Clasa Proteina Rol In Faza acuta Cresteri scadere

TBPA (thyroid binding Transp hh. tiroidieni Hemoconcentratie Deficit de aport, absorbtie, sinteza, insuficienta
na
Prealbumi
prealbumin) - hepatica, pierdere (sd. nefrotic) sau hemodilutie
scade

Alfa 1 antitripsina E antiproteaza  inhiba alte proteaze

Α1
Alfa 1 glicoproteina acida Transporta colesterol, aparare nespecifica
In inflamatii
Haptoglobina Leaga Hb libera Aceleasi situatii + deficit genetic si consum
crescut in hemoliza vasculara
+ creste
Ceruloplasmina Transporta cupru (Cu e excretat prin bila) Inflamatii + colestaza pt ca se Aceleasi + boala Wilson (degenerescenta hepato-
A2
aduna Cupru lenticulara cu Inel Kayser Fleischer)
Alfa 2 macroglobulina Anti-proteaza, imunitate Inflamatii + sd nefrotic (nu se Insuficienta hepatica
pierde)
Beta 2 microglobulina Sintetizata de limfocite (formeaza In afectiuni cu proliferare In SIDA, neoplazii
receptor de pe LB) limfocitara (boli imune)
B2
Transferina Duce Fe la tesuturi Creste cand e putin Fe (anemie Inflamatii, deficit de sinteza hepatica
feripriva)
Fibrinogen Fact 1 al coagularii Inflamatii si in pierderea renala Deficit de aport, absorbtie, sinteza, insuficienta
de albumina hepatica, pierdere (sd. nefrotic) sau hemodilutie
Prot C reactiva Opsonizare, clearance detritusuri celulare, + Creste Inflamatii, infectii, In tratament cu AINS
activare complement autoimunitate, arsuri,
interventii chirurgicale
Ig A Imunitate mucoase; in secretii digestive, Lezari mucoase, alcoolism Congenital; scadere populatie de limfocite
Gama
lacrimi, saliva, lapte matern
Ig M Inflamatie acuta  primii Ac
Inf acute, status proinflamator La nou nascut; congenital
IgD Activare LB, mastocite, bazofile
Ig E Reactie alergica tip 1; activare mastocite, Boli atopice (astm alergic, congenital
bazofile eczeme)
Ig G Inflamatie cronica; trece prin placenta Infectii acute/ cronice Deficit congenital, Sd nefrotic
Alfa 1 fetoproteina La gravide sau marker de multiplicare In neoplazii & malformatii Sarcina molara
celulara la neoplazie fetale de tub neural
anormal

Antigen carcinoembrionar Se produce in perioada embrionara in CRESTE IN Neoplasm colorectal, mamar, gastric, ovarian
CEA pancreas, ficat, intestin Pancreatita, ciroza, hepatita, colita ulcerativa, Crohn, polipi, diverticuli
CA 15-3 Cancer mamar
CA 19-9 ADK pancreatic, gastric, neo colorectal, ovarian
CA 125 Neo ovarian, ADK pancreatic

VSH – crescut: infectii, inflamatii, neo, autoimunitate, afectiuni hematologice cu crestere de Ig

- Scazut: cand e fibrinogen putin; in policitemie
Intr-o inflamatie cronica va creste fractia gamma; in acuta: in special alfa 1 + 2
In Sd nefrotic: scade albumina; cresc alfa2 si beta pt ca nu se pierd
In hepatita: beta si gama cresc; albumina scade in functie de severitate - la fel si in ciroza