1 MINISTERUL OCROTIRII S+N+T+|II AL REPUBLICII MOLDOVA
UNIVERSITATEA DE STAT DE MEDICIN+ {I FARMACIE NICOLAE TESTEMI|ANU Gheorghe PALADI Olga CERNECHI Obstetric= patologic= Manual Vol. II Chi[in=u Centrul Editorial-Poligrafic Medicina 2008 2 GH. PALADI, OLGA CERNECHI CZU 618.1(075.8) P14 Aprobat de Consiliul Metodic Central al USMF Nicolae Testemianu proces-verbal nr. 7 din 2 februarie 2006 Autori: Gheorghe PALADI academician ARM, d.h..m., profesor universitar Olga CerneChi d.h..m., profesor universitar, ef catedr Obstetric i Ginecologie (Rezideniat)
Colectivul de autori: Taisia Eanu d..m., confereniar universitar Zinaida Srbu d..m., confereniar universitar Ia. Metaxa d..m., confereniar universitar Uliana Tabuic d..m., asistent universitar S. Hodorogea d..m., asistent universitar Larisa Catrinici asistent universitar Ludmila Stavinskaia asistent universitar Corina Iliadi-Tulbure medic doctorand V. Moin d.h..m., profesor universitar E. Guu d.h..m., confereniar universitar D. Casian d..m., confereniar universitar N. Cuco d..m., confereniar universitar
Asisten computerizat: Diana Savva Redactor: Valentina Batr Coperta: Veaceslav Popovschi Machetare computerizat: Elena Curmei Corectori: Nadejda Koporskaia, Tatiana Colin CEP Medicina, 2008 ISBN 978-9975-915-32-8 Gh. Paladi, O. Cernechi, 2008 MINISTRY OF HEALTH AND SOCIAL PROTECTION OF REPUBLIC OF MOLDOVA STATE UNIVERSITY OF MEDICINE AND PHARMACY NICOLAE TESTEMI|ANU Gheorghe PALADI Olga CERNECHI Pathological obstetrics Manual Vol. II Chi[in=u Editorial Centre-Poligrafic Medicine 2008 Descrierea CIP a Camerei Naionale a Crii Paladi, Gheorghe Obstetric patologic : Man. / Gheorghe Paladi, Olga Cernechi; Univ. de Stat de Medicin i Farmacie Nicolae Testemianu. Ch.: CEP Medicina, 2008. ISBN 9789975915311 Vol. 2. 2007. 744 p. ISBN 9789975915328 : 100 ex. CZU 618.1(075.8) ntreprinderea de Stat, Firma Editorial-Poligrafic Tipografia Central, MD-2068, Chiinu, str. Florilor, 1. Tel.: 43-03-60, 49-31-46 OBSTETRIC PATOLOGIC 3 MINISTRY OF HEALTH AND SOCIAL PROTECTION OF REPUBLIC OF MOLDOVA STATE UNIVERSITY OF MEDICINE AND PHARMACY NICOLAE TESTEMI|ANU Gheorghe PALADI Olga CERNECHI Pathological obstetrics Manual Vol. II Chi[in=u Editorial Centre-Poligrafic Medicine 2008 4 GH. PALADI, OLGA CERNECHI It was approved by Methodic Central Council of USMF Nicolae Testemianu, verbal-report nr. 7 from 2 february 2006 Editors: Gheorghe PALADI academician of SA RM, universitary professor Olga CerneChi universitary professor, chairman department of Obstetrics and Gynecology (for rezidents)
Part editors: Taisia Eanu universitary lecturer Zinaida Srbu universitary lecturer Ia. Metaxa universitary lecturer Uliana Tabuica universitary assistant S. Hodorogea universitary assistant Larisa Catrinici universitary assistant Ludmila Stavinskaia universitary assistant Corina Iliadi-Tulbure candidate for doctors degree V. Moin universitary professor E. Guu universitary lecturer D. Casian universitary lecturer N. Cuco universitary lecturer Computer assistance: Diana Savva Editor: Valentina Batr Cover: Veaceslav Popovschi Computer upmaking: Elena Curmei Corectors: Nadejda Koporskaia, Tatiana Colin CEP Medicina, 2008 ISBN 978-9975-915-32-8 Gh. Paladi, O. Cernechi, 2008 OBSTETRIC PATOLOGIC 5 Aprobat de Consiliul Metodic Central al USMF Nicolae Testemianu proces-verbal nr. 7 din 2 februarie 2006 LISTA AUTORILOR Gheorghe Paladi Academician al A a Republicii Moldova Doctor habilitat n tiine medicale Profesor universitar Catedra Obstetric i Ginecologie (Rezideniat) Universitatea de Stat de Medicin i Farmacie Nicolae Testemianu, Chiinu Olga Cernechi Doctor habilitat n tiine medicale Profesor universitar Prorector pentru asigurarea calitii i integrrii n nvmnt ef catedr Obstetric i Ginecologie (Rezideniat) Universitatea de Stat de Medicin i Farmacie Nicolae Testemianu, Chiinu recenzeni: Marin Rotaru Doctor habilitat n tiine medicale Profesor universitar Universitatea de Stat de Medicin i Farmacie Nicolae Testemianu, Chiinu Catedra Obstetric i Ginecologie a Facultii de Medicin General Traian Rebedea Profesor universitar Catedra Obstetric i Ginecologie (Romnia)
