UNIVERSITATEA DIN ORADEA

FACULTATEA DE MEDICINĂ ȘI FARMACIE

DOMENIUL / PROGRAMUL DE STUDIU ZI

FORMA DE ÎNVĂŢĂMÂNT CU FRECVENȚĂ

LUCRARE DE LICENȚĂ

COORDONATORI ŞTIINŢIFICI

Dr. SZILÁGY ARIANA

ABSOLVENT

PESLARI ALINA-ANDREEA

ORADEA

2019

CUPRINS
Introducere ..................................................................................Error! Bookmark not defined.
I. Icterul fiziologic al nou născutului .........................................Error! Bookmark not defined.
1.1. Date generale ..................................................................Error! Bookmark not defined.
1.2. Particularitățile metabolismului bilirubinei la nou născut ............ Error! Bookmark not
defined.
1.3. Diagnostic paraclinic ......................................................Error! Bookmark not defined.
1.4. Factori de risc .................................................................Error! Bookmark not defined.
1.5. Tratament ........................................................................Error! Bookmark not defined.
II. Ictere patologice .....................................................................Error! Bookmark not defined.
2.1. Date generale ..................................................................Error! Bookmark not defined.
2.2. Clasificarea icterelor patologice .....................................Error! Bookmark not defined.
III.Ictere prin hiperproductie de bilirubină .............................Error! Bookmark not defined.
3.1 Icterul hemolitic prin izoimunizare Rh ...........................Error! Bookmark not defined.
3.1.1 Fiziopatologie ...........................................................Error! Bookmark not defined.
3.1.2. Anatomie patologică ................................................Error! Bookmark not defined.
3.1.3. Factorii care condiţionează izoimunizarea ...............Error! Bookmark not defined.
3.1.4. Manifestări clinice ...................................................Error! Bookmark not defined.
3.1.5. Profilaxia izoimunizării Rh ......................................Error! Bookmark not defined.
3.1.6. Diagnostic paraclinic................................................Error! Bookmark not defined.
3.1.7. Tratament .................................................................Error! Bookmark not defined.
3.2. Icterul hemolitic prin izoimunizare ABO. ......................Error! Bookmark not defined.
3.3. Alte ictere hemolitice neonatale .....................................Error! Bookmark not defined.
3.3.1. Deficit de glucozo-6-fosfat-dehidrogenază eritrocitară (G6PD) .. Error! Bookmark
not defined.
3.3.2. Sferocitoza ereditară ...............................................Error! Bookmark not defined.
IV.Icter prin amplificarea circulației enterohepatice ..............Error! Bookmark not defined.
4.1. Icterul laptelui matern .....................................................Error! Bookmark not defined.
4.2. Icterul prin obstrucția tubului digestiv ...........................Error! Bookmark not defined.
V.Icter produs prin scăderea clearance-ului bilirubinei .........Error! Bookmark not defined.
5.1. Boala Crigler-Najjar tip 1 (CN 1) ..................................Error! Bookmark not defined.
5.2. Boala Crigler-Najjar tip 2 (CN 2) ..................................Error! Bookmark not defined.
5.3. Boala Gilbert ..................................................................Error! Bookmark not defined.
VI.Tratamentul hiperbilirubinemiei indirecte neonatale ........Error! Bookmark not defined.
6.1.Fototerapia ......................................................................Error! Bookmark not defined.
6.2.Exsanguinotransfuzia ......................................................Error! Bookmark not defined.
6.3.Alte metode de tratament .................................................Error! Bookmark not defined.
VII.Ictere neonatale cu bilirubină directă (icter colestatic) ....Error! Bookmark not defined.
7.1.Etiologie...........................................................................Error! Bookmark not defined.
 7.2. Manifestări clinice ......................................................... Error! Bookmark not defined.
7.3. Examene paraclinice .......................................................Error! Bookmark not defined.
7.4. Anatomie patologică .......................................................Error! Bookmark not defined.
7.5. Tratament ........................................................................Error! Bookmark not defined.
7.6. Cauze rare de icter colestatic ..........................................Error! Bookmark not defined.
7.6.1. Deficitul de α-1-antitripsină .....................................Error! Bookmark not defined.
7.6.2. Chist de coledoc .......................................................Error! Bookmark not defined.
VIII.Icter nuclear ........................................................................Error! Bookmark not defined.
Bibliografie ...............................................................................Error! Bookmark not defined.