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Boala Parkinson
Boala Parkinson
Bolnavi notabili
Salvador Dali
Muhammad Ali
Bolnavi notabili
Mao Zedong
Ray Kennedy
ETIOPATOLOGIE
• Boală neurodegenerativă
– Degenerescența sistemelor:
DOPAMINergice centrale
alte căi monoaminergice (NA, Serotonina)
Subs. P alterată
GABA alterată
Metenkefalină alterată
1. Paliativ
2. Invaziv
3. Trial
1. Paliativ
Preparate Anti-Parkinsoniene:
• Prep. ce activează sistemul dopaminergic
– Dopaminomimetice (agoniști ai receptorilor
dopaminergici)
– Inhibitori ai MAO-b
• Preparate ce inhibă influențele glutamatergice
• Preparate ce inhibă influențele colinergice
(Anticolinergice )
NMDA-Receptorii
TRATAMENTUL
1. Paliativ
2. Invaziv
3. Trial
TRATAMENTUL
1. Paliativ
2. Invaziv
3. Trial
Implantable Electrodes for the
Treatment of Parkinson's Disease
Deep brain stimulation (DBS) is
approved in the United States by the
Food and Drug Administration for the
treatment of Parkinson's.[*] DBS carries
the risks of major surgery, with a
complication rate related to the
experience of the surgical team.
* Krauss JK, Jankovic J. Surgical Treatment of Parkinson's Disease. American Family Physician 1996; 54:1624.
Bibliografie
• Farmacologie, D.A.Harchevici, Chișinău 2009
• Textbook Of Medical Physiology (Guyton 11th ed)
• Lippincott's Pharmacology, ed.2009
• Rang and Dales Pharmacology 6th Ed, 2007
• Neurosurgical Treatment of Movement Disorders, Isabelle M.
Germano