6 GH. PALADI, OLGA CERNECHI It was approved by Methodic Central Council of USMF Nicolae Testemianu, verbal-report nr. 7 from 2 february 2006 EDITORS Gheorghe Paladi Academician of SA Republic of Moldova Universitary professor Department of Obstetrics and Gynecology (for rezidents) State University of Medicine and Pharmacy Nicolae Testemianu, Chiinu Olga Cernechi Universitary professor Chairman department of Obstetrics and Gynecology (for rezidents) State University of Medicine and Pharmacy Nicolae Testemianu, Chiinu Reviewers: Marin Rotaru Universitary professor Department of Obstetrics and Gynecology State University of Medicine and Pharmacy Nicolae Testemianu, Chiinu Traian Rebedea Universitary professor Department of Obstetrics and Gynecology (Romnia)
OBSTETRIC PATOLOGIC 7 AU COLABORAT Taisia eanu Doctor n tiine medicale Confereniar universitar Catedra Obstetric i Ginecologie (Rezideniat) Universitatea de Stat de Medicin i Farmacie Nicolae Testemianu, Chiinu Consultant SCM nr.1 Zinaida Srbu Doctor n tiine medicale Confereniar universitar Catedra Obstetric i Ginecologie (Rezideniat) Universitatea de Stat de Medicin i Farmacie Nicolae Testemianu, Chiinu Consultant SCM nr.1 Ia. Metaxa Doctor n tiine medicale Confereniar universitar Catedra Obstetric i Ginecologie (Rezideniat) Universitatea de Stat de Medicin i Farmacie Nicolae Testemianu, Chiinu Uliana Tabuic Doctor n tiine medicale Asistent universitar Catedra Obstetric i Ginecologie (Rezideniat) Universitatea de Stat de Medicin i Farmacie Nicolae Testemianu, Chiinu S. hodorogea Doctor n tiine medicale Asistent universitar Catedra Obstetric i Ginecologie Universitatea de Stat de Medicin i Farmacie Nicolae Testemianu, Chiinu 8 GH. PALADI, OLGA CERNECHI Larisa Catrinici Asistent universitar Catedra Obstetric i Ginecologie Universitatea de Stat de Medicin i Farmacie Nicolae Testemianu, Chiinu Ludmila Stavinskaia Asistent universitar Catedra Obstetric i Ginecologie (Rezideniat) Universitatea de Stat de Medicin i Farmacie Nicolae Testemianu, Chiinu Corina Iliadi-Tulbure Medic doctorand Catedra Obstetric i Ginecologie (Rezideniat) Universitatea de Stat de Medicin i Farmacie Nicolae Testemianu, Chiinu V. Moin Doctor habilitat n tiine medicale Profesor universitar Directorul Centrului Naional de Sntate Reproductiv i Genetic Medical e. Guu Doctor habilitat n tiine medicale Confereniar universitar Catedra Chirurgie General i Semiologie Universitatea de Stat de Medicin i Farmacie Nicolae Testemianu, Chiinu D. Casian Doctor n tiine medicale Confereniar universitar Catedra Chirurgie General i Semiologie Universitatea de Stat de Medicin i Farmacie Nicolae Testemianu, Chiinu n. Cuco Doctor n tiine medicale Confereniar universitar Catedra Medicin de Familie Universitatea de Stat de Medicin i Farmacie Nicolae Testemianu, Chiinu OBSTETRIC PATOLOGIC 9 CONTRIBUTORS Taisia eanu Universitary lecturer Department of Obstetrics and Gynecology (for rezidents) State University of Medicine and Pharmacy Nicolae Testemianu, Chiinu Zinaida Srbu Universitary lecturer Department of Obstetrics and Gynecology (for rezidents) State University of Medicine and Pharmacy Nicolae Testemianu, Chiinu Ia. Metaxa Universitary lecturer Department of Obstetrics and Gynecology (for rezidents) State University of Medicine and Pharmacy Nicolae Testemianu, Chiinu Uliana Tabuica Universitary assistant Department of Obstetrics and Gynecology (for rezidents) State University of Medicine and Pharmacy Nicolae Testemianu, Chiinu S. hodorogea Universitary assistant Department of Obstetrics and Gynecology State University of Medicine and Pharmacy