Documente Academic
Documente Profesional
Documente Cultură
aspecte clinice
si imagistice
Bejan Marina
Conducator teza:
Definitie
Bronsiectazia(gr.bronkos-
tub;ektasis-dilatatie)
reprezinta o dilatatie
ireversibila si anormala a
bronsiilor de calibru
mediu,datorata distrugerii
componentelor elastice si
musculare ale peretelui
bronsic. Poate fi: locala,
interesand caile respiratorii
dintr-o regiune limitata a
parenchimului pulmonar,
sau difuza: cu o distributie
mai larga.
1808 - Profesorul Cayol observa prima data bronsiectazia
Bronsiectazia este o cauza majora de mortalitate si morbiditate in tarile subdezvoltate unde conditiile
economice sunt precare, vaccinurile impotriva infectiilor de tract respirator sunt rare, nu exista resurse
pentru a administra antibioticele adecvate in caz de infectii respiratorii si prevalenta TBC-ului
pulmonary este crescuta.
In decursul ultimelor decenii s-a inregistrat in Europa si America de Nord o scadere dramatica a cazurilor
de bronsiectazie, atribuita extensiei antibioterapiei si vaccinurilor profilactice. Aceste date au
consolidate ipoteza conform careia majoritatea bronsiectaziilor sunt dobandite postnatal si sunt in
stransa legatura cu infectiile bronhopulmonare severe ale copilariei (rujeola, tusea convulsive,
tuberculoza) si in acelasi timp au restrans aria bronsiectaziei congenitale, multa vreme supraevaluata.
Factorii genetici intervin in geneza unui grup relative redus de bronsiectazii.
Primele studii pe scara larga pentru a determina incidenta bronsiectaziilor a fost realizata in 1953 fiind
examinata populatia din Bredford,oras din Marea Britanie.Autorii au identificat o incidenta a
bronsiectaziilor de 1.3 la 1,000 populatie.
Studii mai recente realizate pe cohort in Finlanda,Noua-Zelanda si SUA.
Studiile din Finlanda arata o incidenta de 2,7 la 100.000;cele din Noua-Zelanda 3,7 la 100,000.
In SUA au fost realizate studii pe grupe de virste de pacienti ce estima prevalent de 4,2 la 100,000 la
persoanele ce au virsta cuprinsa intre 18-34 ani,si incidenta de 271,8 la 100,000 pentru pacientii cu
virsta >75 ani.
Etiologie
BRONCHIECTASIS
Broncholith
Retraction of parenchima
Obstruction by foreign body
Neoplastic obstruction
Cartilage deficiency
Cilia syndrome
Host defenses down(agammaglobulinemia)
Infection
Emphysema
Cystic fibrosis Chronic granulomatous disease
Tuberculosis
ABPA
Swyer-James syndrome
Inhalation injury(ammonia,gastric acid)
Sarcoidosis
Factori predispozanti
Ammonia
Chlorine
Nitrogen dioxide
Direct airway damage altering
structure and function
Cauze infectioase:
Infectii tuberculoase:
Fibroza cicatriciala, retractii, deformari bronsice, stenoze
cicatriciale
Congenitale:
Traheobronhomegalia
Sdr. Williams-Campbell (caracter familial):
Deficitul/absenta cartilajului bronsic
Dilatatii generalizate, dinamica bronsica mult alterata
Boala polichistica
Chisturi centrale (unice, nu comunica cu bronhia)
Chisturi periferice (multiple, pot afecta ambii plamani)
Sechestratia pulmonara
Congenitale:
Mucoviscidoza:
Este perturbata secretia mucusului traheobronsic
Bronhoreea vascoasa ingreuneaza drenajul si favorizeaza infectiile repetate
In final dilatatii bronsice
Sdr. Kartagener
Situs inversus + sinuzita + bronsiectazii
Sdr. Mounier-Kuhn
Sdr.Ehlers-Danlos
Deficit de alfa1-antitripsina
Hipogamaglobulinemie
Scaderea rezistentei la infectii bronsiectazii
Cauze obstructive:
Corpi straini
