PATOLOGIA FICATULUI

HEPATIC PATHOLOGY

Morfologia normal a ficatului:

a aspect macroscopic; b aspect pe seciune; c - structura microscopic a lobulului hepatic portal (zonele 1, 2 i 3)

Pattern of Liver Damage

Zonal Toxin/Hypoxia Bridging Viral severe Interface Immune Apoptotic - Viral

Steatoza ficatului

Necroz masiv a ficatului (distrofie toxic)

Acute - Hepatitis - Chronic

Hepatit alcoolic,

steatoz i corpusculi Mallory

Alcoholic Liver Damage

Hepatit viral,
distorfie hidropic i corpusculi Councilman , infiltraia limfoid a tractelor portale (necroz periportal parcelar)

 Hepatocite de sticl mat cu citoplasma omogenizat (acumulri

masive de HBsAg)

Ground glass hepatocytes with homogenous cytoplasm (massive accumulation of HBsAg)

Fragmente

rotunde eozinofile de hepatocite apoptozice corpusculi

Councilman Rounded eosinophil fragments of apoptotic hepatocyte Councilman bodies

d b

Ciroz macro- (a, b) i micronodular (c, d)

Ciroz hepatic,
aspecte microscopice

Dilatarea varicoas a venelor esofagiene

i peretelui abdominal anterior

Jaundice

Splenomegalie

Calculi i staz biliar n ficat

Carcinom hepatic nodular

Carcinom hepatic hepatocelular,

structuri trabeculare

Metastaze de carcinom n ficat