Nicolae Testemianu, Chiinu Larisa Catrinici Universitary assistant Department of Obstetrics and Gynecology State University of Medicine and Pharmacy Nicolae Testemianu, Chiinu 10 GH. PALADI, OLGA CERNECHI Ludmila Stavinskaia Universitary assistant Department of Obstetrics and Gynecology (for rezidents) State University of Medicine and Pharmacy Nicolae Testemianu, Chiinu Corina Iliadi-Tulbure Candidate for doctors degree Department of Obstetrics and Gynecology State University of Medicine and Pharmacy Nicolae Testemianu, Chiinu V. Moin Universitary professor Director of National Health Reproductive and Medical Genetics Center e. Guu Universitary lecturer Department of Surgery State University of Medicine and Pharmacy Nicolae Testemianu, Chiinu D. Casian Universitary lecturer Department of Surgery State University of Medicine and Pharmacy Nicolae Testemianu, Chiinu n. Cuco Universitary lecturer Department of Family Medicine State University of Medicine and Pharmacy Nicolae Testemianu, Chiinu OBSTETRIC PATOLOGIC 11 CUPRINS Prefa\= ........................................................................................................................ 19 CAPITOLUL I Patologia extragenital= asociat= sarcinii .................................................................. 23 Generalit=\i .............................................................................................................. 23 Bolile aparatului cardiovascular. Gh. Paladi, N. Cuco[ .......................... 24 Patologia sistemului respirator. U.Tabuica .................................................. 39 Patologia hepatic=. O. Cerne\chi .................................................................... 49 Bolile tractului urinar. O. Cerne\chi .............................................................. 54 Endocrinopatiile. Gh. Paladi ............................................................................ 62 Obezitatea. Gh. Paladi ...................................................................................... 76 Sindromul antifosfolipidic. Gh. Paladi .......................................................... 78 Patologia ocular=. O. Cerne\chi, U. Tabuica ............................................... 87 Tulbur=rile hematologice ]n sarcin=. Gh. Paladi ........................................ 91 CAPITOLUL II Gestoza precoce. Nauseea [i voma gravidelor. Gh. Paladi, U. Tabuica ........................................................................................ 116 CAPITOLUL III St=rile hipertensive ]n sarcin=. Gh. Paladi, S. Hodorogea ..................... 121 CAPITOLUL IV Izoimunizarea dup= Rh-factor. O. Cerne\chi ............................................. 155 CAPITOLUL V Prematuritatea. O. Cerne\chi ......................................................................... 177 CAPITOLUL VI Patologia anexelor fetale. Gh. Paladi, U. Tabuica .................................... 190 CAPITOLUL VII Boala trofoblastic= gesta\ional= (BTG). U. Tabuica, C. Iliadi - Tulbure .. 223 CAPITOLUL VIII Sarcina extrauterin=. O. Cerne\chi ............................................................. 247 CAPITOLUL IX Supramaturitatea. Gh. Paladi ........................................................................ 267 CAPITOLUL X Retardul de dezvoltare intrauterin= al f=tului. Gh. Paladi, C. Iliadi - Tulbure ............................................................................. 273 CAPITOLUL XI Infec\ia materno-fetal= [i sarcina. O. Cerne\chi, T. E[anu .................... 294 CAPITOLUL XII Sarcina oprit= ]n evolu\ie. Moartea antenatal= a f=tului. Gh. Paladi, U. Tabuica .......................................................................................... 323 CAPITOLUL XIII Patologia chirurgical= ]n sarcin= ............................................................................ 