Tumori endobronsice benigne
Cancere bronsice
Bronsiectazii generalizate:
Bronsiectazii localizate:
Cu origine pulmonara
Cu plaman anterior normal Astm
Pneumonia stafilococica Infectie abcedata
Alte infectii abcedate Aspiratie gastrica
recurenta
Obstructia bronsica Inhalare de gaze corozive
Corpi straini, tumori, Cu origine sistemica
stenoze Fibroza chistica
Compresie extrinseca Diskinezie ciliara
Imunodeficiente umorale
La orice invazie bacteriana sistemul imun atit celular
cit si umoral reactioneaza promp pentru combaterea
agentului patogen
Fiziopatologie
Fenomene locale:
Alterarea mucoasei
Raspunsul inflamator al gazdei
Acumularea secretiilor purulente
Colonizarea bacteriana
Microorganismele:
Elibereaza endotoxine si enzime proteolitice
PMN activate de fagocitele agentilor infectiosi elibereaza proteaze
(elastaza neutrofilica) cu rol in intretinerea procesului inflamator al
mucoasei bronsice
Aceste procese impreuna cu elementul obstructiv elemente
patogenice in producerea dilatatiilor bronsice
Bronsiectazia determina:
Suprimarea tesutului pulmonar functional
Cresterea spatiului mort respirator
la nivelul dilatatiilor nu se face schimba gazos iar
alveolele tributare sunt hipoventilate
Debut:
Insidios
In majoritatea cazurilor
Bronsiectaziile neinfectate raman mute multa vreme
Acut:
Bronsita/viroza respiratorie tusea si expectoratia se accentueaza si se
instaleaza definitiv
Hemoptizii mici
1. Tuse cronica
2. Expectoratie purulenta
3. Febra
4. Astenia fizica
5. Scaderea ponderala
1. Expectoratia
Simptomul dominant
De multe ori abundenta, in procesele supurative pana la 500 ml/24ore (de
obicei 100-300 ml/zi)
Eliminata in special dimineata sau la schimbarea pozitiei (toaleta bronsica
matinala)
Aspect predominant purulent, se depoziteaza in vasul de colectare in 3
straturi:
Inferior (purulent) puroi, detritus celular
Mijlociu (mucos)
Superior (seros)
Inodora, poate deveni fetida daca se dezvolta germeni anaerobi in cavitati
mari
Contine germeni Gram + si Gram -
2. Tusea
Usoara sau persistenta
Intermitenta in cursul zilei
Suparatoare dimineata sau la schimbarea pozitiei
3. Hemoptizia
Frecventa (40-70% din cazuri)
Amploare variabila (sputa cu striuri sanguinolente
hemoptizii mari, grave, uneori fatale)
Ca urmare a necrozei epiteliului bronsic sau prin ruptura
anastomozelor dintre vasele bronsice si cele pulmonare
4. Dispneea
Relativ rara
La bolnavi cu forme extinse sau in cursul exacerbarilor
5. Pneumonii recidivante
Ca urmare a episoadelor inflamatorii
Imbogatirea semnelor locale:
Accentuarea dispneei
Febra
Alterarea starii generale
Diagnostic examen clinic
Imagistica prin rezonanta magnetica este o tehnic n evoluie, care ofer informaii att
structurale cit i funcionale.
Avantajul este lipsa de radiaii ionizante. Limitri includ costul, disponibilitatea i Rezoluia
spaial inferioar comparativ cu CT. Tehnica n continuare necesit evaluare, dar are
beneficiile poteniale de exemplu la pacientii cu CF.
Evaluare a clearance-ul mucociliary folosind scintigrafia radionuclid pot fi de valoare,
n special n dezvoltarea rezistentei la droguri.
Tomografia computerizata (HRCT) poseda o
sensibilitate de 84-97%
si specificitate de 82-99%,dar poate fi si mai mare la
centrele de sesizare.
Avantaje:noninvazivitatea ,evitarea posibilelor reactii
alergice la substanta de contrast .
Cele 3 forme de bronsiectazii n clasificarea Reid
pot fi vizualizate de HRCT.
