,enr e tni iigaromeh al sudn oc ua erac inui]caretni
\tacidniartnoc etse ,aenemesa eD .\latel \nretni eigaromeh
.)5 ,4( ivisnetrepihitna i]nega uc \tnetimocnoc aerartsinimda
muilof earanyC .2 .7
ailimaf nid .L sumylocs aranyC ieiceps eleznurf \tnizerper
.eranihgna \timuned ,eaecaretsA
noriM acnA 491
evizulco elairetra iilob iş iezorelcsoreta aiparetotiF
, e t a t c e s - t a n e p e zn u r f \ t n i z e r p , \ n a e e n a r e t i d e m e n i g i r o e d , a t n a l P
;\raoirefni a]af ep esaotnemot – solsâp i[ \raoirepus a]af ep erbalg
ed ,esaolubut ,elirolF .nips nu etâc n` \nimret es roleznurf eletnemges
uc esaolu bolg iidotna n` eta purg tnus ,eec a loiv – ei[ or eraoluc
tn us el e tcurF .eloilof e d irudn â r etlum iam nid t amrof lurculovni
.)51 ,41 ,31( eiubl\g eraoluc ed supap uc enehca
.L sumylocs aranyC
ăcimihc eițizopmoC .1 .2 .7
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-eloretselocopih i]\teirporp ua muilof earanyC nid eletcartxE
.enegoretaitna i[ etnaimepilopih ,etnaim
,lapicnirp n` ,\tarotad etse \tnaimeloretselocopih aenui]cA
.i e niranic i [ ieniloetul
,muilof earanyC ed roletcartxe a \laro aerartsinimda aL
,iulunocilga aerarebile uc \citamizne \zilordih o \refus adizoranic
-β aenui]ca bus citapeh i[ lanitsetni levin al col era azilordiH .aniloetul
-litemixordih aetativitca \bihni \tarebile aniloetuL .iezadizoculg
eiehc lor uc \mizne ,)iezatcuder AoC-GMH( iezatcuder AoC-liratulg
.)41( )12 .gif( citapeh lutuse] n` iululoretseloc a ovon ed azetnis n`
ăcitueparet nÎ erazilitU .3 .2 .7
n ` e c a r \ s e t e i d i en u l a t n a v u j d a a c \ z a e z i l i t u e s l a t e g e v l u s u d o r P
eS .eimedipilrepih ed etaredom i[ erao[u rolemrof lutnematart n` edipil
n` tacsu sopa tcartxe uas eizufni ed \mrof bus a rtsinimda etaop
.)11( i z/tacsu lateg ev s udorp g 01 – 5 al er ao t\znups eroc etatitnac
a]nenopmoc n` \rtni abreh earanyC nid tacsu sopa tcartxe nU
etcefe uc )\luspac/tcartxe gm 023( ETROF ®LS RAPEH iulutaraperp
.)21( etnaimepilopih i[ etnaimeloretselocopih
esrevda iițcaeR .4 .2 .7
ii]cnufsid animreted top eranihgna ed eznurf nid eletcartxE
a l etati libisnes uc ii]neic ap al ecigrela ii]caer i[ erao[u elani tsetniortsag
,le]e[um( eaecaretsA ailimaf nid iiceps al etnezerp elenepretivcses
.)elenebl\g ,eid\p\p ,iululeciro[ – adaoc
n` eranihgna nid r oletara perp aerartsinim da \tac idniartnoc etsE
.)11( \tirtsag i[ erailib roli\c a ei]curtsbo ed zac
noriM acnA 891
evizulco elairetra iilob iş iezorelcsoreta aiparetotiF
.L abolib ogkniG
ăcimihc eițizopmoC .1 .3 .7
ela ecitueparet ir\ zilitu i[ e cigolocamr a f inui]ca e lesaoremuN
etr ap caf er a c nid xelpm ocotif iu nu etarotad t nus lategev iulusudorp
:ed etatnezerper tnus eledionovalF .elenepret i[ eledionovalf
i[ iululotecrevc ,iululorefmek ela edizocilgirt i[ -id ,-onom
-p ludica uc etacifiretse edizocilgid sela iam( iululotenmarozi
;)ciramuc
;)eralit e m ed i\s ii ]avired i[ \n ov alfotnem a( enovalfib
;)\nihetacolag ,\nihetacolagipe ,\nihetacipe ,\nihetac( ilo-3-navalf
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dilabolib A adilogknig
cigolocamraf liforP .2 .3 .7
ogkniG nid roletcartxe ela ecitueparet elii]acidni nid anU
\cirefirep \vizulco \lairetra alaob \tnizerper o muilof eabolib
.)\tnetimretni ai]acidualc(
e r a c e p a ] n a t s i d c s e r c muilof eabolib ogkn iG n i d e l e t c a r t x E