334 12 GH. PALADI, OLGA CERNECHI Abdomen acut chirurgical ]n timpul sarcinii. E. Gu\u ............................. 334 Tromboza ]n sistemul venei cave inferioare ]n timpul sarcinii [i perioadei post-partum E. Gu\u, D. Casian ........... 351 CAPITOLUL XIV Tumorile benigne [i maligne ale organelor genitale [i sarcina. Gh. Paladi ............................................................................................................... 365 CAPITOLUL XV Hemoragiile obstetricale. Gh. Paladi, S. Hodorogea ............................... 382 CAPITOLUL XVI Na[terea indus=. Gh. Paladi .......................................................................... 432 CAPITOLUL XVII Patologia activit=\ii contractile a uterului. Gh. Paladi, Ia. Metaxa ..... 439 CAPITOLUL XVIII Distociile canalului osos. Gh. Paladi, T. E[anu .......................................... 476 CAPITOLUL XIX Macrosomia fetal=. Dispropor\ia feto-pelvin=. U. Tabuica .................... 494 CAPITOLUL XX Prezenta\iile pelviane a f=tului. Gh. Paladi, T. E[anu .......................... 501 CAPITOLUL XXI Anomaliile de prezenta\ie [i pozi\ie a f=tului. T. E[anu ......................... 533 CAPITOLUL XXII Opera\ii obstetricale, folosite pentru terminarea rapid= a na[terilor. O. Cerne\chi, T. E[anu ........................................................................................ 546 CAPITOLUL XXIII Opera\ia cezarian=. Gh. Paladi ..................................................................... 565 CAPITOLUL XXIV Traumatismul obstetrical. Gh. Paladi, L. Catrinici ................................... 582 CAPITOLUL XXV Infec\ia puerperal-septic=. V. Luca ............................................................. 604 CAPITOLUL XXVI St=rile critice ]n obstetric=. Gh. Paladi, U. Tabuica ................................ 657 CAPITOLUL XXVII Resuscitarea nou-n=scutului. Z. S`rbu ....................................................... 688 CAPITOLUL XXVIII Reproducerea asistat=. V. Mo[in .................................................................. 707 CAPITOLUL XXIX Aspecte psihologice ale obstetricii contemporane. Gh. Paladi, L. Stavinskaia .................................................................................. 718 Indice ............................................................................................................................. 731 OBSTETRIC PATOLOGIC 13 TABLE OF CONTENTS Preface ........................................................................................................................ 19 CHAPTER I Extrauterine pathology associated in pregnancy ................................................. 23 Generalities ............................................................................................................... 23 Pathology of cardiovascular system. Gh. Paladi, N. Cuco[ ....................... 24 Pathology of respiratory system. U. Tabuica ............................................... 39 Liver pathology. O. Cerne\chi ......................................................................... 49 Urinary tract disease. O. Cerne\chi ................................................................ 54 Endocrinophaties. Gh. Paladi ........................................................................... 62 Obesity. Gh. Paladi ............................................................................................. 76 Antiphosfolipid syndrome. Gh. Paladi ........................................................... 78 Ocular pathology. O. Cerne\chi, U. Tabuica ................................................ 87 Hematologic pathology. Gh. Paladi ................................................................ 91 CHAPTER II Nausea and vomiting during pregnancy. Gh. Paladi, U. Tabuica ........ 116 CHAPTER III Hypertensive disorders in pregnancy. Gh. Paladi, S. Hodorogea ......... 