Radiografia
]
In cazul bronsiectaziilor chistice:
Ciorchine de struguri:acest
semn tipic in bronsiectaziile de
tip sacciform apar intr-un
sindrom de condensare
retractil.
This high-resolution computed tomography scan in a 13-year-
old female adolescent shows left lower-lobe bronchiectasis,
which is secondary to tuberculosis.
In bronsiectaziile cilindrice :
Inel cu pecete:apare in momentul
cind raportul bronhoarterial
creste.Calibrul bronhiei si a vasului
adiacent in norma este de 1-
1,5;atunci cind bronhia depaseste
limita de 1,5 ia apare mai
dilatata(inelul)si vasul adiacent
(pecetele).
Diametrul bronhiilor adiacente
pleurei si mediastinului pot atinge
1cm dar e mai putin specifica.
Axial HRCT (lung window) shows a mosaic pattern. There is
central bronchiectasis with mucoid impaction in many of the
bronchiectatic cavities (thin arrow). Also seen are
centrilobular nodules in a tree-in-bud pattern (bold arrow)
Deget de
manusa:hiperdensitati ale
tesutului moale cu aspect de
ramificatii tubulare sau in
deget de manusa in forme de V
sau Y.Este dat de bronhiile
dilatate unplute cu
mucus(impact mucoid)
CT scan of thorax in a patient with IPF showing typical basal, sub-
pleural, honeycomb shadowing and traction bronchiectasis.
Harrison Cough 2013 9:9 doi:10.1186/1745-9974-9-9
Bronsiectazii varicoase
Sirag de margele:
Alternarea zonelor de dilatatie
bronsica cu zone de
constringere a diametrului
bronhiilor .
Commonly associated with bronchiectasis are the
following:
Bronchial thickening
Centrilobular nodularity related to bronchiolitis
Mucous plugging
Bronchial arterial dilatation
Air trapping
Volume loss or hyperinflation
Degree of confidence
Except for extremely obese patients and examinations compromised by motion,
volumetric imaging of the chest provides a very high degree of confidence to confirm
or deny the diagnosis of bronchiectasis. HRCT scanning has a sensitivity of 96% and a
specificity of 93%,[3] as compared with bronchography.
Bronchial measurements may vary with the use of different WLs and WWs.[19]
Some patients without bronchiectasis have a 1.49:1 bronchus-to-artery ratio; however,
the ratio is reliable only if it is greater than 1.5. If the ratio is less than 1.5, other signs,
such as bronchial wall thickening and lack of tapering, should be present for the
diagnosis of bronchiectasis.
Bronchial wall thickening is optimally seen with a WW of 1000 HU and a WL of 700
HU; higher WL and other WW readings are associated with artifactual wall
thickening.[20] This finding is not specific and is also seen in patients with asthma and in
those who smoke.
False positives/negatives
The variability of the bronchus-to-artery ratio at high altitudes and in patients with pulmonary
hypertension may result in an overdiagnosis because of vasoconstriction in these conditions. The
bronchial diameter relative to the adjacent pulmonary artery also increases with increasing
altitude.[88]
In patients with consolidation, dilated bronchi may not be seen. Cardiac and respiratory artifacts
may obscure the results or mimic subtle bronchiectasis in the left lower lobe. Rarely, histiocytosis X
and cavitating pulmonary masses mimic cystic bronchiectasis. Traction bronchiectasis occurs in
patients with interstitial fibrosis and results from fibrous tethering of the bronchial wall. Traction
bronchiectasis is not a true bronchial disorder.
The patients age should be considered, since the bronchoarterial ratio increases with age.[89] In rare
instances in adults, but more frequently in pediatric patients, bronchiectasis can be reversible.
A dilated, cystic bronchus should be distinguished from a bulla, since a bronchial cyst has a
perceptible wall, while a bulla does not.
At times, severely dilated bronchi with associated volume loss can simulate honeycombing
Magnetic Resonance Imaging
Hemoptysis is symptomatic of a potentially life-threatening condition and warrants urgent and comprehensive evaluation of the
lung parenchyma, airways, and thoracic vasculature.
