4.1 Inhibitori ai intrarii virusului in celula 4.2 Inhibitori ai sintezelor virale intracelulare 4.

are 4.3 Inhibtori ai asamblarii componentelor virale si ai eliberarii

virusului
4.1.1 Inhibitori ai adsorbtiei si penetrarii A) Inhibitori ai sintezelor proteice precoce, nestructurale : Guanidina, 4.3.1 Inhibitor de neuraminidaza: Zanamivir, Oseltamivir ( Virus
Gama-globulina Hidroxibenzilbenzimidazol gripal A si B)
Amantadina B) Inhibitori ai sintezelor de acizi nucleici 4.3.2 Alti inhibitori : 5 fluoro 2- deoxiuridina
Rimantadina ( Gripal A) Analogi nucleozidici 4.3.3 Antagonisti ai receptorilor pentru chemokine
Disoxaviril ( poliomielitic , Coxackie, rinovirus) a) Inhibitori ai ARN-polimerazei virale/AND polimerazei 4.3.4 Antiintegraze
Ribavirin ( Gripal A si B, respirator sincitial, hepatic, Hiv)
Sorivudine ( Varicela -zoster, Ebv, herpes 1 si 2)
Trifluridina

b) Inhibitori nucleozidici ai revers-transcriptazei retrovirusurilor ( HIV)

Zidovudina, Didanozina, Zalcitabina

c) Alti-analogi nucleozidici: Aciclovir, Valaciclovir, Penciclovir, Famciclovir, Ganciclovir

( Herpes , hepativ , EBV, citomegalic)
4.1.2 Inhibitori ai penetrarii in celula gazda
Inhibitori ai fuziunii a) Inhibitori nucleotidici de revers-transcriptaza: Tenofovir, Cidofovir (VHS 1 si 2, HPV,
Enfuvirtide ( HIV) adenovirusuri , poxvirusuri, citomegalo , varicelozosterian
Docosanol Virus herpes 1 b) Inhibitori nenucleozidici ai revers-transcriptazei retrovirusurilor: Nevirapina, Efavirenz,
Delavirdina ( Hiv)
c) Inhibitori de proteaza retrovirale: Saquinavir, Ritonavir, Indinavir ( HIV)
d) Inhibitori ai sintezelor proteice tardive : Fluorofenilalanina, Puromicina
e) Alti inhibitori ai sintezei acizilor nucleici : Acidul fosfonacetic, Azidotimidina

Antifungice
5.1 Poliene 5.2 Benzofuranone 5.3 Azoli 5.4 Alilamine 5.5 Alte structuri
Amfotericina B Griseofulvina 5.3.1 Imidazoli : Ketoconazol, Miconazol , Econazol Terbinafina Flucitozina
Natamicina Naftifin Caspofungina
Nistatin 5.3.2 Triazoli: Fluconazol, Itraconazol, Voriconazol, Bifonazol Tolnaftat

Antiparazitare
6.1 Tratamentul infectiilor cu protozoare 6.2 Tratamentul infectiilor cu helminit
A ) Amoebioza
Albendazol, Mebendazol, Tiabendazol
Diloxanid furoat
Metronidazol Bithlonol, Emetina, Ivarmectin
Tinidazol

B)Leishmanioza

Pentamidina
Stibogluconat de Na
Amfotericina B , Metronidazol

C)Malarie
Clorochina
Chinina
Pirimetamina
Primaquine
Halofantrina

D)Pneumocystoza: Atovaquone
E) Toxoplasmoza

Sulfonamide +Pirimetamina( de electie)

Cotrimoxazol

F) Trichomoniaza
Metronidazol, Tinidazol

G) Tripanosomiaza
Pentamidina
Stilbamidin