121 CHAPTER IV Rh isoimmunization. O. Cerne\chi ................................................................ 155 CHAPTER V Prematurity. O. Cerne\chi ............................................................................... 177 CHAPTER VI Pathology of fetal annexes. Gh. Paladi, U. Tabuica ................................. 190 CHAPTER VII Gestational trophoblastic diseases. U. Tabuica, C. Iliadi-Tulbure ....... 223 CHAPTER VIII Extrauterine pregnancy. O. Cerne\chi .......................................................... 247 CHAPTER IX Postterm pregnancy. Gh. Paladi .................................................................... 267 CHAPTER X Intrauterine growth restriction. Gh. Paladi, C. Iliadi-Tulbure ............... 273 CHAPTER XI Maternal and fetal infection in pregnancy. O. Cerne\chi, T. E[anu .. 294 CHAPTER XII Intrauterine fetal death. Gh. Paladi, U. Tabuica ......................................... 323 CHAPTER XIII Surgical pathology in pregnancy .............................................................................. 334 Acute abdomen during pregnancy. E. Gu\u ............................................... 334 Vein thrombosis in cava system in pregnancy and post-partum. E. Gu\u, D. Casian .................................................................................................. 351 14 GH. PALADI, OLGA CERNECHI CHAPTER XIV Benign and malign genital tumours and pregnancy. Gh. Paladi .......... 365 CHAPTER XV Obstetrical haemorrage. Gh. Paladi, S. Hodorogea .................................. 382 CHAPTER XVI Induced labor. Gh. Paladi ............................................................................... 432 CHAPTER XVII Uterine contractility activity pathology. Gh. Paladi, Ia. Metaxa ......... 439 CHAPTER XVIII Anatomical narrow pelvis. Gh. Paladi, T. E[anu ....................................... 476 CHAPTER XIX Fetal macrosomia. Feto-pelvian disproportion. U. Tabuica .................... 494 CHAPTER XX Breech presentation. Gh. Paladi, T. E[anu ................................................ 501 CHAPTER XXI Fetal presentation and position anomalies. T. E[anu .............................. 533 CHAPTER XXII Obstetrical operations. O. Cerne\chi, T. E[anu ........................................ 546 CHAPTER XXIII Caesarean section. Gh. Paladi ........................................................................ 565 CHAPTER XXIV Obstetrical traumatism. Gh. Paladi, L. Catrinici ........................................ 582 CHAPTER XXV Puerperal-septical infection. V. Luca ........................................................... 604 CHAPTER XXVI Critical states in obstetrics. Gh. Paladi, U. Tabuica ................................. 657 CHAPTER XXVII Newborn resuscitation. Z. S`rbu ................................................................... 688 CHAPTER XXVIII Assisted reproduction. V. Mo[in ................................................................... 707 CHAPTER XXIX Psychological aspects of contemporary obstetrics. Gh. Paladi, L. Stavinskaia .................................................................................. 718 Index ................................................................................................................................. 731 OBSTETRIC PATOLOGIC 15 ABREVIERI A variaia frecvenei medii AA apendicit acut AB astm bronic Ac anticorpi ACTD actinomicina-D ACTH hormonul adrenocorticotrop ADF adenozindifosfat ADH hormonul antidiuretic ADN acid dezoxiribonucleic AF anemie ferodefcitar AFL antifosfolipidic AFS antifosfolipidic sindrom Ag antigen ALL leucemie acut limfocitar ALT alanin-aminotransferaz AML leucemie acut mieloblastic AOC anamnez obstetrical complicat AP abruptio placentae ARN acid ribonucleic ASCCM American Society of Critical Care Medicine AST aspartat-aminotransferaz ATF adenozintrifosfat AT-III antitrombin-III ATP aport insufcient