Multidetector-row CT angiography permits noninvasive, rapid, and accurate assessment of the cause and consequences of
hemorrhage into the airways and helps guide subsequent management.[75, 97] The combined use of thin-section axial scans and
more complex reformatted images allows clear depiction of the origins and trajectories of abnormally dilated systemic arteries
that may be the source of hemorrhage and that may require embolization.
The vasculature, pulmonary parenchyma, and airways can be assessed with Multidetector CT angiography. In disorders with
chronic lung inflammation, including bronchiectasis, abnormal collateral systemic vessels form in the affected parts of the lung.
These collateral bronchial arteries appear as tortuous vessels and can bleed. Occasionally, nonbronchial systemic arteries or
pulmonary arteries bleed. Multiplanar reformatted images are used for identifying the origins and courses of these vessels.
Bronchiectasis, chronic bronchitis, lung malignancy, tuberculosis, and chronic fungal infection are some of the most common
underlying causes of hemoptysis and are easily detected with CT angiography.
Results from multidetector CT angiography can be used to direct therapeutic angiography for bronchial or pulmonary arterial
embolization or surgical resection.
Degree of confidence
Occasionally, an examination is limited by artifact from patient motion, data depletion from a very large patient, or timing of
contrast bolus. Otherwise, multidetector row CT usually demonstrates the vasculature and the pulmonary parenchyma well.
False positives/negatives
No large series using current CT techniques has been published for hemoptysis assessment. In a series of 22 patients, using 16-
detector row CT, bronchial (100%) and nonbronchial (62%) arteries causing hemoptysis were visible, with most traceable
throughout their length.[98] Substantial technological advances in CT since then allow more detailed visualization.
Bronhoscopie
Bronhoscopia (edem al
mucoasei, hipersecretie).
Bronhoscopia nu este, n general,
utila n diagnosticarea
bronsiectaziilor, dar poate fi util n
identificarea anomaliilor care stau la
baza aparitiei lor, cum ar fi tumorile,
corpuri strine, sau alte leziuni.
Bronhoscopia cu lavaj bronhoalveolar
pot fi utilizata pentru recoltare si
cultura si a determina
microorganismele ce colonizeaza
tractul respirator.Bronhoscopia cu
biopsie si examen histologic au o
informativitate inalta.
Diagnostic Diferential
Obiectivele tratamentului
Reducerea simptomelor
Reducerea complicatiilor
Controlul exacerbarilor
Reducerea morbiditatii si mortalitatii
Supportive Treatment
The following general measures are recommended:
Smoking cessation
Avoidance of second-hand smoke
Adequate nutritional intake with supplementation, if necessary
Immunizations for influenza and pneumococcal pneumonia [87, 88]
Confirmation of immunizations for measles, rubeola, and pertussis
Oxygen therapy is reserved for patients who are hypoxemic with
severe disease and end-stage complications, such as cor pulmonale.
Patients with cystic fibrosis (CF) should be cared for at specialized
CF treatment centers that address all aspects of the disease,
including nutritional and psychologic aspects.
Antibiotic Therapy
Antibiotics have been the mainstay of treatment for more than 40 years. Oral, parenteral, and aerosolized antibiotics are used, depending on the clinical situation.
In acute exacerbations, broad-spectrum antibacterial agents are generally preferred. However, if time and the clinical situation allows, sampling of respiratory secretions during an acute exacerbation may allow
treatment with antibiotics based on specific species identification.
Acceptable choices for the outpatient who is mild to moderately ill include any of the following:
Amoxicillin
Tetracycline
Trimethoprim-sulfamethoxazole
A newer macrolide (eg, azithromycin [6] or clarithromycin [7, 8] )
A second-generation cephalosporin
A fluoroquinolone
In general, the duration of antibiotic therapy for mild to moderate illness is 7-10 days.
For patients with moderate-to-severe symptoms, parenteral antibiotics, such as an aminoglycoside (gentamicin, tobramycin) and an antipseudomonal synthetic penicillin, a third-generation cephalosporin, or a
fluoroquinolone, may be indicated. Patients with bronchiectasis from CF are often infected with mucoid Pseudomonasspecies, and, as such, tobramycin is often the drug of choice for acute exacerbation.
