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CAROL DAVILA
BUCURESTI
CURS
DE
NEUROLOGIE
SISTEMUL EXTRAPIRAMIDAL
SISTEMUL STRIAT
ESTE LEGAT DE STRUCTURI:
SISTEMUL STRIAT
FUNCŢIONEAZĂ PRIN
CONEXIUNILE DINTRE ACESTE STRUCTURI
Conf. Dr. Ioan Buraga - Curs Neurol
ogie
Cortico-basal ganglionic-thalamocortical loop
The striatum (CN = caudate, PUT = putamen) receives excitatory, glutamatergic (GLU = glutamate) from cortical
pyramidal neurons. In turn, the striatum gives rise to GABAergic projections to the pallidum and substantia nigra.
The medial globus pallidus and substantia nigra par reticulata originate GABAergic projections to the ventral
anterior and ventral lateral thalamus as well as the dorsomedial thalamus. In turn, these thalamic nuclei send
projections, excitatory and probably glutamatergic, to cortex. Within this general loop are two additional sub-loops.
The striatum is reciprocally connected with the substantia nigra pars compacta, the latter providing the massive
dopaminergic innervation of the striatum. The second sub-loop is the projection from striatum to lateral globus
pallidus, which projects in turn to the subthalamic nucleus, the latter producing excitatory, glutamatergic projections
to the medial segment of the globus pallidus and pars reticula of the substantia nigra.
AFERENŢE
NEOCORTEX (virtual de la toate ariile
neocorticale) - cea mai mare
TALAMUS (nucleul centromedian)
SUBSTANŢA NEAGRĂ.
SUBSTANŢA NEAGRĂ
EFERENŢE (PARS RETICULARA)
DOI NUCLEI MAJORI:
GLOBUS PALLIDUS
NUCLEUL SUBTALAMIC
AFERENŢE EFERENŢE
GLOBUS PALLIDUS
CORTEXUL MOTOR GLOBUS PALLIDUS
EFERENŢE:
• CORTEXUL MOTOR ARIA 4 - DE LA NUCLEII VENTRO-LATERAL ŞI
CENTRO-MEDIAN
• CORTEXUL PREMOTOR ARIA 6 - DE LA NUCLEII VENTRAL-ANTERIOR
ŞI VENTRAL-LATERAL
• ARIA MOTORIE SUPLIMENTARĂ - DE LA NUCLEII VENTRAL-LATERAL
ŞI VENTRAL-ANTERIOR
Conf. Dr. Ioan Buraga - Curs Neurol
ogie
Conf. Dr. Ioan Buraga - Curs Neurol
ogie
Conf. Dr. Ioan Buraga - Curs Neurol
ogie
Conf. Dr. Ioan Buraga - Curs Neurol
ogie
Conf. Dr. Ioan Buraga - Curs Neurol
ogie
Conf. Dr. Ioan Buraga - Curs Neurol
ogie
Conf. Dr. Ioan Buraga - Curs Neurol
ogie
Conf. Dr. Ioan Buraga - Curs Neurol
ogie
Conf. Dr. Ioan Buraga - Curs Neurol
ogie
Conf. Dr. Ioan Buraga - Curs Neurol
ogie
Conf. Dr. Ioan Buraga - Curs Neurol
ogie
Conf. Dr. Ioan Buraga - Curs Neurol
ogie
Conf. Dr. Ioan Buraga - Curs Neurol
ogie
Conf. Dr. Ioan Buraga - Curs Neurol
ogie
Conf. Dr. Ioan Buraga - Curs Neurol
ogie
Conf. Dr. Ioan Buraga - Curs Neurol
ogie
Conf. Dr. Ioan Buraga - Curs Neurol
ogie
Conf. Dr. Ioan Buraga - Curs Neurol
ogie
Conf. Dr. Ioan Buraga - Curs Neurol
ogie
Conf. Dr. Ioan Buraga - Curs Neurol
ogie
Conf. Dr. Ioan Buraga - Curs Neurol
ogie
Conf. Dr. Ioan Buraga - Curs Neurol
ogie
Conf. Dr. Ioan Buraga - Curs Neurol
ogie
Conf. Dr. Ioan Buraga - Curs Neurol
ogie
Conf. Dr. Ioan Buraga - Curs Neurol
ogie
Conf. Dr. Ioan Buraga - Curs Neurol
ogie
Conf. Dr. Ioan Buraga - Curs Neurol
ogie
Conf. Dr. Ioan Buraga - Curs Neurol
ogie
Conf. Dr. Ioan Buraga - Curs Neurol
ogie
Conf. Dr. Ioan Buraga - Curs Neurol
ogie
Conf. Dr. Ioan Buraga - Curs Neurol
ogie