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C2 - Imunitatea Antivirala
C2 - Imunitatea Antivirala
INTERFERONI
Patern recognision receptors
Legati de membrana-Toll like receptors -TLR (premiul Nobel, 2011)
Citoplasmatici RIG-I- gena inductibila de acid retinoic (DEAD-box
protein 58 )- motivul conservat Asp-Glu-Ala-Asp (DEAD)- ARN
helicaza- implicata in legarea si alterarea structurii secundare a
ARN
PAMPs -pathogen-associated
molecular patterns
Sinteza de IFN
JAK- Janus kinase ( "Just another kinase") ;STAT -signal transducer and activator of transcription
ISGF3 -IFN-stimulated gene factor 3 (contine STAT1, STAT2 si un alt factor de transcriptie-IRF9
ISRE -IFN-stimulated response element ;ISGs -IFN-stimulated genes; GAS -gamma activated sequence
Epitopi conformationali
Epitopi liniari
ANTICORPI
MONOCLONALI
Bruce A. Beutler
The Scripps Research Institute,
La Jolla, CA, University of
Texas, Dallas, TX, USA
Rockefeller University,
New York, USA
Peter C. Doherty
Rolf M. Zinkernagel
Australia
Switzerland
University of Zurich,
Institute of Experimental
Immunology
Zurich, Switzerland
b. 1940
b. 1944
Th =CD4+- CMH II
ROLUL LIMFOCITELOR Th
Exist dou subseturi de celule Thelper, dupa profilul citokinelor sintetizate:
Th1 - IL2 si IFN gama- regleaza RI celular
Th2 - IL-4, IL-5, 6, 10- regleaza RI umoral
Ag
Ag
APC
Antigen-presenting cell
Ag
Th2
IL4, 5, 6, 10
B cell
Th1
IL2 + IFN gama
Tc
cell
Granulocyte
Macrophage
NK
NK cell
ROLUL LIMFOCITELOR Tc
Tc cell
Perforin
Ca++
polymerizes
Perforin
monomers
Tc cell
Polyperforin channels
Target cell
Target cell
Granzymes
LIMFOCITE T CITOTOXICE
Proteina TM ce apartine
familiei TNF
MACROPHAGE
IMUNITATE ANTIVIRALA-COOPERARE
tardiv, persistent,
anticorpii sintetizati sunt
de tip IgG , recunosc cu
mare specificitate un
anumit tip sau subtip de
virus.
RI primar
timpuriu, pasager,
anticorpii sintetizati
sunt de tip IgM, cu
afinitate redus fata
de virus
Memorie
imunologica=baza
vaccinarii
VACCINURI VIRALE
VACCINURI INACTIVATE
(ex: Vaccin antipolio inactivat -SALK 1952- administrare injectabila
ROMANIA
Calendarul de vaccinari valabil de la 1 decembrie 2008
Varsta recomandata
Vaccin
Comentarii
Primele 24 de ore
4-7 zile
HepB
BCG
In maternitate
2 luni
Simultan
4 luni
DTPa IPV
Simultan
6 luni
Simultan
12 luni
Simultan
4 ani**
DTPa
RRO
Campanii scolare
VPO
Campanii scolare
Campanii scolare
http://americanhistory.si.edu/polio/virusvaccine/index.htm
http://www.astdhpphe.org/infect/polio.html- polio facts- FAQ
http://www.nlm.nih.gov/medlineplus/polioandpostpoliosyndro
me.html
http://w3.whosea.org/EN/Section1226/Section1228.htm-
vaccin antipolio
http://www.post-polio.org/