Infection with Mycobacterium avium complex (MAC) provides special treatment challenges. For the treatment of MAC in the setting of bronchiectasis, the American Thoracic Society recommends a 3- to 4-drug
treatment regimen with clarithromycin, rifampin, ethambutol, and possibly streptomycin that is continued until the patient's culture results are negative for 1 year. The typical duration of therapy may be 18-24 months.
Regular antibiotic regimens
Some patients with chronic bronchial infections may need regular antibiotic treatment to control the infectious process. Some clinicians prefer to prescribe antibiotics on a regular basis or for a set number of weeks
each month.
The oral antibiotics of choice are the same as those mentioned previously. Potential regimens include daily antibiotics for 7-14 days of each month, alternating antibiotics for 7-10 days with antibiotic-free periods of 7-10
days, or a long-term daily dose of antibiotics. For patients with severe CF and bronchiectasis, intermittent courses of intravenous antibiotics are sometimes used. [89, 90]
Aerosolized antibiotics
In the past several years, the nebulized route of antibiotic administration has received more attention because it is capable of delivering relatively high concentrations of drugs locally with relatively few systemic
adverse effects.[91] This is particularly beneficial in treating patients with chronic infection from P aeruginosa. Currently, inhaled tobramycin is the most widely used nebulized treatment for patients with bronchiectasis
from either CF or non-CF causes of bronchiectasis.[92, 93, 94, 95, 96] Gentamicin[97] and colistin[98] have also been used.
No significant studies have examined the long-term use of inhaled antibiotics in patients with non-CF bronchiectasis. A study by Govan et al found sustained long-term benefit (12 mo) of inhaled gentamicin in this
subgroup, along with an acceptable side effect profile. [99] Optimal dosing regimen of inhaled gentamicin still needs to be elucidated.
Bronchial Hygiene
Good bronchial hygiene is paramount in the treatment of bronchiectasis, because of the tenacious sputum and
defects in clearance of mucus in these patients. Postural drainage with percussion and vibration is used to loosen and
mobilize secretions.
Devices available to assist with mucus clearance include flutter devices,[100, 101]intrapulmonic percussive ventilation
devices, and incentive spirometry.[102] Although consistent benefits from these techniques are lacking and vary with
patient motivation and knowledge, a review did report improvement in patients cough-related quality of life
scores.[103]
A relatively new device called the "Vest" system is a pneumatic compression device/vest that is worn by the patient
periodically throughout the day. It is essentially technique independent and has variable success, especially in patients
with CF. Significant controlled trials have not been performed in patients with non-CF bronchiectasis.
Nebulization with concentrated (7%) sodium chloride solutions appears to be beneficial, particularly in patients with
CF-related bronchiectasis.[104, 105, 106]Mucolytics, such as acetylcysteine, are also often tried but do not appear to be
universally beneficial. However, maintaining adequate general hydration, which may improve the viscidity of
secretions, is important.
Aerosolized recombinant DNase has been shown to benefit patients with CF.[107, 108] This enzyme breaks down DNA
released by neutrophils, which accumulates in the airways in response to chronic bacterial infection. However,
improvement has not been definitively shown in patients with bronchiectasis from other causes.[109]
Bronchodilator Therapy
Bronchodilators, including beta-agonists and anticholinergics, may help some patients with bronchiectasis,
presumably reversing bronchospasm associated with airway hyperreactivity and improving mucociliary clearance.[110,
111, 112] High-quality, large, randomized clinical trials of bronchodilator treatment in bronchiectasis have not been
performed, however.
Anti-inflammatory Therapy
The rationale of anti-inflammatory therapy is to modify the inflammatory response caused by the microorganisms associated with bronchiectasis and
subsequently reduce the amount of tissue damage. Inhaled corticosteroids,[113] oral corticosteroids,[114] leukotriene inhibitors,[115] and nonsteroidal anti-
inflammatory agents[115] have all been examined.