de energie ATS antitiroidiene de sintez BA bronit acut BC bronit cronic BCF btile cordului fetal BIP boal infamatorie pelvin BL bilirubin BPCO bronhopneumonie cronic obstructiv BTG boala trofoblastic gestaional BTP boala trofoblastic persistent C grade Celsius CA 1. circumferin abdominal; 2. colecistit acut Ca++ calciu CC 1. cardiopatii congenitale; 2. circumferina cranian; 3. coriocarcinom CCU cancerul colului uterin CGM cancerul glandei mamare Ch tratament chirurgical CID-sindrom sindromul de coagulare intravascular diseminat Cl clor CM cardiomiopatii cm centimetru CMV citomegalovirus CO 1. cancerul ovarian; 2. cordonul ombilical COC contraceptive orale combinate CT Chlamydia trachomatis CTG cardiotocografe D variaia frecvenei telediastolice DBP diametru biparietal DP depresie postnatal DZG diabetul zaharat gestaional ECG electrocardiografe 16 GH. PALADI, OLGA CERNECHI EDRF factorul endotelial relaxant ELISA Enzyme Linked Immunosorbent Assay FA 1. acid folic; 2. fosfataza alcalin FIGO Federaia Internaional de Ginecologie i Obstetric FIV fertilizare in vitro FSH hormonul foliculostimulant g gram g/l gram /litru g/or gram /or G-6-PD glucozo-6-fosfataz GINA Global Initiative in Asthma GN glomerulonefrit gr., Gr. grad Gy gray H nlime h or H 2 O ap HAV hepatit viral A Hb hemoglobin HbS hemoglobina drepanocitelor HBV hepatit viral B hCG, HGC hormonul gonadotropin corionic HCV hepatit viral C HDV hepatit viral delta HELLP sindrom - Hemolysis - hemoliz, Elevated Liver enzymes - activitatea mrit a enzimelor hepatice, Low Platelet count - trombocitopenie HIV/SIDA virusul imunodefcienei umane dobndite HLA human leukocyte antigen hLP hormonul lactogenul placentar HP hemoragiile post-partum HPV infeciile cu papilomavirus Ht hematocrit HTA hipertensiunea arterial I infuzie lichidian IC indicele de conductan placentar ICSI injectarea intracitoplasmatic a spermatozoizilor ID diastolic IG imunoglobulin IL interleuchin ILA indicele de lichid amniotic ImI indicele de impendan (Erskine- Ritchie) IP indicele de pulsalitate (Gosling) IR indicele de rezisten (Pourcelot) IRA insufcien renal acut IRC insufcien renal cronic IRVA infecie respiratorie viral acut I indicele de oc ISD indicele Stuart Drumm K+ kaliu, potasiu kcal/kg kilocalorii /kilogram kcal/zi kilocalorii /zi kg kilogram L lecitin l litru LA lichid amniotic LB litiaz biliar LCC lungimea cranio-caudal LDL low-density-lipoprotein, lipoproteine de densitate joas LES lupus eritematos de sistem (sistemic) OBSTETRIC PATOLOGIC 17 LF lungimea femurului LH hormon luteinizant LLC leucemie cronic limfocitar LMC leucemie cronic mieloid LMWH preparate heparinice cu greutate molecular mic LP lactogen placentar LTN leziunile trofoblastice neclasifcate M mas m milimetru cg microgram MESA aspiraia microepididimal a spermatozoizilor sub controlul microscopului mg miligram mg /zi miligram /zi mg% miligram% mg/kg/min miligram /kilogram /minut MgSO4 sulfat de magneziu MH mola hidatiform MHC mola hidatiform complet MHP mola hidatiform parial MI mola invaziv min minut MIUF moartea intrauterin a ftului Ml, mL mililitru Mm Hg milimetri ai coloanei de hidrargium (mercur) mmol/l milimoli /litru MODS sindromul de disfuncie organic multipl MST maladiile sexual transmisibile MTX metotrexat MU miom uterin Na+ natriu NH National Institute of Health nm nanometru NO oxid de azot NP natere prematur NVG nauseea i voma gravidelor NYHA New York Heart Association O2 oxigen OA oligoamnios OC operaie cezarian OI ocluzie intestinal OMS Organizaia Mondial a Sntii P 1. perfuzie; 2. pomp cardiac PA pancreatit acut PCO2 presiunea parial a bioxidului de carbon PCR reacia de polimerizare n lan PESA aspiraia epididimal percutanee cu ajutorul unui ac subire PG, Pg 1. prostaglandin; 2. fosfatidilglicerol PGE1 gemeprost, misoprostol (cytotec) PGE2 dinoproston, prepidil PH polihidramnios Ph tratament