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01 - 02 Interactiuni de Tip Farmacocinetic
01 - 02 Interactiuni de Tip Farmacocinetic
Prof. Dr. Catalina Elena Lupusoru, sef lucr. Dr. Cristina Ghiciuc
An universitar 2010-2011
unii hormoni (de exemplu, steroizii anabolizan i); hidrocarburi cancerigene, ca: 3,4-benzpirenul, 3-metilcolantrenul; altele: Spironolactona, etanolul, nicotina. Inhibitoare ale enzimelor metabolizatoare hepatice: (cp 27, 424, 444, 635, 903) Allopurinol (uricostatic); Cimetidin (blocant al receptorilor histaminergici H2); Ketoconazol (antifungic); Fenilbutazon (antiinflamator nesteroidian); chimioterapice antibacteriene (Sulfonamide, Metronidazol, Cloramfenicol, Izoniazid, Eritromicin, Claritromicin); antipsihotice inhibitoare selective ale recaptrii serotoninei (Sertralina, Fluoxetina); Disulfiram (inhibitor al alcooldehidrogenazei). 4. La nivelul eliminrii Probenecid ntrzie eliminarea Penicilinei G, a Indometacin, sulfonamide antidiabetice, Metotrexat, deriva i ioda i, prin competi ie pentru acelai transportor tubular renal de secre ie tubular. (cp 29, 530) Penicilina G competi ioneaz cu Acidul acetilsalicilic la mecanismul de secre ie tubular renal i scade efectul uricozuric al acestuia. (cp 490) Blocantele receptorilor histaminergici H2 inhib clearance-ul renal al medicamentelor bazice secretate de tubii renali (Procainamida). (cp 444) Prin alcalinizarea urinii: Acetazolamida crete eliminarea de salicila i i crete eliminarea complexelor formate de agen ii chelatori cu metalele grele. (cp 490) Prin acidifierea urinii: Clorura de amoniu scade eliminarea salicila ilor. (cp 490) Bibliografie
1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. Cristea Aurelia Nicoleta, Tratat de farmacologie, editia I, Editura Medical, 2007. Fulga I, Farmacologie, Editura Medical Buciureti, 2004. Goodman Gilman A. The Pharmacological Basis of Therapeutics, 9th edition, McGrawHill, 2005. Katzung B.G. Basic&Clinical Pharmacology. 8th edition, Lange Medical Book, 2001. Lupuoru Ctlina Elena. Imunofarmacologie, Ed. Alfa, Iai, Romania, 2001. Lupuoru Ctlina Elena, Cristina Mihaela Ghiciuc. Farmacologia n comprimate Editura Alfa, 2009. Lupuoru Ctlina Elena, Cristina Mihaela Ghiciuc, Liliana Tar u. (editors) New pathophysiological challenges and pharmacological approaches. Ed. Junimea, 2009. Lupuoru Ctlina Elena, Liliana Tar u. (editors) Adverse effects of pharmcologic active substances: from bench to bedside. Ed. Junimea, 2009. Lupuoru Ctlina Elena. Farmacologie vol I, II, III Editura Moldova Iai. 1994. Mircioiu Constantin, Miron Dalia, Radulescu Flavian, Ghiciuc Cristina, Mircioiu Ion Elemente de biofarmacie i farmacocinetic, Ed. Universitar Carol Davila, 2008 Rang and Dale, Parmacology, 5th edition, 2003. Roach Sally. Pharmacology for health professionals, Lippincott Williams and Wilkins, 2005. Stroescu V. Bazele farmacologice ale practicii medicale vol I. Editura medical 1988. Tica A. Voicu V.A Farmacologie. Editura Medical Universitar. 2004. Voicu V, Macovei M, Miclea L. Ghid de toxicologie clinic, Ed. Medical AMALTEEA, 1999. Voicu V., Mircioiu C. Mecanisme farmacologice la interfe e membranare interac iuni finite medicamente interfe e biologice, Ed. Academiei Romne, 1994. Voicu V.A. Toxicologie clinic, Ed. Albatros, Bucureti, 1999.
Prof. Dr. Catalina Elena Lupusoru, sef lucr. Dr. Cristina Ghiciuc
An universitar 2010-2011
Prof. Dr. Catalina Elena Lupusoru, sef lucr. Dr. Cristina Ghiciuc
An universitar 2010-2011
18. 19. 20. 21. 22. 23. 24. 25. 26. 27. 28. 29. 30. 31. 32. 33. 34.
Gallamina este n rela ie de antagonism alosteric cu acetilcolina pe receptorii muscarinici M2 cardiaci. (cp 65) Noradrenalina/adrenalina i histamina sunt n rela ie de antagonism fiziologic la nivel vascular. (cp 65) Crbunele activat este n rela ie de antagonism fizic cu molecule din anumite toxice, deoarece le adsoarbe pe suprafa a sa. (cp 65) Antiacidele sunt n rela ie de antagonism chimic cu HCl gastric. (cp 65)
Bibliografie
Cristea Aurelia Nicoleta, Tratat de farmacologie, editia I, Editura Medical, 2007. Fulga I, Farmacologie, Editura Medical Buciureti, 2004. Goodman Gilman A. The Pharmacological Basis of Therapeutics, 9th edition, McGrawHill, 2005. Katzung B.G. Basic&Clinical Pharmacology. 8th edition, Lange Medical Book, 2001. Lupuoru Ctlina Elena. Imunofarmacologie, Ed. Alfa, Iai, Romania, 2001. Lupuoru Ctlina Elena, Cristina Mihaela Ghiciuc. Farmacologia n comprimate Editura Alfa, 2009. Lupuoru Ctlina Elena, Cristina Mihaela Ghiciuc, Liliana Tar u. (editors) New pathophysiological challenges and pharmacological approaches. Ed. Junimea, 2009. Lupuoru Ctlina Elena, Liliana Tar u. (editors) Adverse effects of pharmcologic active substances: from bench to bedside. Ed. Junimea, 2009. Lupuoru Ctlina Elena. Farmacologie vol I, II, III Editura Moldova Iai. 1994. Mircioiu Constantin, Miron Dalia, Radulescu Flavian, Ghiciuc Cristina, Mircioiu Ion Elemente de biofarmacie i farmacocinetic, Ed. Universitar Carol Davila, 2008 Rang and Dale, Parmacology, 5th edition, 2003. Roach Sally. Pharmacology for health professionals, Lippincott Williams and Wilkins, 2005. Stroescu V. Bazele farmacologice ale practicii medicale vol I. Editura medical 1988. Tica A. Voicu V.A Farmacologie. Editura Medical Universitar. 2004. Voicu V, Macovei M, Miclea L. Ghid de toxicologie clinic, Ed. Medical AMALTEEA, 1999. Voicu V., Mircioiu C. Mecanisme farmacologice la interfe e membranare interac iuni finite medicamente interfe e biologice, Ed. Academiei Romne, 1994. Voicu V.A. Toxicologie clinic, Ed. Albatros, Bucureti, 1999.
Prof. Dr. Catalina Elena Lupusoru, sef lucr. Dr. Cristina Ghiciuc