Although evidence suggests some benefit from the use of these agents, findings are not universally definitive. One study reported that inhaled corticosteroids
are beneficial compared with placebo in patients with bronchiectasis, particularly those with associated P aeruginosa infections.[116]
A double-blind, placebo controlled 6-week crossover study with 20 patients using beclomethasone dipropionate (750 mcg bid) showed reduced mean sputum
volume and improved forced expiratory volume in 1 second (FEV1) at 6 weeks. A similar study of 24 patients using fluticasone propionate (500 mcg bid) showed
reduced sputum leukocyte density and reduced levels of inflammatory mediators but no change in pulmonary function.
A study by Tsang et al showed benefit of inhaled fluticasone in patients with chronic P aeruginosa infection and bronchiectasis.[116] Another study showed
improvement in quality-of-life scores with inhaled steroids in patients with steady-state bronchiectasis.[117]
Azithromycin has known anti-inflammatory properties and long-term use has been studied in patients with both CF and non-CF bronchiectasis. In non-CF patients,
azithromycin has been shown to decrease exacerbations and improve spirometry and microbiologic profiles.[118, 119] In CF patients a meta-analysis suggests that it
improves lung function, especially in those patients colonized with Pseudomonas.[106]
A practical approach is to use tapering oral corticosteroids and antibiotics for acute exacerbations and to consider inhaled corticosteroids for daily use in patients
with significant obstructive physiology on pulmonary function testing and evidence of reversibility suggesting airway hyperreactivity. However, Kapur et al
reported that the evidence supporting the use of inhaled steroids in adults with stable bronchiectasis is insufficient.[120]
Adjunctive Surgical Resection
Surgery is an important adjunct to therapy in some patients with advanced or complicated disease. [121] Surgical resection for bronchiectasis can be performed with
acceptable morbidity and mortality in patients of any age.[94, 122, 123]
In general, surgery should be reserved for patients who have focal disease that is poorly controlled by antibiotics. The involved bronchiectatic sites should be
completely resected for optimal symptom control. Other indications for surgical intervention may include the following:
Reduction of acute infective episodes
Reduction of excessive sputum production
Massive hemoptysis (Alternatively, bronchial artery embolization may be attempted for the control of hemoptysis.)
Foreign body or tumor removal
Consideration in the treatment of MAC or Aspergillus species infections
Complications of surgical intervention include empyema, hemorrhage, prolonged air leak, and persistent atelectasis.
Patient selection plays an important role in perioperative mortality rates, which may be as low as 1% in the surgical treatment of segmental or even
multisegmental bronchiectasis.
Lung Transplantation
Single- or double-lung transplantation has been used as treatment of severe bronchiectasis, predominantly when
related to CF. In general, consider patients with CF and bronchiectasis for lung transplantation when FEV1 falls below
30% of the predicted value. Female patients and younger patients may need to be considered sooner.
Consultations
A pulmonologist or other practitioner skilled in caring for patients with bronchiectasis should be consulted. All
patients with CF should be referred to a regional center with the resources and trained personnel to care for patients
with CF, including nutritional and psychological care.
Long-Term Monitoring
The interval of follow-up care is determined by the patient's clinical condition and associated conditions or causes.
Patients with CF should optimally be monitored at a center specialized in the care of CF.
Medication Summary
No specific medical therapy exists for the treatment of bronchiectasis. Pharmacologic therapy focuses on the
treatment of infectious exacerbations that these patients commonly experience, most often in the form of an acute
bronchitis-type syndrome.
The most widely accepted and commonly used medications in the treatment of acute infectious processes associated
with bronchiectasis include antibiotics, beta-agonists, inhaled corticosteroids, and expectorants. Other more
controversial medications have been previously mentioned in this article for completeness but are not discussed here.
Antibiotics
Class Summary
These are the mainstays of treatment of patients with bronchiectasis and infectious exacerbations. The route of antibiotic administration varies with the overall clinical condition, with most patients doing well on
outpatient regimens. Some patients benefit from a set regimen of antibiotic therapy, such as therapy for 1 week of every month.
The choice of antibiotic is provider dependent, but, in general, the antibiotic chosen should have a reasonable spectrum of coverage, including the most common gram-positive and gram-negative organisms.