medicamentos; medicaie PI fosfatidilinosit PIF proflul indexului de frecven (Campbell) PLAP fosfataz alcalin placentar PNA pielonefrit acut PNC pielonefrit cronic pO2 presiunea parial a oxigenului PP 1. placenta praevia; 2. prezentaie pelvian; 3. psihoz postnatal PTU propiltiouracil 18 GH. PALADI, OLGA CERNECHI PVC presiune venoas central PVM pung vertical maxim PVN per vias naturalis rad razi RD retinopatie diabetic RDIU retardul de dezvoltare intrauterin a ftului Rh factor rezus RMN rezonan magnetic nuclear RPMA ruperea prematur a membranelor amniotice RU 486 mifepriston, mifprex s, sec. secund S 1. sfngomielin; 2. variaia frecvenei sistolice maxime; 3. terapie specifc SAFL sindrom antifosfolipidic spt. sptmni SBF scorul biofzical SCN sistemul nervos central SGB streptococul grupei B SHBG sex hormone binding globulin SI segment inferior sol. soluie SRIS sindromul de rspuns infamator sistemic beta STH hormon somatotrop Strp. streptococ T3 triiodtironin T4 tiroxin TA tensiune arterial T-AT-III trombin-antitrombin-III TBA albumin TBG thyroid binding globulin, globulin TBPA prealbumin TC tomografe computerizat TEAP tromboembolia arterei pulmonare TNS testul non-stres TO tumori ovariene TP tuberculoz pulmonar TTPA timp tromboplastinic parial activat TTSP tumoare trofoblastic de sit placentar TVP tromboza venelor profunde UA unitate de aciune UI unitate internaional USG ultrasonografe V ventilaie VDRL Veneral Disease Research Laboratories VEC versiunea extern cefalic VG vrst de gestaie/gestaional VHS virusul Herpes Simplex VLA volumul lichidului amniotic VSC volumul sngelui circulant VSH viteza de sedimentare a hematiilor X cromozomul X Y cromozomul Y -hGC subunitatea beta a hormonului gonadotropin corionic -globuline gama-globuline lungimea de und g /dl microgram /decilitru g /zi microgram /zi OBSTETRIC PATOLOGIC 19 PREFA S
arcina i naterea ntotdeauna au fost privite ca un proces fziologic. n acelai timp au avut i un impact pozitiv esenial n acest proces dezvoltarea rapid a tiinei medicale, inclusiv a obstetricii, perfecionarea formelor organizatorice, implementarea noilor metode de diagnostic i trata- ment. Cu toate acestea, sarcina i naterea prezint uneori un risc sporit pentru sntatea mamei i a copilului. n lume, sunt nregistrate anual peste 130 mln. de nateri, pierderile reproductive anuale constituind 500 000 de decese materne i 6 mln. de decese perinatale drept consecin a unor cauze cu infuen direct sau indirect. Riscul de deces variaz de la 1:20 n rile n curs de dezvoltare vis-a-vis de 1:10000 n majoritatea rilor industrial dezvoltate. Analiza deceselor materne i perinatale denot c multe din aceste viei ar f putut f salvate dac realizrile tiinei medicale i practice ar f fost im- plementate la timp i aplicate judicios. Or, se tie c utilizarea neraional a tehnologiilor noi poate duce la apariia unor complicaii cu consecine grave att pentru mam, ct i pentru ft. n anul 2006 a ieit de sub tipar volumul I al manualului de Obstetric, Bazele obstetricii fziologice. Prezenta lucrare este consacrat patologiei obstetricale i prezint volumul II al acestui manual. El conine 29 capitole viznd toate formele patologice ale obstetricii. La expunerea materiei au fost folosite experiena autorilor i rezultatele tiinei din ultimii ani nu numai n domeniul obs- tetricii, dar i al altor discipline medicale fr de care ar f imposibil dez- voltarea acesteia. n manual sunt expuse cele mai raionale forme de conduit a sarcinii i naterii n caz de gestoze tardive, retard de dezvoltare intrauterin a ftului, prezentaii fesiere, ruperea prenatal a pungii amniotice, macrosomie fetal; sunt prezentate procedeele de resuscitare a nou-nscutului, aa-zisele pa- tologii care pe parcursul ultimelor decenii au fost obiectul unor discuii am- ple. De pe poziii noi este elucidat problema operaiei cezariene. n acest volum au fost incluse capitole noi fa de alte manuale, cum ar f: patologia chirurgical n sarcin, sarcina medical asistat, aspecte psi- hologice n obstetric, tumorile benigne i maligne ale organelor genitale feminine i sarcina. 