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Noiuni de Optogenetic
Ce este Optogenetica?
Optogenetics is the combination of genetic and
optical methods to achieve gain or loss of function
of well-defined events in specific cells of living
tissue.
(K. Deisseroth, Optogenetics, Nature Methods , Dec 2010, 2629)
Scurt istoric:
1979 - Francis Crick : o provocare major n
neurotiine controlul asupra unui
anumit tip de celule, n timp ce restul nu
sunt pertrurbate manipularea luminii n
acest scop.
(Karl Deisseroth, Optogenetics, Nature Methods , Dec 2010)
Principii:
http://sitemaker.umich.edu/behnazj.notes/list_by_behnaz_jarra
hi__college_of_engineering _
http://www.etudogentemorta.com/wp-content/uploads/2010/05/optogenetics.jpg
1.
2.
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4.
5.
SPECIFICITATE CELULAR
PRECIZIE SPAIAL
PRECIZIE TEMPORAL (ms)
CONTROL BIDIRECIONAL
CONTROL CAUSAL
ofer
precizie
temporal
Loss of
function /Gain
of function
Stimular
nu are
easelectivitat
electric
e celular
timp de
Metodele
procesare
genetice
mare(ore,zile,l
traditional
euni)
Prin comparaie :
specificitate
celular
timp de
procesare
relativ mare
Farmacoefecte
adverse
terapia
(K. Deisseroth,Optogenetics: Controlling the Brain with Light , Scientific American, Dec 2010)
OPTOGENETICA- METODA
ANULUI
2010
Nature Methods'choice of
Method of the Year 2010 is
optogenetics for its capacity to
control cell function with light.
(http://www.nature.com/nmeth/focus/moy2010/index.html)
Aplicaiile Optogeneticii
o Afeciuni neuro-psihiatrice
- tratamentul narcolepsiei Hypocretin
Cells -blocarea mecanismului de trezire
(K. Deisseroth,Optogenetics: Controlling the Brain
with Light , Scientific
American, Dec 2010 )
- Schizofrenie parvalbumin
modularea undelor Gamma
(K. Deisseroth,Optogenetics: Controlling the Brain with Light ,
Scientific American, Dec 2010)
Light ,
Scientific American, Dec 2010)
http://nmbl.stanford.edu/research/experiments/optogenetics.htm
CONCLUZII
instrument de cercetare
viabil
OPTOGENET
ICA
metoda nou
extindere
alternativ terapeutic n
diverse afeciuni
http://news.discovery.com/tech/photo-first-lights-captured-as-both-particleand-wave-150302.htm