Treatment of the patient who is more ill or the patient with CF often requires intravenous anti-Pseudomonas species coverage with an aminoglycoside, most often in combination with an antipseudomonal synthetic
penicillin or cephalosporin. Aerosolized tobramycin has been found effective in patients with cystic fibrosis (CF).
View full drug information
Clarithromycin (Biaxin)
Clarithromycin is a semisynthetic macrolide antibiotic that reversibly binds to P site of 50S ribosomal subunit of susceptible organisms and may inhibit RNA-dependent protein synthesis by stimulating dissociation of
peptidyl t-RNA from ribosomes, causing bacterial growth inhibition.
View full drug information
Azithromycin (Zithromax, Zmax)
Azithromycin is an azalide, a subclass of the macrolide antibiotics. Following oral administration, it is absorbed rapidly and widely distributed throughout body. Its mechanism of action is interference with microbial
protein synthesis.
Azithromycin is effective against a wide range of organisms, including the most common gram-positive and gram-negative organisms. It has additional coverage of so-called atypical infections, such as Chlamydia,
Mycoplasma, and Legionella species. This agent is indicated for treatment of patients with mild-to-moderate infections, including acute bronchitic infections that may be observed with bronchiectasis.
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Trimethoprim and sulfamethoxazole (Septra DS, Bactrim DS)
Trimethoprim-sulfamethoxazole is a synthetic combination antibiotic. Each tab contains 80 mg of trimethoprim and 400 mg of sulfamethoxazole. It is rapidly absorbed after oral administration. The mechanism of
action involves blockage of 2 consecutive steps in biosynthesis of nucleic acids and proteins needed by many microorganisms.
This agent provides coverage for common forms of both gram-positive and gram-negative organisms, including susceptible strains of Streptococcus pneumoniae and Haemophilus influenzae. It is indicated in the
treatment of acute and chronic bronchitic symptoms in patients with bronchiectasis.
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Doxycycline (Doryx, Oraxyl, Vibramycin)
Doxycycline is a broad-spectrum, synthetically derived bacteriostatic antibiotic in the tetracycline class. It is an alternative agent for patients who cannot be given macrolides or penicillins.
Doxycycline is almost completely absorbed, concentrates in bile, and is excreted in urine and feces as a biologically active metabolite in high concentrations. It inhibits protein synthesis and, thus, bacterial growth by
binding to 30S and possibly 50S ribosomal subunits of susceptible bacteria. It may block dissociation of peptidyl tRNA from ribosomes, causing RNA-dependent protein synthesis to arrest.
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Levofloxacin (Levaquin)
Fluoroquinolones should be used empirically in patients likely to develop exacerbation due to resistant organisms to other antibiotics. Levofloxacin is rapidly becoming a popular choice in pneumonia. It is the L
stereoisomer of the D/L parent compound ofloxacin, the D form being inactive.
This agent is good for monotherapy, with extended coverage against Pseudomonas species and excellent activity against pneumococcus. It acts by inhibition of DNA gyrase activity. Bioavailability of the oral form
reportedly is 99%.
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Tobramycin (TOBI)
Tobramycin is an aminoglycoside specifically developed for administration with a nebulizer system. When inhaled, it is concentrated in airways, where it exerts an antibacterial effect by disrupting protein synthesis.
Tobramycin is active against a wide range of gram-negative organisms, including P aeruginosa. It is indicated for treatment of patients with CF and P aeruginosa infection.
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Gentamicin
A water-soluble injectable antibiotic of aminoglycoside group, gentamicin acts by inhibiting normal protein synthesis; it is active against variety of pathogenic organisms, including P aeruginosa. For treatment of
Pseudomonas species, it is often used in combination with an antipseudomonal synthetic penicillin or cephalosporin.
In patients with bronchiectasis, gentamicin (or other aminoglycosides) may be indicated in setting of severe respiratory tract infection or CF. Dosing regimens are numerous; adjust dose based on creatinine clearance
(CrCl) and changes in volume of distribution. Gentamicin may be administered IV or IM.