20 GH. PALADI, OLGA CERNECHI Pentru facilitarea nsuirii materiei, manualul este nzestrat cu un bogat material ilustrativ (grafce, tabele) i algoritme de conduit. Dezvoltarea tiinei medicale cere revizuirea periodic a programelor de studiu universitare i la compartimentul obstetric. Un rol important n pregtirea specialitilor n cadrul universitii aparine programelor de pregtire a studenilor i rezidenilor. Ele necesit s fe permanent revzute n conformitate cu progresul tiinei medicale. Sperm c acest volum va rspunde interesului i necesitilor de instruire ale noii generaii de studeni, rezideni, medici de familie i va oferi soluii efciente n domeniul obstetricii contemporane orientate spre mbuntirea indicatorilor sntii reproductive. Gh. PALADI OBSTETRIC PATOLOGIC 21 PREFACE P regnancy and birth have always been considered as a physiological process. Unfortunately, in spite of the quick development of the medical science, including obstetrics, improvement of the organization, implementation of the new methods of diagnostics and treatment, up to present time pregnancy and birth present a high risk for the health of mother and child. Each year more than 130 million births are registered worldwide, but annual reproductive losses constitute 500 000 maternal births and 6 million perinatal deaths as a consequence of the causes of direct and indirect infuence. The risk of death differs from 1:20 in the developing countries and 1:10000 in the majority of the industrial developed countries. The analysis of the maternal and perinatal deaths denotes that many of these lives could be saved, if the achievements of the medical science and practice would be have been implemented duly and used rationally. However, irrational use of the new technologies can lead to the appearance of complications with the serious complications both for the mother and the fetus. In 2006 Basics of Physiological Obstetrics Vol. I was published. Volume II is devoted to the obstetrical pathology and contains 27 chapters, comprising all pathological forms of obstetrics. The authors experience and the science results of the recent years not only in obstetrics, but in the other medical disciplines, without which the further development of this discipline would be impossible, have been applied. The manual describes the most rational forms of pregnancy and birth behavior in the case of tardive gestosis, retard in the fetus intrauterine development, breech delivery, prenatal rupture of the amniotic sac, fetal macrosomia, resuscitation of the new born child, so-called pathologies, which were subject to numerous discussions in the recent decades. The problem of the cesarean operation has been elucidated from the new points of view. This volume includes new chapters, such as surgical pathology in pregnancy, medically assisted pregnancy, psychological aspects in obstetrics, benign and malign tumors of the female genital organs and pregnancy. To facilitate studying of the material, the manual comprises the rich illustrative material (graphs, tables) and the behavior algorithms. 22 GH. PALADI, OLGA CERNECHI The development of the medical science demands further revision of obstetrics in the university curricula. The curricula of students and residents training play an import role in the training of specialists at the university. They need to be renewed permanently in accordance with the progress of the medical science. We hope that this volume responds to interest and needs of the new generation of students, residents, family doctors and meets the requirements of the modern obstetrics oriented to the improvement of the reproductive health indexes. Gh. PALADI