\grucrap o \s top )eniatnoF II luidats( enui]cefa \tsaeca uc ii]neicap
nu ed \tanimreted etse aereruD .rolebmag lulevin al ererud i]mis a \r\f
es i[ eraoir efni rolerbm e m la ralu c sum lutuse] nid n e gixo ed ticifed
ed ,\zairav erac \]natsid o srucrap ua ii]neicap ec \pud \zaelatsni
.m 003 i[ 03 ertn` ,iecibo
nid tiutitsnoc ,muilof eabolib ogkniG nid vitca luxelpmocotiF
iulegnâs ela ecigoloer eli]\teirporp et[e]\t\nubm` ,enepret i[ edionovalf
. \niugnas ai] alu cric leftsa dnâlumits
a]nalab ed \ta]neulfni cinretup etse iulegnâs aigoloeR
aeragerga \bihni 2IGP .)2AXT/2IGP( 2A naxobmort/2I \nidnalgatsorp
eragerga ecudni 2AXT ec pmit n` ei]atalidosav ecudorp i[ \ratehcalp
sela iam ,iulunegixo ela evitcaer eliicepS .ei]cirtsnocosav i[ \ratehcalp
ed rolelevin iiret[erc lusnes n` urbilihce tseca \zaetcefa ,icidipil iizixorep
n` lutuni]noc nirp ,muilof eabolib ogkniG nid eletcartxE .2AXT
rotatpac nu ac \zaenoi]ca )ilo – 3 – navalf ,edizonovalf( ilonefilop
noina lulacidar( iulunegixo ela evitcaer iiceps elenu ed \]af )regnevacs(
,i[ \cidipil eradixorep ed elesecorp \bihni ,)lixordih lulacidar ,dixorepus
\s elibapac iulunegixo ela evitcaer iiceps ed elelevin cuder ,eramru ac
.)ratehcalp tnagerga i[ rotcirtsnocosav( 2AXT ela iret[erc enimreted
,B adilogknig laiceps n` ,eledilogknig ,etrap \tla ed eP
era vitca ed lurotcaf ed \sudn i \ratehcalp ae ragerga \zaezinogatna
.)FA P( \ratehcalp
roletcartxe a]neicife taulave ua ecinilc iiduts esaoremuN
\lairetra alaob uc ii]neicap al muilof eabolib ogkniG nid etazidradnats
u a etaiduts eletcartxe eli r uzac etaot n~ .)XXX . b at( \ciref irep \vizulco
.g if( i irerud aeralatsni a l \n â p \sru crap a]nats id v itacifinm es tucserc
.)61 ,11 ,5( )22
102 eralucsavoidrac inuiţcefa ronu lutnematart iş aixaliforp nî elanicidem eletnalP
evizulco elairetra iilob iş iezorelcsoreta aiparetotiF
ăcitueparet nî erazilitU .3 .3 .7
n u uc etazidradna ts etacsu roletcartxe a erazil itu \dnamocer eS
-5 i[ )ecinovalf edizocilg n` etamirpxe( edionovalf %72-22 ed tuni]noc
%2,3-6,2 i[ C ,B ,A edilogknig %4,3-8,2( ecinepret enotcal %7
i[ inegrela ,*icilogknig iizica tâta i]atr\pedn` tsof ua erac nid )dilabolib
ai]brosba vitacifinmes \zaetimil erac eledionovalfib i[ tâc ,icixotoruen
.evitca roliipicnirp
nid etu ni]bo elaice ps et cartxe \u od iamun \dn a mocer E aisimoC
:lategev sudorp tropar ;\pa-\noteca : tnevlos( muilof eabolib ogkniG
:\citueparet n` erazilitu urtnep )1 :05 ed tcartxe
amrof bus )HbmG ebawhcS ramlliW .rD( 167 bGE
;®NAKÖR ,®NINOBET roletaraperp
bus( mpp 5 \csae[\ped \s eiubert un icilogknig izica n` lutuni]noc 167 bGE urtnep *
)167 bGE g 001/icilogknig izica gm 5,0
302 eralucsavoidrac inuiţcefa ronu lutnematart iş aixaliforp nî elanicidem eletnalP
evizulco elairetra iilob iş iezorelcsoreta aiparetotiF
esrevda iițcaeR .4 .3 .7
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,31( enidnalgatsorp i[ \nizoneda ,emizne ,enietorp ,i[arg izica ronu ela
.)51 ,41
etse \paec nid ro letaraperp a \citor elcsoret aitna aenui]cA
.ien iil a olcic lai c eps n` ,flus uc roli[up moc \tarotad
eraot\znupseroc \zod n` tartsinimda ,eraserp ed t\psaorp lucuS
.tnaimepilopih ro[u nu etse ,iz/i]epsaorp iblub g 05 al
urtnep \paec nid r oletaraperp aerazili tu \cidni E aisimoC
n` aeratnian` uc \tado rapa erac eralucsav rolir\cifidom aerineverp
.azorelcsoreta i[ \r\mun es erac ertnirp ,\tsrâv
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