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Amikacin
Amikacin irreversibly binds to the 30S subunit of bacterial ribosomes; it blocks the recognition step in protein synthesis and causes growth inhibition. It is indicated for gram-negative bacterial coverage of infections
resistant to gentamicin and tobramycin. Amikacin is effective against P aeruginosa. Use patient's ideal body weight (IBW) for dosage calculation. The same principles of drug monitoring for gentamicin apply to
Inhaled Beta Agonist
Class Summary
Although no long-term studies have been performed with inhaled beta-agonists, these medications are routinely used in patients with bronchiectasis for multiple reasons. Bronchiectasis may cause an obstructive
defect on pulmonary function testing that may respond to inhaled beta-agonists. Many older patients with bronchiectasis often have a concomitant illness, such as chronic obstructive pulmonary disease, that responds
to inhaled beta-agonists.
Finally, in the acute infectious bronchitic exacerbation that occurs in patients with bronchiectasis, patients may develop transient obstructive airway physiology that may improve with an inhaled beta-agonist. Along
these same lines, many patients are started on inhaled steroids for long-term airway stabilization, but the efficacy of these medications in bronchiectasis is questionable, and any effect simply may be secondary to the
treatment of other concomitant obstructive airway diseases.
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Salmeterol (Serevent Diskus)
By relaxing the smooth muscles of the bronchioles in conditions associated with bronchitis, emphysema, asthma, or bronchiectasis, salmeterol can relieve bronchospasms. It also may facilitate expectoration.
Salmeterol has been shown to improve symptoms and morning peak flows. It may be useful when bronchodilators are used frequently. More studies are needed to establish the role for these agents.
The bronchodilating effect of salmeterol lasts >12 h. This agent is used on a fixed schedule in addition to regular use of anticholinergic agents. When salmeterol is administered at high or more frequent doses than
recommended, the incidence of adverse effects is higher.
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Albuterol sulfate (Proventil, Ventolin)
Albuterol is a relatively selective beta2-adrenergic bronchodilator that, when inhaled, relaxes bronchial smooth muscle and inhibits release of mediators of immediate hypersensitivity from cells, especially mast cells.
Albuterol is administered in a metered-dose aerosol unit for oral inhalation. It is indicated for prevention and relief of bronchospasm from any cause, including those observed in patients with bronchiectasis.
Inhaled Corticosteroids
Class Summary
Studies suggest a benefit of inhaled corticosteroids in bronchiectasis, although the optimal dosing remains to be determined. No significant studies of oral steroid therapy in patients with bronchiectasis have been
performed.
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Beclomethasone (Qvar)
Beclomethasone inhibits bronchoconstriction mechanisms, produces direct smooth muscle relaxation, and may decrease the number and activity of inflammatory cells, in turn decreasing airway hyperresponsiveness.
It is readily absorbed through the nasopharyngeal mucosa and GI tract. It has a weak hypothalamic-pituitary-adrenal (HPA) axis inhibitory potency when applied topically.
Various dose preparations are available and must be titrated in conjunction with other medications the patient is taking; most inhaled oral medications have an effect in 24 hours.
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Fluticasone inhaled (Flovent Diskus)
Fluticasone may decrease the number and activity of inflammatory cells, in turn decreasing airway hyperresponsiveness. It also has vasoconstrictive activity.
Expectorants
Class Summary
One of the hallmarks of bronchiectasis is a chronic, thick, viscid sputum production. In
bronchiectasis, it is extremely difficult for the body's natural mucociliary clearance mechanisms to
adequately clear the sputum produced. Although definitive evidence is lacking, expectorants are
expected to increase respiratory tract fluid secretions and to help loosen phlegm and bronchial
secretions.
By reducing the viscosity of secretions, expectorants increase the efficacy of the mucociliary
clearance system. Expectorants are often marketed in combination with decongestants, which may
provide some patients additional relief.
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Guaifenesin (Mucinex)
The product contains 600 mg of guaifenesin in a sustained-release formulation intended for oral
administration. It increases respiratory tract fluid secretions and helps to loosen phlegm and
bronchial secretions. Humibid LA and guaifenesin are indicated for patients with bronchiectasis
complicated by tenacious mucus and/or mucous plugs.
Complicatii
Prognostic